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Radiochimica Acta

International Journal for chemical aspects of nuclear science and technology

Editor-in-Chief: Qaim, Syed M.

12 Issues per year


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2193-3405
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Volume 99, Issue 10

Issues

Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals

S. Huclier-Markai / A. Sabatie / S. Ribet / V. Kubícek
  • 3 Charles University in Prague, Department of Inorganic Chemistry, Prague, Tschechische Republik
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ M. Paris / C. Vidaud / P. Hermann
  • 6 Charles University in Prague, Department of Inorganic Chemistry, Prague, Tschechische Republik
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ C. S. Cutler
Published Online: 2011-08-04 | DOI: https://doi.org/10.1524/ract.2011.1869

Abstract

Scandium isotopes (44Sc, 47Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental data on stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III) with the ligands were determined by free-ion selective radiotracer extraction, complemented by 45Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA < NOTA < EDTA < DTPA < DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.

Keywords: Scandium complexes; Polyaminopolycarboxylate ligands; Stability; Positron emission tomography

About the article

* Correspondence address: Université de Nantes, Ecole des Mines de Nantes/CNRS/IN2P3, 4 rue A. Kastler, PB 20722, Laboratoire Subatech, 44307 Nantes Cedex 3, Frankreich,


Published Online: 2011-08-04

Published in Print: 2011-10-01


Citation Information: Radiochimica Acta International journal for chemical aspects of nuclear science and technology, Volume 99, Issue 10, Pages 653–662, ISSN (Print) 0033-8230, DOI: https://doi.org/10.1524/ract.2011.1869.

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© by Oldenbourg Wissenschaftsverlag, Nantes Cedex 3, Germany. Copyright Clearance Center

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