Abstract
The halogens bromine and iodine have similar chemical properties and undergo similar reactions due to their closeness in Group 17 of the periodic chart. There are a number of bromine and iodine radionuclides that have properties useful for diagnosis and therapy of human diseases. The emission properties of radiobromine and radioiodine nuclides with half-lives longer than 1 h are summarized along with properties that make radionuclides useful in PET/SPECT imaging and β/Auger therapy, such that the reader can assess which of the radionuclides might be useful for medical applications. An overview of chemical approaches that have been used to radiolabel molecules with radiobromine and radioiodine nuclides is provided with examples. Further, references to a large variety of different organ/cancer-targeting agents utilizing the radiolabeling approaches described are provided.
Dedicated to: This review is dedicated to Dr. Thomas Ruth for his many contributions to radiohalogen chemistry, and his mentoring/friendship over our careers.
Funding source: Nuclear Physics
Award Identifier / Grant number: DE-SC0018013
Funding statement: Nuclear Physics, Funder Id: http://dx.doi.org/10.13039/100006209, Grant Number: DE-SC0018013.
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