Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Radiology and Oncology

The Journal of Association of Radiology and Oncology

4 Issues per year

IMPACT FACTOR 2016: 1.681
5-year IMPACT FACTOR: 1.723

CiteScore 2016: 1.70

SCImago Journal Rank (SJR) 2016: 0.538
Source Normalized Impact per Paper (SNIP) 2016: 0.921

Open Access
See all formats and pricing
More options …
Volume 44, Issue 4


Evaluation of clinical interventions made by pharmacists in chemotherapy preparation

Lea Knez
  • Academic Department of Pharmacy, Barts and The London NHS Trust, Royal London Hospital, London, UK
  • Pharmacy Department, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Raisa Laaksonen
  • Academic Department of Pharmacy, Barts and The London NHS Trust, Royal London Hospital, London, UK
  • Pharmacy Practice Group, Department of Pharmacy & Pharmacology, University of Bath, Bath, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Catherine Duggan
  • Academic Department of Pharmacy, Barts and The London NHS Trust, Royal London Hospital, London, UK
  • Clinical Pharmacy, Development and Evaluation for East & South East England Specialist Services, NHS, UK
  • The School of Pharmacy, London, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-09-22 | DOI: https://doi.org/10.2478/v10019-010-0040-x

Evaluation of clinical interventions made by pharmacists in chemotherapy preparation

Background. Cancer drugs are high risk drugs and medication errors in their prescribing, preparation and administration have serious consequences, including death. The importance of a multidisciplinary approach and the benefits of pharmacists' contribution to cancer treatment to minimise risk have been established. However, the impact of services provided by pharmacists to cancer patient care is poorly studied. This study explored the clinical interventions made by pharmacists in dispensing of chemotherapy doses, and evaluated pharmacists' contribution to patient care.

Methods. Pharmacists at the Chemotherapy Preparation Unit at a tertiary cancer centre in London were shadowed by two research pharmacists during the clinical screening of chemotherapy prescriptions and release of prepared drugs. An expert panel of pharmacy staff rated the clinical significance of the recorded interventions.

Results. Twenty-one pharmacists' interventions were recorded during the screening or releasing of 130 prescriptions or drugs. "Drug and therapy" (38%), "clerical" (22%) and "dose, frequency and duration" (19%) related problems most often required an intervention, identifying areas in chemotherapy prescribing that need improvement. The proposed recommendations were implemented in 86% of the cases. Many recorded interventions (48%) were ranked to have had a "very significant" influence on patient care.

Conclusion. Clinical interventions made by pharmacists had a significant impact on patient care. The integration of pharmacists' technical and clinical roles into dispensing of chemotherapy doses is required for providing high-quality cancer services.

Keywords: pharmacy; cancer; chemotherapy; drug compounding; medication errors

  • Phillips J, Beam S, Brinker A, Holquist C, Honig P, Lee LY, et al. Retrospective analysis of mortalities associated with medication errors. Am J Health Syst Pharm 2001; 58: 1835-41.Google Scholar

  • Ocvirk J, Boc M, Rebersek M, Ros T. Cisplatin-induced non-convulsive posterior reversible encephalopathy syndrome in a 41-year-old woman with metastatic malignant melanoma. Radiol Oncol 2009; 43: 120-5.Web of ScienceGoogle Scholar

  • Department of Health. The NHS cancer plan. London: HMSO; 2001.Google Scholar

  • Goldspiel BR, DeChristoforo R, Daniels CE. A continuous-improvement approach for reducing the number of chemotherapy-related medication errors. Am J Health Syst Pharm 2000; 57: S4-9.Google Scholar

  • Mort D, Lansdown M, Smith N, Protopapa K, Mason M. For better, for worse? London: National Confidential Enquiry into Patient Outcome and Death; 2008.Web of ScienceGoogle Scholar

  • North East London Cancer Network NHS. Guidelines on the safe prescribing, handling and administration of cytotoxic drugs. London: Department of Health Publications; 2005.Google Scholar

  • German Society of Oncology Pharmacy. Quality Standard for the Oncology Pharmacy Service with Commentary. 4th Edition. Oldenburg: Onko-press; 2003.Google Scholar

  • Adams V, Blake D, Corlett S, Godward D, Low J, McMurray A, et al. Competency Framework for Specialist Oncology Pharmacists. BOPA Newsletter, 2004.Google Scholar

  • Markert A, Thierry V, Kleber M, Behrens M, Engelhardt M. Chemotherapy safety and severe adverse events in cancer patients: strategies to efficiently avoid chemotherapy errors in in- and outpatient treatment. Int J Cancer 2009; 124: 722-8.Google Scholar

  • Jaehde U, Liekwig A, Simons S, Westfeld M. Minimising treatment-associated risks in systemic cancer therapy. Pharm World Sci 2008; 30: 161-8.Web of ScienceGoogle Scholar

  • Slama C, Jerome J, Jacquot C, Bonan B. Prescription errors with cytotoxic drugs and inadequacy of existing classifications. Pharm World Sci 2005; 27: 339-43.Google Scholar

  • Liekweg A, Westfeld M, Jaehde U. From oncology pharmacy to pharmaceutical care: new contributions to multidisciplinary cancer care. Support Care Cancer 2004; 12: 73-9.Google Scholar

  • Debevec L, Jerič T, Kovač V, Bitenc M, Sok M: Is there any progress in routine management of lung cancer patients? A comparative analysis of an institution in 1996 and 2006. Radiol Oncol 2009; 43: 47-53.Web of ScienceGoogle Scholar

  • Knez L, Laaksonen R, Duggan C, Nijjar R. Evaluation of clinical interventions made by pharmacists in cancer services. Pharm J 2008; 280: 277-80.Google Scholar

  • Burtonwood AM, Hinchliffe AL, Tinkler GG. A prescription for quality: a role for the clinical pharmacist in general practice. Pharm J 1998; 261: 678-80.Google Scholar

  • Eadon H. Assessing the quality of ward pharmacists' interventions. Int J Pharm Practice 1992; 1: 145-7.Google Scholar

  • Price RN, Rogers A. Intervention monitoring on admissions wards. Hosp Pharmacists 2000; 7: 81-4.Google Scholar

  • Barber N, Batty R, Ridout DA. Predicting the rate of physician-accepted interventions by hospital pharmacists in the United Kingdom. Am J Health Syst Pharm 1997; 54: 397-405.Google Scholar

  • Hawkey CJ, Hodgon S, Norman A, Daneshmend TK, Garner ST. Effect of reactive pharmacy intervention on quality of hospital prescribing. Br Med J 1990; 300: 986-990.Google Scholar

  • Allan EL, Barker KN. Fundamentals of medication error research. Am J Hosp Pharm 1990; 47: 555-71.Google Scholar

  • Bowling A. Research methods in health. Philadelphia: Open University Press; 2002.Google Scholar

  • Macintyre J, Dalrymple H, MacLean F, Lannigan N, Hudson S. Development of a system for reporting pharmaceutical care issues in cancer patients receiving chemotherapy. Pharm J 2003; 271: 266-7.Google Scholar

  • Limat S, Drouhin JP, Demesmay K, Tissot E, Jacquet M, Woronoff-Lemsi MC. Incidence and risk factors of preparation errors in centralized cytotoxic preparation unit. Pharm World Sci 2001; 23: 102-6.Google Scholar

  • Bourret JA, Demeres RF, Wordell D, Irani M, Baker J, Evangelista C. Medication use review process and information systems utilized for oncology chemotherapy quality improvement. Pharm Pract Manag Q 1996; 16: 1-17.PubMedGoogle Scholar

  • Barber N, Cornford T, Klecun E. Qualitative evaluation of an electronic prescribing and administration system. Qual Saf Health Care 2007; 16: 271-8.Web of ScienceGoogle Scholar

  • Nebeker JR, Hoffman JM, Weir CR, Bennett CL, Hurdle JF. High rates of adverse drug events in a highly computerized hospital. Arch Intern Med 2005; 165: 1111-6.Google Scholar

About the article

Published Online: 2010-09-22

Published in Print: 2010-12-01

Citation Information: Radiology and Oncology, Volume 44, Issue 4, Pages 249–256, ISSN (Online) 1581-3207, ISSN (Print) 1318-2099, DOI: https://doi.org/10.2478/v10019-010-0040-x.

Export Citation

This content is open access.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Himanshu Patel and Parthasarathi Gurumurthy
Journal of Oncology Pharmacy Practice, 2017, Page 107815521773968
Lene Kjeldsen, Trine Nielsen, and Charlotte Olesen
Pharmacy, 2017, Volume 5, Number 2, Page 31
Ji-Min Han, Young-Mi Ah, Sung Yun Suh, Sun-Hoi Jung, Hyeon Joo Hahn, Seock-Ah Im, and Ju-Yeun Lee
International Journal of Clinical Pharmacy, 2016, Volume 38, Number 5, Page 1124
Thi-Ha Vo, Bruno Charpiat, Claire Catoire, Michel Juste, Renaud Roubille, François-Xavier Rose, Sébastien Chanoine, Jean-Luc Bosson, Ornella Conort, Benoît Allenet, and Pierrick Bedouch
Drug Safety, 2016, Volume 39, Number 2, Page 131
Vanessa Hegele, Paula Stoll, Diego Wüst, Guilherme Ehrenbrink, Luiza Raquel Grazziotin, Juliana Prohonoski Caregnato, and Luciane Pereira Lindenmeyer
International Journal of Clinical Pharmacy, 2013, Volume 35, Number 4, Page 513
Ting Ting Yeoh, Phebe Si, and Lita Chew
Supportive Care in Cancer, 2013, Volume 21, Number 5, Page 1287

Comments (0)

Please log in or register to comment.
Log in