Reviews in Analytical Chemistry
Editor-in-Chief: Schechter, Israel
Editorial Board Member: Pauw, Edwin / Vries, Mattanjah / Grushka, Eli / Laserna, J. / Licht, Stuart / Lubman, David / Mandler, Daniel / Palleschi, Vincenzo / Sigman, Michael / Whitesides, George
4 Issues per year
IMPACT FACTOR 2016: 1.917
CiteScore 2016: 2.09
SCImago Journal Rank (SJR) 2016: 0.528
Source Normalized Impact per Paper (SNIP) 2016: 1.017
Analysis of clenbuterol residues in pig liver using liquid chromatography electrospray ionization tandem mass spectrometry
The liquid chromatography-electrospray ionization tandem mass spectrometry method was developed for determination of clenbuterol residues in liver tissue as a regulatory matrix for the control of clenbuterol abuse as an anabolic. To investigate the level of clenbuterol residues during the withdrawal period, male food-producing pigs were exposed to subchronic repeat oral administration of a clenbuterol growth-promoting dose for 28 days. The analytical procedure showed acceptable validation results for all liver spiked samples analyzed and proved to be useful as a quantification and confirmation method in supporting regulatory enforcement programs of clenbuterol misuse monitoring. The highest level of clenbuterol in the liver of treated animals was recorded on day 0 of treatment cessation (21.58±14.29 ng/g), followed by 6.59±3.11 ng/g on day 3, 0.83±0.27 ng/g on day 7, and 0.44±0.08 ng/g on day 14 of withdrawal. At the end of the study period (day 35), the concentration of clenbuterol was below the method limit of detection (<0.1 ng/g).
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.