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Reviews on Environmental Health

Editor-in-Chief: Carpenter, David O. / Sly, Peter

Editorial Board: Brugge, Doug / Edwards, John W. / Field, R.William / Garbisu, Carlos / Hales, Simon / Horowitz, Michal / Lawrence, Roderick / Maibach, H.I. / Shaw, Susan / Tao, Shu / Tchounwou, Paul B.


IMPACT FACTOR 2017: 1.284

CiteScore 2017: 1.29

SCImago Journal Rank (SJR) 2017: 0.438
Source Normalized Impact per Paper (SNIP) 2017: 0.603

Online
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2191-0308
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Volume 26, Issue 1

Issues

Baseline determination in social, health, and genetic areas in communities affected by glyphosate aerial spraying on the northeastern Ecuadorian border

César Paz-y-Miño
  • Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador
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/ María José Muñoz
  • Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador
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/ Adolfo Maldonado / Carolina Valladares / Nadia Cumbal
  • Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador
  • Carrera de Ingeniería en Biotecnología, Facultad de Ciencias de la Vida, Escuela Politécnica del Ejército, Sangolquí, Ecuador
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/ Catalina Herrera
  • Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador
  • Escuela de Química y Biología, Universidad Central del Ecuador, Quito, Ecuador
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/ Paulo Robles
  • Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador
  • Escuela de Química y Biología, Universidad Central del Ecuador, Quito, Ecuador
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/ María Eugenia Sánchez
  • Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador
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/ Andrés López-Cortés
  • Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador
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Published Online: 2011-03-16 | DOI: https://doi.org/10.1515/reveh.2011.007

Abstract

The northeastern Ecuadorian border has undergone aerial spraying with an herbicide mix that contains surfactants and adjuvants, executed by the Colombian Government. The purpose of this study was to diagnose social, health, and genetic aspects of the people affected by glyphosate. For this objective to be achieved, 144 people were interviewed, and 521 medical diagnoses and 182 peripheral blood samples were obtained. Genotyping of GSTP1 Ile105Val, GPX-1 Pro198Leu, and XRCC1 Arg399Gln polymorphisms were analyzed, using PCR-RFLP technique. The assessment of chromosomal aberrations was performed, obtaining 182 karyotypes. Malnutrition in children was 3%. Of the total population, 7.7% had children with malformations, and the percentage of abortions was 12.7%. Concerning genotyping, individuals with GSTP1 Val/Val obtained an odds ratio of 4.88 (p<0.001), and Ile/Val individuals, together with Val/Val individuals, had an odds ratio of 2.6 (p<0.05). In addition, GPX-1 Leu/Leu individuals presented an odds ratio (OR) of 8.5 (p<0.05). Regarding karyotyping, the 182 individuals had normal karyotypes. In conclusion, the study population did not present significant chromosomal and DNA alterations. The most important social impact was fear. We recommend future prospective studies to assess the communities.

Keywords: Arg399Gln; GPX-1; GSTP1; Ile105Val; Pro198Leu; XRCC1

About the article

Corresponding author: César Paz-y-Miño, MD DB, Universidad de las Américas, Av. de los Granados y Colimes 1er P, Quito 1712842, Ecuador Phone: +(593-2) 3340229


Published Online: 2011-03-16

Published in Print: 2011-03-01


Citation Information: Reviews on Environmental Health, Volume 26, Issue 1, Pages 45–51, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: https://doi.org/10.1515/reveh.2011.007.

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