Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Reviews on Environmental Health

Editor-in-Chief: Carpenter, David O. / Sly, Peter

Editorial Board Member: Brugge, Doug / Edwards, John W. / Field, R.William / Garbisu, Carlos / Hales, Simon / Horowitz, Michal / Lawrence, Roderick / Maibach, H.I. / Shaw, Susan / Tao, Shu / Tchounwou, Paul B.

4 Issues per year


CiteScore 2016: 1.95

SCImago Journal Rank (SJR) 2016: 0.543
Source Normalized Impact per Paper (SNIP) 2016: 0.885

Online
ISSN
2191-0308
See all formats and pricing
More options …
Volume 28, Issue 1 (Apr 2013)

Issues

Human exposures to bisphenol A: mismatches between data and assumptions

Laura N. Vandenberg
  • Corresponding author
  • Center for Regenerative and Developmental Biology, Tufts University, Suite 4600, 200 Boston Avenue, Medford, MA 02155, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Patricia A. Hunt
  • School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ John Peterson Myers / Frederick S. vom Saal
Published Online: 2013-04-04 | DOI: https://doi.org/10.1515/reveh-2012-0034

Abstract

Human exposure to bisphenol A (BPA), a synthetic estrogen found in numerous consumer products, is widespread. However, scientific knowledge about the sources and routes of exposure remains incomplete. Although human biomonitoring studies report small amounts of bioactive BPA in the blood of most subjects, toxicokinetic models suggest that circulating levels should be undetectable. The conflict between reported data and toxicokinetic models has spurred considerable debate, with some suggesting that data from analyses of human blood should be dismissed in their entirety. This review addresses the assumptions used by previous risk assessment panels regarding the sources and routes of exposure to BPA (specifically, that BPA exposures occur solely via a few dietary sources) and how these assumptions have affected the interpretation of BPA studies. Given new experimental evidence that route of exposure influences BPA pharmacokinetics, we consider the implications of basing regulatory decisions on limited data that have provided incomplete information about the products that contain this chemical and how it enters the body. We also address evidence that challenges the assumption that humans metabolize BPA rapidly enough to result in undetectable levels in blood and therefore determine that there is a possibility of harm from current exposure levels. Our conclusions are consistent with the large number of hazards and adverse effects identified in laboratory animals exposed to low doses of BPA.

Keywords: contamination; endocrine disruptor; metabolism; urine; xenoestrogen

About the article

Corresponding author: Laura N. Vandenberg, Center for Regenerative and Developmental Biology, Tufts University, Suite 4600, 200 Boston Avenue, Medford, MA 02155, USA, Phone: +1-617-627-4094, Fax: +1-617-627-5035


Received: 2012-12-13

Accepted: 2013-03-06

Published Online: 2013-04-04

Published in Print: 2013-04-01


Citation Information: Reviews on Environmental Health, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: https://doi.org/10.1515/reveh-2012-0034.

Export Citation

©2013 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Luísa Correia-Sá, Sónia Norberto, Cristina Delerue-Matos, Conceição Calhau, and Valentina F. Domingues
Journal of Chromatography B, 2017
[2]
Luísa Correia-Sá, Monika Kasper-Sonnenberg, André Schütze, Claudia Pälmke, Sónia Norberto, Conceição Calhau, Valentina F. Domingues, and Holger M. Koch
Environmental Science and Pollution Research, 2017
[3]
Erin Speiser Ihde, Stacy Zamudio, Ji Meng Loh, Yalin Zhu, John Woytanowski, Lawrence Rosen, Min Liu, and Brian Buckley
Human and Ecological Risk Assessment: An International Journal, 2017, Page 0
[4]
Youn-Hee Lim, Sanghyuk Bae, Bung-Nyun Kim, Choong Ho Shin, Young Ah Lee, Johanna Inhyang Kim, and Yun-Chul Hong
Environmental Health, 2017, Volume 16, Number 1
[5]
Kaliappan Krishnapriya, Ganesan Shobana, Subramaniam Narmadha, Mathan Ramesh, and Vettaegounder Maruthappan
Ecohydrology & Hydrobiology, 2017
[6]
Ri-ping Huang, Ze-hua Liu, Su-fen Yuan, Hua Yin, Zhi Dang, and Ping-xiao Wu
Environmental Pollution, 2017, Volume 230, Page 143
[7]
Meghan R. Bernier, Laura N. Vandenberg, and Angel Nadal
PLOS ONE, 2017, Volume 12, Number 6, Page e0178449
[8]
Corinne E. Hill, Sarah A. Sapouckey, Alexander Suvorov, Laura N. Vandenberg, and Udo Schumacher
Cogent Medicine, 2017, Volume 4, Number 1
[9]
Paola Palanza and Stefano Parmigiani
Neuroscience & Biobehavioral Reviews, 2017, Volume 76, Page 134
[10]
Sazan Ali, Gérard Steinmetz, Guillaume Montillet, Marie-Hélène Perrard, Anderson Loundou, Philippe Durand, Marie-Roberte Guichaoua, Odette Prat, and Xuejiang Guo
PLoS ONE, 2014, Volume 9, Number 9, Page e106245
[11]
Susanne Petzold, Marco Averbeck, Jan C. Simon, Irina Lehmann, Tobias Polte, and Christopher Torrens
PLoS ONE, 2014, Volume 9, Number 6, Page e100468
[12]
Natalie R. Gassman
Environmental and Molecular Mutagenesis, 2017, Volume 58, Number 2, Page 60
[13]
T. L. L. Berge, G. B. Lygre, B. A. G. Jönsson, C. H. Lindh, and L. Björkman
Clinical Oral Investigations, 2017
[14]
Lucia Speroni, Maria Voutilainen, Marja L. Mikkola, Skylar A. Klager, Cheryl M. Schaeberle, Carlos Sonnenschein, and Ana M. Soto
Scientific Reports, 2017, Volume 7, Page 40806
[15]
Jone Corrales, Lauren A. Kristofco, W. Baylor Steele, Brian S. Yates, Christopher S. Breed, E. Spencer Williams, and Bryan W. Brooks
Dose-Response, 2015, Volume 13, Number 3, Page 155932581559830
[16]
L.A. Koneva, A.K. Vyas, R.C. McEachin, M. Puttabyatappa, H.-S. Wang, M.A. Sartor, and V. Padmanabhan
Environmental and Molecular Mutagenesis, 2017, Volume 58, Number 1, Page 4
[17]
Laura Gioiosa, Paola Palanza, Stefano Parmigiani, and Frederick S. vom Saal
Dose-Response, 2015, Volume 13, Number 4, Page 155932581561076
[18]
Fabiana Ariemma, Vittoria D’Esposito, Domenico Liguoro, Francesco Oriente, Serena Cabaro, Antonietta Liotti, Ilaria Cimmino, Michele Longo, Francesco Beguinot, Pietro Formisano, Rossella Valentino, and Angel Nadal
PLOS ONE, 2016, Volume 11, Number 3, Page e0150762
[19]
Alessandra Camarca, Carmen Gianfrani, Fabiana Ariemma, Ilaria Cimmino, Dario Bruzzese, Roberta Scerbo, Stefania Picascia, Vittoria D’Esposito, Francesco Beguinot, Pietro Formisano, Rossella Valentino, and Gernot Zissel
PLOS ONE, 2016, Volume 11, Number 8, Page e0161122
[20]
Catherine A. VandeVoort, Roy R. Gerona, Frederick S. vom Saal, Alice F. Tarantal, Patricia A. Hunt, Anne Hillenweck, Daniel Zalko, and Angel Nadal
PLOS ONE, 2016, Volume 11, Number 12, Page e0165410
[21]
Zhe Wang, Huiyu Liu, and Sijin Liu
Advanced Science, 2017, Volume 4, Number 2, Page 1600248
[22]
I. Porreca, L. Ulloa-Severino, P. Almeida, D. Cuomo, A. Nardone, G. Falco, M. Mallardo, and C. Ambrosino
Obesity Reviews, 2017, Volume 18, Number 1, Page 99
[24]
Arcangelo Barbonetti, Chiara Castellini, Noemi Di Giammarco, Gaetano Santilli, Sandro Francavilla, and Felice Francavilla
Reproductive Toxicology, 2016, Volume 66, Page 61
[25]
Syam S. Andra, Christine Austin, Juan Yang, Dhavalkumar Patel, and Manish Arora
Science of The Total Environment, 2016, Volume 572, Page 770
[26]
Michael S. Bloom, Evelyn Mok-Lin, and Victor Y. Fujimoto
Fertility and Sterility, 2016, Volume 106, Number 4, Page 857
[27]
Teresa Balbi, Silvia Franzellitti, Rita Fabbri, Michele Montagna, Elena Fabbri, and Laura Canesi
Environmental Pollution, 2016, Volume 218, Page 996
[28]
Ming-Yu Xie, Hong Ni, De-Sheng Zhao, Li-Ying Wen, Ke-Sheng Li, Hui-Hui Yang, Shu-Si Wang, Heng Zhang, and Hong Su
Reproductive Toxicology, 2016, Volume 65, Page 224
[29]
Ayşe Derya Buluş, Ali Aşci, Pinar Erkekoglu, Aylin Balci, Nesibe Andiran, and Belma Koçer-Gümüşel
Toxicology Mechanisms and Methods, 2016, Volume 26, Number 7, Page 493
[30]
Laura N Vandenberg, Wade V Welshons, Frederick S vom Saal, Pierre-Louis Toutain, and John Peterson Myers
Environmental Health, 2014, Volume 13, Number 1
[31]
Laura N Vandenberg, Roy R Gerona, Kurunthachalam Kannan, Julia A Taylor, Richard B van Breemen, Carrie A Dickenson, Chunyang Liao, Yang Yuan, Retha R Newbold, Vasantha Padmanabhan, Frederick S vom Saal, and Tracey J Woodruff
Environmental Health, 2014, Volume 13, Number 1
[33]
Ravi Naidu, Victor Andres Arias Espana, Yanju Liu, and Joytishna Jit
Chemosphere, 2016, Volume 154, Page 350
[34]
Justin G. Teeguarden, Nathan C. Twaddle, Mona I. Churchwell, and Daniel R. Doerge
Food and Chemical Toxicology, 2016, Volume 92, Page 129
[35]
Maede Ejaredar, Yoonshin Lee, Derek J Roberts, Reginald Sauve, and Deborah Dewey
Journal of Exposure Science and Environmental Epidemiology, 2017, Volume 27, Number 2, Page 175
[36]
Sergi Soriano, Cristina Ripoll, Paloma Alonso-Magdalena, Esther Fuentes, Ivan Quesada, Angel Nadal, and Juan Martinez-Pinna
Steroids, 2016, Volume 111, Page 12
[37]
Guergana Mileva, Stephanie Baker, Anne Konkle, and Catherine Bielajew
International Journal of Environmental Research and Public Health, 2014, Volume 11, Number 7, Page 7537
[38]
Cinzia Rocca, Sabrina Tait, Cristiana Guerranti, Luca Busani, Francesca Ciardo, Bruno Bergamasco, Laura Stecca, Guido Perra, Francesca Mancini, Roberto Marci, Giulia Bordi, Donatella Caserta, Silvano Focardi, Massimo Moscarini, and Alberto Mantovani
International Journal of Environmental Research and Public Health, 2014, Volume 11, Number 10, Page 10146
[39]
Michael S. Bloom, Romeo Micu, and Iulia Neamtiu
Current Epidemiology Reports, 2016, Volume 3, Number 1, Page 39
[40]
A.L. Heffernan, K. Thompson, G. Eaglesham, S. Vijayasarathy, J.F. Mueller, P.D. Sly, and M.J. Gomez
Talanta, 2016, Volume 151, Page 224
[41]
Kristina A. Thayer, Katie E. Pelch, Linda S. Birnbaum, and John R. Bucher
Endocrine Disruptors, 2016, Volume 4, Number 1, Page e1131032
[42]
I-Jen Wang, Chia-Yang Chen, and Carl-Gustaf Bornehag
International Journal of Hygiene and Environmental Health, 2016, Volume 219, Number 3, Page 311
[43]
Paola Palanza, Susan C Nagel, Stefano Parmigiani, and Frederick S vom Saal
Current Opinion in Behavioral Sciences, 2016, Volume 7, Page 69
[45]
Paolo Cocci, Francesco Alessandro Palermo, Luana Quassinti, Massimo Bramucci, Antonino Miano, and Gilberto Mosconi
Journal of Environmental Sciences, 2016, Volume 43, Page 48
[46]
Rebecca Simonne Hehn
Environmental Science & Technology, 2016, Volume 50, Number 1, Page 397
[47]
Sarah A. Johnson, Angela B. Javurek, Michele S. Painter, Mark R. Ellersieck, Thomas H. Welsh, Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, Sherry A. Ferguson, and Cheryl S. Rosenfeld
Hormones and Behavior, 2016, Volume 80, Page 139
[48]
Bridget F Healy, Karin R English, Paul Jagals, and Peter D Sly
Journal of Exposure Science and Environmental Epidemiology, 2015, Volume 25, Number 6, Page 544
[49]
Kristina A. Thayer, Daniel R. Doerge, Dawn Hunt, Shepherd H. Schurman, Nathan C. Twaddle, Mona I. Churchwell, Stavros Garantziotis, Grace E. Kissling, Michael R. Easterling, John R. Bucher, and Linda S. Birnbaum
Environment International, 2015, Volume 83, Page 107
[50]
[51]
Guo-min Wu, Di Liu, Gui-feng Liu, Jian Chen, Shu-ping Huo, and Zhen-wu Kong
Carbohydrate Polymers, 2015, Volume 127, Page 229
[52]
Md Saidur Rahman, Woo-Sung Kwon, June-Sub Lee, Sung-Jae Yoon, Buom-Yong Ryu, and Myung-Geol Pang
Scientific Reports, 2015, Volume 5, Number 1
[53]
Benjamin Lopez, Patrick Ollivier, Anne Togola, Nicole Baran, and Jean-Philippe Ghestem
Science of The Total Environment, 2015, Volume 518-519, Page 562
[54]
John D. Elsworth, James D. Jentsch, Stephanie M. Groman, Robert H. Roth, Eugene D. Redmond, and Csaba Leranth
Journal of Comparative Neurology, 2015, Volume 523, Number 8, Page 1248
[55]
Laura N. Vandenberg, Derek Luthi, and D.'Andre Quinerly
Journal of Cleaner Production, 2017, Volume 140, Page 373
[56]
Justin G. Teeguarden, Nathan C. Twaddle, Mona I. Churchwell, Xiaoxia Yang, Jeffrey W. Fisher, Liesel M. Seryak, and Daniel R. Doerge
Toxicology and Applied Pharmacology, 2015, Volume 288, Number 2, Page 131
[57]
Daniela M. Goldinger, Anne-Laure Demierre, Otmar Zoller, Heinz Rupp, Hans Reinhard, Roxane Magnin, Thomas W. Becker, and Martine Bourqui-Pittet
Regulatory Toxicology and Pharmacology, 2015, Volume 71, Number 3, Page 453
[58]
Soria Eladak, Tiphany Grisin, Delphine Moison, Marie-Justine Guerquin, Thierry N'Tumba-Byn, Stéphanie Pozzi-Gaudin, Alexandra Benachi, Gabriel Livera, Virginie Rouiller-Fabre, and René Habert
Fertility and Sterility, 2015, Volume 103, Number 1, Page 11
[60]
R.N. Sadowski, L.M. Wise, P.Y. Park, S.L. Schantz, and J.M. Juraska
Neuroscience, 2014, Volume 279, Page 122
[61]
Julia R. Barrett
Environmental Health Perspectives, 2014, Volume 122, Number 8, Page A223
[62]
[63]
A. Veiga-Lopez, E.M. Beckett, B. Abi Salloum, W. Ye, and V. Padmanabhan
Toxicology and Applied Pharmacology, 2014, Volume 279, Number 2, Page 119
[64]
R.E. FitzGerald and M.F. Wilks
Toxicology Letters, 2014, Volume 230, Number 2, Page 368
[65]
Nikki Gillum Posnack
Cardiovascular Toxicology, 2014, Volume 14, Number 4, Page 339
[67]
Teng Zhang, Lan Li, Xun-Si Qin, Yang Zhou, Xi-Feng Zhang, Lin-Qing Wang, Massimo De Felici, Hong Chen, Guo-Qing Qin, and Wei Shen
Environmental and Molecular Mutagenesis, 2014, Volume 55, Number 4, Page 343
[68]
Justin G. Teeguarden, Jeffrey W. Fisher, and Daniel R. Doerge
Environmental Health Perspectives, 2013, Volume 121, Number 11-12, Page A323
[69]
Virginie Migeot, Antoine Dupuis, Axelle Cariot, Marion Albouy-Llaty, Fabrice Pierre, and Sylvie Rabouan
Environmental Science & Technology, 2013, Volume 47, Number 23, Page 13791
[70]
Pavlovičová Michaela, Karmažínová Mária, Huláková Silvia, and Lacinová Ľubica
Naunyn-Schmiedeberg's Archives of Pharmacology, 2014, Volume 387, Number 2, Page 153
[71]
Laura N Vandenberg, Shelley Ehrlich, Scott M Belcher, Nira Ben-Jonathan, Dana C Dolinoy, Eric R Hugo, Patricia A Hunt, Retha R Newbold, Beverly S Rubin, Katerine S Saili, Ana M Soto, Hong-Sheng Wang, and Frederick S vom Saal
Endocrine Disruptors, 2013, Volume 1, Number 1, Page e26490
[73]
Justin Teeguarden, Sesha Hanson-Drury, Jeffrey W. Fisher, and Daniel R. Doerge
Food and Chemical Toxicology, 2013, Volume 62, Page 949
[74]
Julia R. Barrett
Environmental Health Perspectives, 2013, Volume 121, Number 8, Page a257

Comments (0)

Please log in or register to comment.
Log in