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Reviews on Environmental Health

Editor-in-Chief: Carpenter, David O. / Sly, Peter

Editorial Board: Brugge, Doug / Edwards, John W. / Field, R.William / Garbisu, Carlos / Hales, Simon / Horowitz, Michal / Lawrence, Roderick / Maibach, H.I. / Shaw, Susan / Tao, Shu / Tchounwou, Paul B.


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2191-0308
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Volume 31, Issue 3

Issues

Exposure to pesticides and prostate cancer: systematic review of the literature

João F.S. Silva
  • Corresponding author
  • Federal University of Mato Grosso do Sul (UFMS), School of Medicine (FAMED), Campo Grande, Mato Grosso do Sul, Brazil
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Inês E. Mattos
  • Oswaldo Cruz Foundation, Department of Epidemiology and Quantitative Methods, Rio de Janeiro, RJ, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laércio L. Luz
  • Oswaldo Cruz Foundation, Department of Epidemiology and Quantitative Methods, Rio de Janeiro, RJ, Brazil
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  • De Gruyter OnlineGoogle Scholar
/ Cleber N. Carmo
  • Oswaldo Cruz Foundation, Department of Epidemiology and Quantitative Methods, Rio de Janeiro, RJ, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ricardo D. Aydos
  • Federal University of Mato Grosso do Sul, Graduate Program and Development in the Central West Region, Campo Grande, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-05-31 | DOI: https://doi.org/10.1515/reveh-2016-0001

Abstract

Introduction:

Investigations about the association between prostate cancer and environmental and/or occupational pesticide exposure have evidenced a possible role of these chemical substances on tumor etiology, related to their action as endocrine disruptors.

Objective:

To assess the association between pesticide exposure and prostate cancer by conducting a systematic review of the scientific literature.

Materials and methods:

Articles published until August 18, 2015 were searched in the databases MEDLINE/Pubmed, Scielo, and Lilacs using the keywords “pesticides” and “prostate cancer”. Only the analytical observational studies whose methodological quality met the criteria established by the New Castle-Ottawa scale were included in this review.

Results:

The review included 49 studies published between 1993 and 2015. All studies were in English and analyzed exposure to pesticides and/or agricultural activities. Most studies (32 articles) found a positive association between prostate cancer and pesticides or agricultural occupations, with estimates ranging from 1.01 to 14.10.

Conclusion:

The evidence provided by the reviewed studies indicates a possible association between the development of prostate cancer and pesticide exposure and/or agricultural occupations.

Keywords: agriculture; environmental exposure; occupational exposure

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About the article

Received: 2016-01-18

Accepted: 2016-04-22

Published Online: 2016-05-31

Published in Print: 2016-09-01


Citation Information: Reviews on Environmental Health, Volume 31, Issue 3, Pages 311–327, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: https://doi.org/10.1515/reveh-2016-0001.

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