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Reviews on Environmental Health

Editor-in-Chief: Carpenter, David O. / Sly, Peter

Editorial Board: Brugge, Doug / Edwards, John W. / Field, R.William / Garbisu, Carlos / Hales, Simon / Horowitz, Michal / Lawrence, Roderick / Maibach, H.I. / Shaw, Susan / Tao, Shu / Tchounwou, Paul B.

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Volume 31, Issue 4

Issues

Hormonally active agents in the environment: a state-of-the-art review

Faizan Anwer
  • Jamia Millia Islamia, A Central University, New Delhi 110025, India
  • IMS Engineering College, Ghaziabad 201009, Dr. A.P.J. Abdul Kalam Technical University, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Savita Chaurasia / Abid Ali Khan
Published Online: 2016-08-03 | DOI: https://doi.org/10.1515/reveh-2016-0014

Abstract

After the Second World War, infatuation with modern products has exponentially widened the spectrum of chemicals used. Some of them are capable of hijacking the endocrine system by blocking or imitating a hormone and are referred to as hormonally active chemicals or endocrine disruptors. These are chemicals that the body was not designed for evolutionarily and they are present in every matrix of the environment. We are living in a chemical world where the exposures are ubiquitous and take place in combinations that can interact with the endocrine system and some other metabolic activities in unexpected ways. The complexity of interaction of these compounds can be understood by the fact that they interfere with gene expression at extremely low levels, consequently harming an individual life form, its offspring or population. As the endocrine system plays a critical role in many biological or physiological functions, by interfering body’s endocrine system, endocrine disrupting compounds (EDCs) have various adverse effects on human health, starting from birth defects to developmental disorders, deadly deseases like cancer and even immunological disorders. Most of these compounds have not been tested yet for safety and their effects cannot be assessed by the available techniques. The establishment of proper exposure measurement techniques and integrating correlation is yet to be achieved to completely understand the impacts at various levels of the endocrine axis.

Keywords: alkyl-phenols; bisphenol A (BPA); dioxins; endocrine disrupting compounds (EDCs); PAH; PCB; phthalates

References

  • 1.

    Schwartz NB. Perspective: reproductive endocrinology and human health in the 20th century – a personal retrospective. Endocrinology 2001;142(6):2163–6.PubMedCrossrefGoogle Scholar

  • 2.

    De Rosa C, Richter P, Pohl H, Jones DE. Environmental exposures that affect the endocrine system: public health implications. J Toxicol Environ Health B Crit Rev 1998;1(1):3–26.CrossrefPubMedGoogle Scholar

  • 3.

    Carson R, Books M, editors. Silent spring, 40th ed. United States: Mariner Books, Houghton Mifflin Company, 2002.Google Scholar

  • 4.

    Colborn T, Dumanoski D, Myers JP. Our stolen future: are we threatening our fertility, intelligence, and survival? – A scientific detective story. New York: Dutton, 1996:306.Google Scholar

  • 5.

    Twombly R. Assault on the male. Environ Health Perspect 1995;103(9):802–5.CrossrefPubMedGoogle Scholar

  • 6.

    Gavrilescu M, Demnerova K, Aamand J, Agathos S, Fava F. Emerging pollutants in the environment: present and future challenges in biomonitoring, ecological risks and bioremediation. New Biotechnol 2014;32(1):147–56.Google Scholar

  • 7.

    Damstra T, Barlow S, Bergman A, Kavlock R, Van der Kraak G. Global Assessment of the State-of-the-science of Endocrine Disruptors. WHO publication no. WHO/PCS/EDC/02.2. World Health Organization, Geneva, Switzerland, 2002.Google Scholar

  • 8.

    European Commission Report. Identification of priority hazardous substances. Stockholm Convention 2001. Brussels, January 16, Adonis no. 901019; 2001.Google Scholar

  • 9.

    Colborn T, Vom Saal FS, Soto AM. Developmental effects of endocrine disrupting chemicals in wildlife and humans. Environ Health Perspect 1993;101(5):378–84.CrossrefPubMedGoogle Scholar

  • 10.

    Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, et al. Endocrine-disrupting chemicals: an endocrine-society scientific statement. Endocr Rev 2009;30(4):293–342.CrossrefPubMedGoogle Scholar

  • 11.

    US Environmental Protection Agency. Goldman L. Partnerships to strengthen efforts to prevent breast cancer. Available at: http://www.epa.gov/oppt/library/pubs/archive/oppts speeches/hhsbcfi.htm, 1998.

  • 12.

    Servos MR. Review of the aquatic toxicity, estrogenic responses and bioaccumulation of alkylphenols and alkylphenol polyethoxylates. Water Qual Res J Can 1999;34(1):123–77.Google Scholar

  • 13.

    Caliman FA, Gavrilescu M. Pharmaceuticals, personal care products and endocrine disrupting agents in the environment – a review. Clean 2009;37(4–5):277–303.Google Scholar

  • 14.

    Preda C, Ungureanu MC, Vulpoi C. Endocrine disruptors in the environment and their impact on human health. Environ Eng Manag J 2012;11(9):1697–706.Google Scholar

  • 15.

    Ying GG, Williams B, Kookana R. Environmental fate of alkylphenols and alkylphenol ethoxylates – a review. Environ Int 2002;28(3):215–26.CrossrefPubMedGoogle Scholar

  • 16.

    Esperanza M, Suidan MT, Nishimura F, Wang Z-M, Sorial GA, et al. Determination of sex hormones and nonylphenol ethoxylates in the aqueous matrixes of two pilot-scale municipal wastewater treatment plants. Environ Sci Technol 2004;38(11):3028–35.CrossrefPubMedGoogle Scholar

  • 17.

    Boyd GR, Reemtsma H, Grimm DA, Mitra S. Pharmaceuticals and personal care products (PPCPs) in surface and treated waster of Louisiana, USA and Otario, Canada. Sci Total Environ 2003;311(1–3):135–49.CrossrefGoogle Scholar

  • 18.

    EU Parliament and Council. Proposal for a directive of the European Parliament and of the Council on environmental quality standards in the field of water policy and amending. Directive 2000/60/EC (presented by the Commission) [COM(2006), 398 final, SEC(2006) 947], Brussels, 17.7.2006, COM(2006) 397 final.

  • 19.

    EC, Directive of the European Parliament and of the Council 2000/60/EC establishing a framework for community action in the field of water policy, Official Journal, 2000, C513, 23/10/2000.

  • 20.

    Rosenfeld PE, Feng LGH, editors. Risks of hazardous wastes. Amsterdam: Elsevier, 2011.Google Scholar

  • 21.

    Akhtar N, Kayani SA, Ahmad MM, Shahab M. Insecticide-induced changes in secretory activity of the thyroid gland in Rats. J Appl Toxicol 1996;16(5):397–400.CrossrefPubMedGoogle Scholar

  • 22.

    Brittebo EB, Kowalski B, Brand I. Binding of the aliphatic halides 1,2-dibromoethane and chloroform in the rodent vaginal epithelium. Pharmacol Toxicol 1987;60(4):294–8.PubMedCrossrefGoogle Scholar

  • 23.

    Krishnan V, Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. Toxicol App Pharmacol 1993;120(1):55–61.CrossrefGoogle Scholar

  • 24.

    Klinge CM, Bowers JL, Kulakosky PC, Kumboj KK, Swanson HI. The aryl hydrocarbon receptor (AHR/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response element. Mol Cell Endocrinol 1999;157(1–2):105–19.CrossrefPubMedGoogle Scholar

  • 25.

    Sandau CD, Meerts IATM, Letcher RJ, McAlees AJ, Chittim B, et al. Identification of 4-hydroxyheptachlorostyrene in Polar Bear. Environ Sci Technol 2000;34(18):3871–7.Google Scholar

  • 26.

    Bahn AK, Mills JL, Snyder PJ, Gann PH, Houten L, et al. Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med 1980:302(1):31–3.PubMedCrossrefGoogle Scholar

  • 27.

    Henderson AK, Rosen D, Miller GL, Figgs LW, Zahm SH, et al. Breast cancer among women exposed to polybrominated biphenyls. Epidemiology 1995;6(5):544–6.PubMedCrossrefGoogle Scholar

  • 28.

    Korach KS, Sarver P, Chae K, McLachlan JA, McKinney JD. Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes. Mol Pharmacol 1988;33(1):120–6.PubMedGoogle Scholar

  • 29.

    Zoeller RT, Dowling AL, Vas AA. Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain. Endocrinology 2000;141(1):181–9.PubMedCrossrefGoogle Scholar

  • 30.

    Wolf C Jr, Lambright C, Mann P, Price M, Cooper RL, et al. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health 1999;15(1–2):94–118.PubMedGoogle Scholar

  • 31.

    Cheek AO, Kow K, Chen J, McLachlan JA. Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect 1999;107(4):273–8.CrossrefPubMedGoogle Scholar

  • 32.

    Ilonka A, Meerts TM, van Zanden JJ, Luijks EAC, van Leeuwen-Bol I, et al. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci 2000;56(1):95–104.CrossrefPubMedGoogle Scholar

  • 33.

    Beard AP, Rawlings NC. Thyorid function and effects on reproduction in ewes exposed to the organochlorine pesticides lindane or pentachlorophenol (PCP) from conception. J Toxicol Environ Health 1999;58(8):509–30.CrossrefGoogle Scholar

  • 34.

    Gerhard I, Frick A, Monga B, Runnebaum B. Pentachlorophenol exposure in women with gynecological and endocrine dysfunction. Envrion Res 1999;80(4):383–8.CrossrefGoogle Scholar

  • 35.

    Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. A Variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect 1995;103(6):582–7.PubMedCrossrefGoogle Scholar

  • 36.

    Hurley PM, Hill RN, Whiting RJ. Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect 1998;106(8):437–45.CrossrefPubMedGoogle Scholar

  • 37.

    Wilson AG, Thake DC, Heydens WE, Brewster DW, Hotz KJ. Mode of action of thyroid tumor formation in the male long-evans rat administered high doses of alachlor. Fundam Appl Toxicol 1996;33(1):16–23.CrossrefPubMedGoogle Scholar

  • 38.

    Jorgenson JL. Aldrin and dieldrin: a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States. Environ Health Perspect 2001;109(suppl 1):113–39.CrossrefPubMedGoogle Scholar

  • 39.

    Go V, Garey J, Wolff MS, Pogo BG. Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Environ Health Perspect 1999;107:173–7.CrossrefPubMedGoogle Scholar

  • 40.

    Danzo BJ. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect 1997;105(3):294–301.CrossrefPubMedGoogle Scholar

  • 41.

    Klotz DM, Arnold SF, McLachlan JA. Inhibition of 17 beta-estradiol and progesterone activity in human breast and endometrial cancer cells by carbamate insecticides. Life Sci 1997;60(17):1467–75.PubMedCrossrefGoogle Scholar

  • 42.

    Pickford DB, Morris ID. Effects of endocrine-disrupting contaminants on amphibian oogenesis: methoxychlor inhibits progesterone-induced maturation of xenopus laevis oocytes in vitro. Environ Health Perspect 1999;107(4):285–92.PubMedCrossrefGoogle Scholar

  • 43.

    Porter WP, Green SM, Debbink NL, Carlson I. Groundwater pesticides: interactive effects of low concentrations of carbamates aldicarb and methomyl and the triazine metribuzin on thyroxine and somatotropin levels in white rats. J Toxicol Environ Health 1993;40(1):15–34.PubMedCrossrefGoogle Scholar

  • 44.

    Chen TT, Reid PC, Van Beneden R, Sonsegard RA. Effect of Arochlor 1254 and Mirex on estradiol-induced vittellogenin production in juvenile rainbow trout. Can J Fish Aquat Sci 1986;43:169–73.CrossrefGoogle Scholar

  • 45.

    Stevens JT, Summer DD. Herbicides. In: Hayes WJ, Laws ER, editors. Handbook of pesticide toxicology. New York: Academic Press, 1991:10–88.Google Scholar

  • 46.

    Willingham E, Rhen T, Sakata JT, Crews D. Embryonic treatment with xenobiotics disrupts steroid hormone profiles in hatchling red-eared slider turtles (trachemys scripta elegans). Environ Health Perspect 2000;108(4):329–32.PubMedCrossrefGoogle Scholar

  • 47.

    Guillette LJ Jr, Brock JW, Rooney AA, Woodward AR. Serum concentrations of various environmental contaminants and their relationship to sex steroid concentrations and phallus size in juvenile american alligators. Arch Environ Contam Toxicol 1999;36(4):447–55.CrossrefPubMedGoogle Scholar

  • 48.

    Moore A, Waring CP. The effects of a synthetic pyrethroid pesticide on some aspects of reproduction in Atlantic salmon (Salmo salar L.). Aquat Toxicol 2001;52(1):1–12.CrossrefPubMedGoogle Scholar

  • 49.

    Soto AM, Chung KL, Sonnenschein C. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect 1994;102(4):380–3.PubMedCrossrefGoogle Scholar

  • 50.

    Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA, et al. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 1995;375(6532):581–5.CrossrefPubMedGoogle Scholar

  • 51.

    Vinggaard AM, Breinholt V, Larsen JC. Screening of selected pesticides for oestrogen receptor activation in vitro. Food Addit Contam 1999;16(12):533–42.CrossrefPubMedGoogle Scholar

  • 52.

    Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, et al. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 1995;103(Suppl 7):113–22.CrossrefPubMedGoogle Scholar

  • 53.

    Tamura H, Maness SC, Reischmann K, Dorman DC, Gray LE, et al. Androgen Receptor Antagonism by the Organophosphate Insecticide Fenitrothion. Toxicol Sci 2001;60(1):56–62.CrossrefPubMedGoogle Scholar

  • 54.

    Reuber MD. Carcinogenicity of heptachlor and heptachlor epoxide. J Environ Pathol Toxicol Oncol 1987;7(3):85–114.PubMedGoogle Scholar

  • 55.

    Benhamed M. Report INSERM Unite 407/96001 Lyon, of October 21, 1996. Unpublished. Ownership: Rhone-Poulenc Agro, 1996.Google Scholar

  • 56.

    Waller CL, Juma BW, Gray LE Jr, Kelce WR. Three-dimensional quantitative structure-activity relationships for androgen receptor ligands. Toxicol Appl Pharm 1996;137(2):219–27.CrossrefGoogle Scholar

  • 57.

    Marty MS, Crissman JW, Carney EW. Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta- estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor. Toxicol Sci 1999;52(2):269–77.CrossrefGoogle Scholar

  • 58.

    Marty MS, Crissman JW, Carney EW. Evaluation of the male pubertal onset assay to detect testosterone and steroid biosynthesis inhibitors in CD Rats. Toxico Sci 2001;60(2):285–95.CrossrefGoogle Scholar

  • 59.

    Lambright C, Ostby J, Bobseine K, Wilson V, Hotchkiss AK, et al. Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats. Toxicol Sci 2000;56(2):389–99.PubMedCrossrefGoogle Scholar

  • 60.

    Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, et al. Male reproductive health and environmental chemicals with estrogenic effects. Miljoprojekt nr. 290. Report of the Ministry of Environment and Energy. Copenhagen: Danish environmental protection agency, 1995.Google Scholar

  • 61.

    Stoker TE, Goldman JM, Cooper RL. The dithiocarbamate fungicide thiram disrupts the hormonal control of ovulation in the female rat. Reprod Toxicol 1993;7:211–8.CrossrefPubMedGoogle Scholar

  • 62.

    Horiguchi T, Takiguchi N, Cho HS, Kojima M, Kaya M, et al. Ovo-testis and disturbed reproductive cycle in the giant abalone, Haliotis madaka: possible linkage with organotin contamination in a site of population decline. Mar Environ Res 2000;50(1–5):223–9.CrossrefGoogle Scholar

  • 63.

    Rawlings NC, Cook SJ, Waldbillig D. Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes. J Toxicol Environ Health Part A 1998;54(1):21–36.CrossrefPubMedGoogle Scholar

  • 64.

    Marinovich MM, Guizzetti F, Ghilardi F, Viviani B, Corsini E, et al. Thyroid peroxidase as toxicity target for dithiocarbamates. Arch Toxicol 1997;71(8):508–12.PubMedCrossrefGoogle Scholar

  • 65.

    Harris CA, Henttu P, Parker MG, Sumpter JP. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect 1997;105(8):802–11.PubMedCrossrefGoogle Scholar

  • 66.

    Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption, Final report, BKH Consulting Engineers, Delft, November 2000.

  • 67.

    Brooke D, Crookes M, Johnson I, Mitchell R, Watts C. Prioritisation of alkylphenols for environmental risk assessment. Bristol, England: National Centre for Ecotoxicology and Hazardous Substances, Environment Agency, 2005.Google Scholar

  • 68.

    Hong CC, Shimomura-Shimizu M, Muroi M, Tanamoto K. Effect of endocrine disrupting chemicals on lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by mouse macrophages. Biol Pharm Bull 2004;27(7):1136–9.CrossrefPubMedGoogle Scholar

  • 69.

    Ademollo N, Ferrara F, Delise M, Fabietti F, Funari E. Nonylphenol and octylphenol in human breast milk. Environ Int 2008;34:984–7.CrossrefPubMedGoogle Scholar

  • 70.

    Lopez-Espinosa MJ, Freire C, Arrebola JP, Navea N, Taoufiki J, et al. Nonylphenol and octylphenol in adipose tissue of women in Southern Spain. Chemosphere 2009;76(6):847–52.PubMedCrossrefGoogle Scholar

  • 71.

    Chen ML, Chang CC, Shen YJ, Hung JH, Guo BR, et al. Quantification of prenatal exposure and maternal–fetal transfer of nonylphenol. Chemosphere 2008;73(Suppl 1):S239–45.PubMedCrossrefGoogle Scholar

  • 72.

    Liu M, Hashi Y, Pan F, Yao J, Song G, et al. Automated online liquid chromatography–photodiode array–mass spectrometry method with dilution line for the determination of bisphenol A and 4-octylphenol in serum. J Chromatogr A 2006;1133(1–2):142–8.CrossrefGoogle Scholar

  • 73.

    Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environ Health Perspect 2008;116(1):39–44.PubMedGoogle Scholar

  • 74.

    Ferrara F, Ademollo N, Delise M, Fabietti F, Funari E. Alkylphenols and their ethoxylates in seafood from the Tyrrhenian Sea. Chemosphere 2008;72(9):1279–85.PubMedCrossrefGoogle Scholar

  • 75.

    Jonkers N, Laane RWPM, De Voogt P. Fate of nonylphenol ethoxylates and their metabolites in two Dutch estuaries: evidence of biodegradation in the field. Environ Sci Technol 2003;37(2):321–7.CrossrefPubMedGoogle Scholar

  • 76.

    Gray MA, Niimi AJ, Metcalfe CD. Factors affecting the development of testis-ova in medaka, Oryzias latipes, exposed to octylphenol. EnvironToxicol Chem 1999;18(8):1835–42.Google Scholar

  • 77.

    Knaak JB, Elridge JM, Sullivan LJ. Excretion of certain polyethylene glycol ether adducts of nonylphenol by the rat. Toxicol Appl Pharm 1966;9(2):331–40.CrossrefGoogle Scholar

  • 78.

    Warhurst AM. An environmental assessment of alkylphenol ethoxylates and alkylphenols. Published jointly by Friends of the Earth, Scotland and Friends of the Earth, England, Wales and Northern Ireland, 1995.Google Scholar

  • 79.

    CEPA – Canada Environmantal Protection Act, Priority Substances List Assessment Report-Nonylphenol and Its Ethoxylates, Environment Canada, Health Canada, 1999.Google Scholar

  • 80.

    Soares A, Guieysse B, Jefferson B, Cartmell E, Lester JN. Nonylphenol in the environment: a critical review on occurrence, fate, toxicity and treatment in wastewaters. Environ Int 2008;34(7):1033–49.CrossrefPubMedGoogle Scholar

  • 81.

    Ahel M, Giger W. Aqueous solubility of alkylphenols and alkylphenol polyethoxylates. Chemosphere 1993;26(8):1461–70.CrossrefGoogle Scholar

  • 82.

    Soto AM, Honorato J, Wray JW, Sonnenschein C. p-Nonyl-phenol: an estrogenic xenobiotic released from “modified” polystyrene. Environ Health Perspect 1991;92:167–73.PubMedCrossrefGoogle Scholar

  • 83.

    Porter AJ, Hayden NJ. Nonylphenol in the environment: a critical review. 2002. See http://www.emba.uvm.edu/wnhayden/npreview.pdf.

  • 84.

    Birkett JW, Lester JN. Endocrine disrupters in wastewater and sludge treatment processes. USA: Lewis Publishers, 2003.Google Scholar

  • 85.

    Aparicio I, Santos JL, Alonso E. Simultaneous sonication-assisted extraction, and determination by gas chromatography–mass spectrometry, of di-(2-ethylhexyl)phthalate, nonylphenol, nonylphenol ethoxylates and polychlorinated biphenyls in sludge from wastewater treatment plants. Analytica Chemica Acta 2007;584(2):455–61.CrossrefGoogle Scholar

  • 86.

    Olkowska E, Polkowska Z, Namiesnik J. Analytical procedures for the determination of surfactants in environmental samples. Talanta 2012;88(1):1–13.PubMedCrossrefGoogle Scholar

  • 87.

    Arditsoglou A, Voutsa D. Determination of phenolic and steroid endocrine disrupting compounds in environmental matrices. Environ Sci Pollut Res Int 2008;15(3):228–36.CrossrefPubMedGoogle Scholar

  • 88.

    Jeannot R, Sabik H, Sauvard E, Dagnac T, Dohrendorf K. Determination of endocrine-disrupting compounds in environmental samples using gas and liquid chromatography with mass spectrometry. J Chromatogr A 2002;974(1–2):143–59.PubMedCrossrefGoogle Scholar

  • 89.

    Johnson AC, Aerni HR, Gerritsen A, Gibert M, Giger W, et al. Comparing steroid estrogen and nonyl-phenol content across a range of European sewage plants with different treatment and management practices. Water Res 2005;39(1):47–58.CrossrefGoogle Scholar

  • 90.

    Stopper H, Schmitt E, Kobras K. Genotoxicity of phytoestrogens. Mutat Res 2005;574(1–2):139–55.CrossrefPubMedGoogle Scholar

  • 91.

    Burton JL, Wells M. The effect of phytoestrogens on the female genital tract. J Clin Pathol 2002;55(6):401–7.CrossrefPubMedGoogle Scholar

  • 92.

    Han DH, Denison MS, Tachibana H, Yamada K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem 2002;66(7):1479–87.PubMedCrossrefGoogle Scholar

  • 93.

    Nikov GN, Hopkins NE, Boue S, Alworth WL. Interactions of dietary estrogens with human estrogen receptors and the effect on estrogen receptor-estrogen response element complex formation. Environ Health Perspect 2000;108(9):867–72.PubMedCrossrefGoogle Scholar

  • 94.

    Kuiper-Goodman T, Scott PM, Watanabe H. Risk assessment of the mycotoxin zearalenone. Regulat Toxicol Pharmacol 1987;7(3):253–306.CrossrefGoogle Scholar

  • 95.

    Kurzer MS, Xu X. Dietary phytoestrogens. Ann Rev Nutr 1997;17:353–81.CrossrefGoogle Scholar

  • 96.

    Hess-Wilson JK, Knudsen KE. Endocrine disrupting compounds and prostate cancer. Cancer Lett 2006;241(1):1–12.PubMedCrossrefGoogle Scholar

  • 97.

    Matsumura A, Ghosh A, Pope GS, Darbre PD. Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol 2005;94(5):431–43.CrossrefPubMedGoogle Scholar

  • 98.

    Meeker JD, Ferguson KK. Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007–2008. Environ Health Perspect 2011;119(10):1396–402.CrossrefPubMedGoogle Scholar

  • 99.

    Sheng ZG, Tang Y, Liu YX, Yuan Y, Zhao BQ, et al. Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism. Toxicol Appl Pharmacol 2011;259(1):133–42.PubMedGoogle Scholar

  • 100.

    Staples CA, Peterson DR, Parkerton TF, Adams WJ. The environmental fate of phthalate esters. Chemosphere 1997;35(4):667–749.CrossrefGoogle Scholar

  • 101.

    Morteani G, Moller P, Fuganti A, Paces T. Input and fate of anthropogenic estrogens and gadoliniumin surface water and sewage plants in the hydrological basin of Prague (Czech Republic). Environ Geochem Health 2006;28(3):257–64.PubMedCrossrefGoogle Scholar

  • 102.

    Wyde ME, Kirwan SE, Zhang F, Laughter A, Hoffman HB, et al. Di-n- butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rate fetuse. Toxicol Sci 2005;86(2):281–90.CrossrefGoogle Scholar

  • 103.

    Cooper J, Dobson H. The benefits of pesticides to mankind and the environment. Crop Protection 2007;26(9):1337–48.CrossrefGoogle Scholar

  • 104.

    Mnif W, Hadj Hassine AI, Bouaziz A, Bartegi A, Thomas O, et al. Effect of endocrine disruptor pesticides: a review. Int J Environ Pub Health 2011;8(6):2265–303.CrossrefGoogle Scholar

  • 105.

    Bell EM, Hertz-Picciotto I, Beaumont JJA. Case-control study of pesticides and fetal death due to congenital anomalies. Epidemiology 2001;12(2):148–56.PubMedCrossrefGoogle Scholar

  • 106.

    Singer PL. Occupational oligospermia. J Am Med Assoc 1949;140:1249.Google Scholar

  • 107.

    Alavanja MC, Samanic C, Dosemici M, Lubin J, Tarone R, et al. Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol 2003;157(9):800–14.PubMedCrossrefGoogle Scholar

  • 108.

    Baskin LS, Himes K, Colborn T. Hypospadias and endocrine disruption: is there a connection? Environ Health Perspect 2001;109(11):1175–83.CrossrefGoogle Scholar

  • 109.

    Schreinemachers DD. Birth malformations and other adverse perinatal outcomes in four US wheat-producing states. Environ Health Perspect 2003;111(9):1259–64.CrossrefGoogle Scholar

  • 110.

    Zala S, Penn DJ. Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges. Anim Behav 2004;68(4):649–64.CrossrefGoogle Scholar

  • 111.

    Crain DA, Guillette LJ, Pickford DB, Rooney A. Alterations in steroidogenesis in alligators (alligator mississippiensis) exposed naturally and experimentally to environmental contaminants. Environ Health Perspect 1997;105(5):528–33.PubMedCrossrefGoogle Scholar

  • 112.

    Vos J, Dbing E, Greim HA, Ladefoge O, Lambré C, et al. Health effects of the endocrine-disrupting chemicals on wildlife, with special reference to European situation. Crit Rev Toxicol 2000;30(1):71–133.CrossrefPubMedGoogle Scholar

  • 113.

    Coat S, Monti D, Legendre P, Bouchon C, Massat F, et al. Organochlorine pollution in tropical rivers (Guadeloupe): role of ecological factors in food web bioaccumulation. Environ Pollut 2001;159(6):1692–701.Google Scholar

  • 114.

    Whitehead SA, Rice S. Endocrine disrupting chemicals as modulators of sex steroid synthesis. Best Pract Res Clin Endocrinol Metab 2006;20(1):45–61.CrossrefPubMedGoogle Scholar

  • 115.

    Damstra T. Potential effects of certain persistent organic pollutants and endocrine disrupting chemicals on the health of children. J Toxicol Clin Toxicol 2002;40(4):457–65.PubMedCrossrefGoogle Scholar

  • 116.

    Whitlock JP Jr. Mechanistic aspects of dioxin action. Chem Res Toxicol 1993;6(6):754–63.PubMedCrossrefGoogle Scholar

  • 117.

    Moore M, Mustain M, Daniel K, Chen I, Safe S, et al. Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicol Appl Pharmacol 1997;142(1):160–8.PubMedCrossrefGoogle Scholar

  • 118.

    Kabzinski AKM, Cyran J, Juszczak R. Determination of polycyclic aromatic hydrocarbons in water (including drinking water) of Lodz. Polish J Environ Studies 2002;11(6):695–706.Google Scholar

  • 119.

    Santodonato J. Review of the estrogenic and antiestrogenic activity of polycyclic aromatic hydrocarbons: relationship to carcinogenicity. Chemosphere 1997;34(4):835–48.CrossrefPubMedGoogle Scholar

  • 120.

    Choi H, Rauh V, Garfinkel R, Tu Y, Perera FP. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction. Environ Health Perspect 2008;116(5):658–65.PubMedCrossrefGoogle Scholar

  • 121.

    Perera FP, Tang D, Rauh V, Tu YH, Tsai WY, et al. Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center cohort. Environ Health Perspect 2007;115(10):1497–502.PubMedGoogle Scholar

  • 122.

    Poiger T, Buser HR, Balmer ME, Bergqvist PA, Muller MD. Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes. Chemosphere 2004;55(7):951–63.CrossrefPubMedGoogle Scholar

  • 123.

    Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, et al. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect 2001;109(3):239–44.CrossrefPubMedGoogle Scholar

  • 124.

    Inui M, Adachi T, Takenaka S, Inuia H, Nakazawaa M, et al. Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes). Toxicology 2003;194(1–2):43–50.CrossrefPubMedGoogle Scholar

  • 125.

    Schmutzler C, Bacinski A, Ambrugger P, Huhne K, Gruter A, et al. Thyroid hormone biosynthesis is a sensitive target for the action of endocrine disrupting chemicals. Exp Clin Endocrinol Diab 2006;114:S14.Google Scholar

  • 126.

    Schmutzler C, Gotthardt I, Hofmann PJ, Radovic B, Kovacs G, et al. Endocrine disruptors and the thyroid gland: a combined in vitro and in vivo analysis of potential new biomarkers. Environ Health Perspect 2007;115(Suppl 1):77–83.CrossrefPubMedGoogle Scholar

  • 127.

    Duedahl-Olesen L, Cederberg T, Høgsbro Pedersen K, Højgard A. Synthetic musk fragrances in trout from Danish fish farms and human milk. Chemosphere 2005;61(3):422–31.CrossrefPubMedGoogle Scholar

  • 128.

    Rimkus GG. Polycyclic musk fragrances in the aquatic environment. Toxicol Lett 1999;111(1–2):37–56.CrossrefPubMedGoogle Scholar

  • 129.

    Schreurs RHMM, Legler J, Artola-Garicano E, Sinnige TL, Lanser PH, et al. In vitro and in vivo antiestrogenic effects of polycyclic musks in zebrafish. Environ Sci Technol 2004;38(4):997–1002.PubMedCrossrefGoogle Scholar

  • 130.

    Schreurs RHMM, Quaedackers ME, Seinen W, Van der Burg B. Transcriptional activation of estrogen receptor ERa and ERb by polycyclic musks is cell type dependent. Toxicol Appl Pharmacol 2002;183(1):1–9.CrossrefGoogle Scholar

  • 131.

    Doron S, Friedman M, Falach M, Sadovnic E, Zvia H. Antibacterial effect of parabens against planktonic and biofilm Streptococcus sobrinus. Int J Antimicrob Agents 2001;18(6):575–8.CrossrefPubMedGoogle Scholar

  • 132.

    Lee HB, Peart TE, Svoboda ML. Determination of endocrinedisrupting phenols, acidic pharmaceuticals, and personal-care products in sewage by solid-phase extraction and gas chromatography-mass spectrometry. J Chromatogr A 2005;1094(1–2):122–9.Google Scholar

  • 133.

    Canosa P, Rodrıguez I, Rubı E, Bollaın MH, Cela R. Optimisation of a solid-phase microextraction method for the determination of parabens in water samples at the low ng per litre level. J Chromatogr A 2006;1124(1–2):3–10.Google Scholar

  • 134.

    Núñez L, Tadeo JL, García-Valcárcel AI, Turiel E. Determination of parabens in environmental solid samples by ultrasonic-assisted extraction and liquid chromatography with triple quadrupole mass spectrometry. J Chromatogr A 2008;1214(1–2):178–82.CrossrefPubMedGoogle Scholar

  • 135.

    Soni MG, Carabin IG, Burdock GA. Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food Chem Toxicol 2005;43(7):985–1015.PubMedCrossrefGoogle Scholar

  • 136.

    Darbre PD, Byford JR, Shaw LE, Horton RA, Pope GS, et al. Oestrogenic activity of isobutylparaben in vitro and in vivo. J Appl Toxicol 2002;22(4):219–26.CrossrefPubMedGoogle Scholar

  • 137.

    Darbre PD, Aljarrah A, Miller WR, Coldham NG, Sauer MJ, et al. Concentrations of parabens in human breast tumours. J Appl Toxicol 2004;24(1):5–13.CrossrefPubMedGoogle Scholar

  • 138.

    Harvey P, Darbre P. Endocrine disrupters and human health: could oestrogenic chemicals in body care cosmetics adversely affect breast cancer incidence in women? A review of evidence and call for further research. J Appl Toxicol 2004;24(3):167–76.CrossrefPubMedGoogle Scholar

  • 139.

    Byford JR, Shawa LE, Drewb MGB, Pope GS, Sauer MJ, e tal. Oestrogenic activity of parabens in MCF7 human breast cancer cells. J. Steroid Biochem. Mol Biol 2002;80(1):49–60.PubMedCrossrefGoogle Scholar

  • 140.

    Kang KS, Cho SD, Lee YS. Additive estrogenic activities of the binary mixtures of four estrogenic chemicals in recombinant yeast expressing human estrogen receptor. J Vet Sci 2002;3(1):1–5.PubMedGoogle Scholar

  • 141.

    Soto AM, Justicia H, Wray JW, Sonnenschein C. pNonyl-phenol: an estrogenic xenobiotic released from “modified” polystyrene. Environ Health Perspect 1991;92:167–73.PubMedCrossrefGoogle Scholar

  • 142.

    Sonnenschein C, Soto AM. An updated review of environmental estrogen and androgen mimics and antagonists. J Steroid Biochem Mol Biol 1998;65(1–6):143–50.CrossrefPubMedGoogle Scholar

  • 143.

    Achim B, Callum S, Tumo K. Contribution of European research to endocrine disruptors. Anal Chim Acta 2002;473(1–2):161–5.Google Scholar

  • 144.

    Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidencenfor decreasing quality of semen during past 50 years. BMJ 1992;305(6854):609–13.PubMedCrossrefGoogle Scholar

  • 145.

    Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993;341(8857):1392–5.PubMedCrossrefGoogle Scholar

  • 146.

    Whitehead ED, Leiter E. Genital abnormalities and abnormal semen analyses in male patients exposed to diethylstilbestrol in utero. J Urol 1981;125(1):47–50.PubMedCrossrefGoogle Scholar

  • 147.

    Dallinga JW, Moonen EJ, Dumoulin JC, Evers JL, Geraedts JP, et al. Decreased human semen quality and organochlorine compounds in blood. Hum Reprod 2002;17(8):1973–9.PubMedCrossrefGoogle Scholar

  • 148.

    Swan SH, Liu F, Overstreet JW, Brazil C, Skakkebaek NE. Semen quality of fertile US males in relation to their mothers’ beef consumption during pregnancy. Hum Reprod 2007;22(6):1497–502.CrossrefPubMedGoogle Scholar

  • 149.

    Foresta C, Zuccarello D, Garolla A, Ferlin A. Role of hormones, genes, and environment in human cryptorchidism. Endocrine Rev 2008;29(5):560–80.CrossrefGoogle Scholar

  • 150.

    Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, et al. Male reproductive health and environmental xenoestrogens. Environ Health Perspect 1996;104(Suppl 4):741–803.CrossrefPubMedGoogle Scholar

  • 151.

    Toppari J, Kaleva M, Virtanen HE. Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registrybased data. Hum Reprod Update 2001;7(3):282–6.PubMedCrossrefGoogle Scholar

  • 152.

    Virtanen HE, Bjerknes R, Cortes D, Jørgensen N, Rajpert-De Meyts E, et al. Cryptorchidism: classification, prevalence and long-term consequences. Acta Paediatr 2007;96(5):611–6.PubMedCrossrefGoogle Scholar

  • 153.

    Gray LE Jr, Wilson VS, Stoker T, Lambright C, Furr J, et al. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Int J Androl 2006;29(1):96–104.CrossrefPubMedGoogle Scholar

  • 154.

    Kristensen P, Irgens LM, Andersen A, Bye AS, Sundheim L. Birth defects among offspring of Norwegian farmers, 1967–1991. Epidemiology 1997;8(5):537–44.PubMedCrossrefGoogle Scholar

  • 155.

    Weidner IS, Moller H, Jensen TK, Skakkebæk NE. Cryptorchidism and hypospadias in sons of gardeners and farmers. Environ Health Perspect 1998;106(12):793–6.CrossrefPubMedGoogle Scholar

  • 156.

    Damgaard IN, Skakkebaek NE, Toppari J, Virtanen HE, Shen H, et al. Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect 2006;114(7):1133–8.CrossrefPubMedGoogle Scholar

  • 157.

    Nassar N, Abeywardana P, Barker A, Bower C. Parental occupational exposure to potential endocrine disrupting chemicals and risk of hypospadias in infants. Occup Environ Med 2010;67(9):585–9.CrossrefPubMedGoogle Scholar

  • 158.

    Beleza-Meireles A, Omrani D, Kockum I, Frisen L, Lagerstedt K, et al. Polymorphisms of estrogen receptor beta gene are associated with hypospadias. J Endocrinol Invest 2006;29(1):5–10.CrossrefPubMedGoogle Scholar

  • 159.

    Van der Zanden LF, van Rooij IA, Feitz WF, Vermeulen SH, Kiemeney LA, et al. Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? J Clin Endocrinol Metab 2010;95(5):2384–90.PubMedCrossrefGoogle Scholar

  • 160.

    Jensen TK, Toppari J, Keiding N, Skakkebaek NE. Do environmental oestrogens contribute to the decline in male reproductive health? Clin Chem 1995;41(12 Pt 2):1896–901.PubMedGoogle Scholar

  • 161.

    Berkowitz GS, Lapinski RH, Gobold JH, Dolgin SE, Holzman IR. Maternal and neonatal risk factors for cryptorchidism. Epidemiology 1995;6(2):127–31.PubMedCrossrefGoogle Scholar

  • 162.

    Adami HO, Bergström R, Mohner M, Zatónski W, Storm H, et al. Testicular cancer in nine northern European countries. Int J Cancer 1994;59(1):33–8.CrossrefPubMedGoogle Scholar

  • 163.

    Fisher JS. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular ysgenesis syndrome. Reproduction 2004;127(3):305–15.PubMedCrossrefGoogle Scholar

  • 164.

    Bergström R, Adami HO, Möhner M, Zatonski W, Storm H, et al. Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J Natl Cancer Inst 1996;88(11):727–33.CrossrefPubMedGoogle Scholar

  • 165.

    Vastermark A, Giwercman YL, Hagstromer O, De-Meyts ER, Eberhard J, et al. Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease. Eur J Cancer 2011;47(3):413–9.CrossrefPubMedGoogle Scholar

  • 166.

    Forman D, Moller H. Testicular cancer. Cancer Surv 1994;19–20:223–341.Google Scholar

  • 167.

    Toppari J, Larsen JC, Christiansen P, Giwereman A, Grandjean P, et al. Male reproductive health and environmental chemicals with estrogenic effects. Copenhagen: Danish Environmental Protection Agency, 1995.Google Scholar

  • 168.

    Unni E, Sun SH, Nan BC, McPhaul MJ, Cheskis B, et al. Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res 2004;64(19):7156–68.CrossrefPubMedGoogle Scholar

  • 169.

    Ndong JR, Blanchet P, Multigner L. Pesticides et cancer de la prostate: donnees epidemiologiques. Bull Cancer 2009;96(2):171–80.Google Scholar

  • 170.

    Multigner L, Ndong JR, Giusti A, Romana M, Delacroix-Maillard H, et al. Chlordecone exposure and risk of prostate cancer. J Clin Oncol 2010;28(21):3457–62.PubMedCrossrefGoogle Scholar

  • 171.

    Timms BG, Howdeshell KL, Barton L, Bradley S, Richter CA, et al. Estrogenic chemicals in plastic and oral contraceptivesdisrupt development of the fetal mouse prostate and urethra. Proc Natl Acad Sci USA 2005;102(19):7014–19.CrossrefGoogle Scholar

  • 172.

    Gupta C. The role of estrogen receptor, androgen receptor and growth factors in diethylstilbestrol-induced programming of prostate differentiation. Urol Res 2000;28(4):223–9.CrossrefPubMedGoogle Scholar

  • 173.

    Hess-Wilson JK. Bisphenol A may reduce the efficacy of androgen deprivation therapy in prostate cancer. Cancer Causes Control 2009;20(7):1029–37.CrossrefPubMedGoogle Scholar

  • 174.

    Crisp TM, Clegg ED, Cooper RL, Wood WP, Anderson DG, et al. Environmental endocrine disruption: an effect assessment and analysis. Environ Health Perspect 1998;106(1):11–56.CrossrefGoogle Scholar

  • 175.

    Keller-Byrne JE, Khuder SA, Schaub EA. Meta analyses of prostate cancer and farming. Am J Ind Med 1997;31(5):580–6.CrossrefPubMedGoogle Scholar

  • 176.

    Coleman MP, Estève J, Damiecki P, Arslan A, Renard H. Trends in Cancer Incidence and Mortality, I ARC Scientific Publications no. 121. International Agency for Research on Cancer, Lyon, 1993.Google Scholar

  • 177.

    Dewailly E, Dodin S, Verreault R, Ayotte P,Sauve L, et al. High organochlorine body burden in women with oestrogen receptor positive breast cancer. J Natl Cancer Inst 1994;86(3):232–4.PubMedCrossrefGoogle Scholar

  • 178.

    Colton T, Greenberg ER. Breast cancer in mothers prescribed diethylstilboestrol in pregnancy. Further follow-up. J Am Med Assoc 1993;269(16):2096–100.CrossrefGoogle Scholar

  • 179.

    Brown NM, Lamartiniere CA. Xenoestrogens alter mammary gland differential and cell proliferation in the rat. Environ Health Perspect 1995;103(7–8):708–13.CrossrefGoogle Scholar

  • 180.

    Kociba RJ, Keyes DG, Beyer JE, Carreon RM, Wade CE, et al. Results of a two year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharm 1978;46(2):279–303.CrossrefGoogle Scholar

  • 181.

    Forster C, Makela S, Warri A, Kietz S, Becker D, et al. Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci USA 2002;99(24):15578–83.CrossrefGoogle Scholar

  • 182.

    Bouskine A, Nebout M, Mograbi B, Brucker-Davis F, Roger C, et al. Estrogens promote human testicular germ cell cancer through a membrane- mediated activation of extra-cellular regulated kinase and protein kinase-A. Endocrinology 2008;149(2):565–73.CrossrefGoogle Scholar

  • 183.

    Aronson KJ, Miller AB, Woolcott CG, Sterns EE, McCready DR, et al. Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2000;9(1):55–63.PubMedGoogle Scholar

  • 184.

    Davis DL, Bradlow HL, Wolff M, Woodruff T, Hoel DG, et al. Hypothesis. Xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 1993;101(5):372–7.CrossrefPubMedGoogle Scholar

  • 185.

    Parron T, Alarcon R, Requena MDM, Hernandez A. Increased breast cancer risk in women with environmental exposure to pesticides. Toxicol Lett 2010;196(Suppl 1):S180.CrossrefGoogle Scholar

  • 186.

    Cohn BA. Developmental and environmental origins of breast cancer: DDT as a case study. Reprod Toxicol 2011;31(3):302–11.CrossrefPubMedGoogle Scholar

  • 187.

    Rochefort H, Balaguer P. Endocrine disruptors: are they carcinogens? Bull Acad Natl Med 2010;194:1159–63.PubMedGoogle Scholar

  • 188.

    Meeker JD. Exposure to environmental endocrine disrupting compounds and men’s health. Maturitas 2010;66(3):236–41.PubMedCrossrefGoogle Scholar

  • 189.

    Holloway M. An epidemic ignored. Endometrosis linked to dioxin and immunologic dysfunction. Sci Am 1994;270(4):24–6.Google Scholar

  • 190.

    Hill JA. Immunologic factors in endometriosis and endometriosis-associated reproductive failure, infertility and reproduction. Med Clin North Am 1992;3:583.Google Scholar

  • 191.

    Vessey MP, Villard-Mackintosh L, Painter R. Epidemiology of endometrosis in women attending family planning clinics. Br Med J 1993;306(6871):182–4.CrossrefGoogle Scholar

  • 192.

    Berger MJ, Alper MM. Intractable primary infertility in women exposed to diethylstilboestrol in utero. J Reprod Med 1986;31:231–5.PubMedGoogle Scholar

  • 193.

    Gerhard I, Runnebaum B. Grenzen der Hormonsubstitution bei Schadsoffbelastung und Fertilitatsstorungen. Zentblatt fur Gynakologie 1992;114(12):593–602.Google Scholar

  • 194.

    Boyd JA, Clark GC, Walmer DK, Patterson DG, Needham LL, et al. Endometriosis and the environment: biomarkers of toxin exposure. Conference on endometriosis 2000, May 15–17, 1995, Bethesda, National Institutes of Health, 1995.Google Scholar

  • 195.

    Rier SF, Martin DC, Bowman RE, Dmowski P, Becker JL. Endometriosis in Rhesus monkeys (Macaca mallata) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fund Appl Toxicol 1993;21:433–41.CrossrefGoogle Scholar

  • 196.

    Heilier JF, Donnez J, Lison D. Organochlorines and endometriosis: a mini-review. Chemosphere 2008;71(2):203–10.CrossrefPubMedGoogle Scholar

  • 197.

    Reddy BS, Rozati R, Reddy BV, Raman NV. Association of phthalate esters with endometriosis in Indian women. Br J Obstet Gynaecol 2006;113(5):515–20.CrossrefGoogle Scholar

  • 198.

    Cobellis L, Colacurci N, Trabucco E, Carpentiero C, Grumetto L. Measurement of bisphenol A and bisphenol B levels in human blood sera from healthy and endometriotic women. Biomed Chromatogr 2009;23(11):1186–90.CrossrefPubMedGoogle Scholar

  • 199.

    Swerdloff RS, Overstreet JW, Sokol RZ, Rajfer J. Infertility in the male. Ann Intern Med 1985;103(6 pt 1):906–19.CrossrefPubMedGoogle Scholar

  • 200.

    Wilcox AJ, Baird DD, Weinberg CR, Hornsby PP, Herbst AL. Fertility in men exposed prenatally to diethylstilboestrol. N Engl J Med 1995;332(21):1411–6.PubMedCrossrefGoogle Scholar

  • 201.

    Pines A, Cucos S, Ever-Hardani P, Ron M. Some organochlorine insecticide and polychlorinated biphenyl blood residues in fertile male in the general Israeli population of the middle 1980s. Arch Environ Contam Toxicol 1987;16:587–97.CrossrefGoogle Scholar

  • 202.

    Barnes AB, Colton T, Gundersen J, Noller KL, Tilley BC, et al. Fertility and outcome of pregnancy in women exposed in utero to diethylstilboestrol. N Eng J Med 1980;302(11):609–13.CrossrefGoogle Scholar

  • 203.

    Bibbo M, Gill WB, Azizi F, Blough R, Fang VS, et al. Follow-up study of male and female offspring of DES-exposed mothers. Obstet Gynecol 1977;49(1):1–8.PubMedGoogle Scholar

  • 204.

    Isselbacher KJ, Braunwald AB, Wilson JD, Martin JB, Fauci AS, et al. Harrison’s principles of internal medicine, 13th ed. New York: McGraw-Hill, 1994.Google Scholar

  • 205.

    Mocarelli P, Brambilla P, Gerthoux PM, Patterson Jr DG, Needham LL. Change in sex ratio with exposure to dioxin. Lancet 1996;348(9024):409.CrossrefPubMedGoogle Scholar

  • 206.

    Moller H. Change in male female ration among newborn infants in Denmark. Lancet 1996;348(9030):828–9.CrossrefGoogle Scholar

  • 207.

    Van der Pal-de Bruin KM, Verloove-Va nhorck SP, Roeleveld N. Change in male female ratio among newborn babies in Netherlands. Lancet 1997;349(9044):62.CrossrefPubMedGoogle Scholar

  • 208.

    Dickinson HO, Parker L. Why is the sex ratio falling in England and Wales. J Epidemiol Community Health 1996;50(2):227–8.CrossrefPubMedGoogle Scholar

  • 209.

    Allan BB, Brant R, Seidel JE, Jarrel JF. Declining sex ratios in Canada. Can Med Assoc J 1997;156(1):37–41.Google Scholar

  • 210.

    Tilson HA, Kodavanti PR. Neurochemical effects of polychlorinated biphenyls: an overview and identification of research needs. Neurotoxicology 1997;18(3):727–43.PubMedGoogle Scholar

  • 211.

    Koopman-Esseboom C, Morse DC, Weisglas-Kuperus N, Lutkeschipholt IJ, van der Paauw C, et al. Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res 1994;36(4):468–73.CrossrefPubMedGoogle Scholar

  • 212.

    Lans MC, Klasson-Wehler E, Willemsen M, Meussen E, Safe S, et al. Structure-dependent, competitive interaction of hydroxy-polycloribiphenyls, dibenzo-p-dioxins and dibenzofurans with human transthyretin. Chem Biol Interact 1993;88(1):7–21.CrossrefPubMedGoogle Scholar

  • 213.

    Hsu ST, Ma CI, Hsu SK, Wu SS, Hsu NHM, et al. Discovery and epidemiology of PCB poisoning in Taiwan: a four year follow-up. Environ Health Perspect 1985;59:5–10.PubMedCrossrefGoogle Scholar

  • 214.

    Koopman-Esseboom C, Weisglas-Kuperus N, de Ridder MA, Van der Paauw CG, Tuinstra LG, et al. Effects of polychlorinated biphenyl/dioxin exposure and feeding type of infants mental and psychomotor development. Pediatrics 1996;97(5):700–6.PubMedGoogle Scholar

  • 215.

    Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 1996;335(11):783–9.PubMedCrossrefGoogle Scholar

  • 216.

    Huisman M, Koopman-Esseboom C, Fidler V, Hadders-Algra M, van der Paauw CG, et al. Perinatal exposure to polychlorinated biphenyls and dioxins and its effects on neonatal neurological development. Early Hum Dev 1995;41:111–27.PubMedCrossrefGoogle Scholar

  • 217.

    Eriksson P, Jakobsson E, Fredriksson A. Developmental neurotoxicity of brominated flameretardants,polybro minated diphenyl ethers and tetrabromo-bis-phenol. A. Organohalogen Compds 1998;35:375–7.Google Scholar

  • 218.

    Lang TJ. Estrogen as an immunomodulator. Clin Immunol 2004;113(3):224–30.PubMedCrossrefGoogle Scholar

  • 219.

    Kanda N, Tamaki K. Estrogen enhances immunoglobulin production by human PBMCs. J Allergy Clin Immunol 1999;103(2 pt 1):282–8.CrossrefPubMedGoogle Scholar

  • 220.

    Vial T, Nicolas B, Descotes J. Clinical immunotoxicity of pesticides. J Toxicol Environ Health 1996;48:215–29.PubMedCrossrefGoogle Scholar

  • 221.

    Stiller-Winkler R, Hadnagy W, Leng G, Straube E, Idel H. Immunological parameters in humans exposed to pesticides in the agricultural environment. Toxicol Lett 1999;107(1–3):219–24.CrossrefPubMedGoogle Scholar

  • 222.

    Sawai C, Anderson K, Walser-Kuntz D. Effect of bisphenol A on murine immune function: modification of interferon, IgG2a, and disease symptoms in NZB×NZW F1 mice. Environ Health Perspect 2003;111(16):1883–7.CrossrefGoogle Scholar

  • 223.

    Bornehag CG, Nanberg E. Phthalate exposure and asthma in children. Int J Androl 2010;33(2):333–45.CrossrefPubMedGoogle Scholar

About the article

Corresponding author: Savita Chaurasia, Professor, Department of Biotechnology, IMS Engineering College, Ghaziabad 201009, Dr. A.P.J. Abdul Kalam Technical University, India


Received: 2016-04-01

Accepted: 2016-06-25

Published Online: 2016-08-03

Published in Print: 2016-12-01


Citation Information: Reviews on Environmental Health, Volume 31, Issue 4, Pages 415–433, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: https://doi.org/10.1515/reveh-2016-0014.

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