Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Reviews on Environmental Health

Editor-in-Chief: Carpenter, David O. / Sly, Peter

Editorial Board: Brugge, Doug / Edwards, John W. / Field, R.William / Garbisu, Carlos / Hales, Simon / Horowitz, Michal / Lawrence, Roderick / Maibach, H.I. / Shaw, Susan / Tao, Shu / Tchounwou, Paul B.


IMPACT FACTOR 2018: 1.616

CiteScore 2018: 1.69

SCImago Journal Rank (SJR) 2018: 0.508
Source Normalized Impact per Paper (SNIP) 2018: 0.664

Online
ISSN
2191-0308
See all formats and pricing
More options …
Volume 34, Issue 4

Issues

Arsenic exposure with reference to neurological impairment: an overview

Anupama Sharma / Sunil Kumar
  • Corresponding author
  • A-10 Radhey Kunj Apartment, Shahibaug, Ahmedabad 380004, India
  • Former Director-in-Charge, National Institute of Occupational Health (ICMR), Ahmedabad 380016, India
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-10-11 | DOI: https://doi.org/10.1515/reveh-2019-0052

Abstract

Arsenic (As) toxicity has become a public health and environmental problem, which is a serious issue in certain parts of the world. Many people are exposed to As through contaminated drinking water, food and soil, through occupation, etc. Chronic As exposure is linked to various hostile health effects including skin problems, cancer, diabetes, cardiovascular disease, reproductive and developmental and neurological problems in exposed subjects. Experimental existing data indicate that chronic As exposure affects the nervous system by impairing the nerve and brain tissues of the exposed animals, and clinical studies indicate that As exposure leads to both central nervous system and peripheral nervous system impairments and also causes depression, memory impairment and difficulty in problem solving, affects body coordination, etc. Various prenatal and postnatal studies with respect to As exposure also suggest that developing offspring and young children are susceptible to As exposure. The only solution to this serious health problem is to stop occupational As exposure and provide As free drinking water to the affected population.

Keywords: arsenic; central nervous system; cognitive; coordination; memory impairments; neurological disorder

References

  • 1.

    WHO, Arsenic, Fact sheet, February, 2018. Available at: https://www.who.int/news-room/fact-sheets/detail/arsenic.

  • 2.

    Ravenscroft P, Brammer H, Richards K. Arsenic pollution: a global synthesis. Chicester, UK: John Wiley & Sons; 2008:28.Google Scholar

  • 3.

    Flanagan SV, Johnston RB, Zheng Y. Arsenic in tube well water in Bangladesh: health and economic impacts and implications for arsenic mitigation. Bull World Health Organ 2009;90(11):839–46.Google Scholar

  • 4.

    Brinkel J, Khan MH, Kraemer A. A systematic review of arsenic exposure and its social and mental health effects with special reference to Bangladesh. Int J Environ Res Public Health 2009;6(5):1609–19.CrossrefPubMedGoogle Scholar

  • 5.

    Rodriguez VM, Jimenez-Capdeville ME, Giordano M. The effects of arsenic exposure on the nervous system. Toxicol Lett 2003;145(1):1–18.PubMedCrossrefGoogle Scholar

  • 6.

    Gharibzadeh S, Hoseini SS. Arsenic exposure may be a risk factor for Alzheimer’s disease. J Neuropsychiatry Clinical Neurosci 2008;20(4):501.CrossrefGoogle Scholar

  • 7.

    Fujino Y, Guo X, Liu J, You L, Miyatake M, Yoshimura T, et al. Mental health burden amongst inhabitants of an arsenic-affected area in Inner Mongolia, China. Soc Sci Med 2004;59(9):1969–73.PubMedCrossrefGoogle Scholar

  • 8.

    Gerr F, Letz R, Ryan PB, Green RC. Neurological effects of environmental exposure to arsenic in dust and soil among humans. Neurotoxicology 2000;21(4):475–87.PubMedGoogle Scholar

  • 9.

    Mazumder DG, Ghosh A, Majumdar KK, Ghosh N, Saha C, Mazumder RG. Arsenic contamination of ground water and its health impact on population of district of Nadia, West Bengal, India. Indian J Community Med 2010;35:331–8.CrossrefPubMedGoogle Scholar

  • 10.

    Le Quesne PM, McLeod JG. Peripheral neuropathy following a single exposure to arsenic: clinical course in four patients with electrophysiological and histological studies. J Neurol Sci 1977;32(3):437–51.CrossrefGoogle Scholar

  • 11.

    Hafeman DM, Ahsan H, Louis ED, Siddique AB, Slavkovich V, Cheng Z, et al. Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh. J Occup Environ Med 2005;47(8):778–84.CrossrefGoogle Scholar

  • 12.

    Liu J, Gao Y, Liu H, Sun J, Liu Y, Wu J, et al. Assessment of relationship on excess arsenic intake from drinking water and cognitive impairment in adults and elders in arsenicosis areas. Int J Hyg Environ Health 2017;220(2 Pt B):424–30.PubMedCrossrefGoogle Scholar

  • 13.

    Escudero-Lourdes C. Toxicity mechanisms of arsenic that are shared with neurodegenerative diseases and cognitive impairment: role of oxidative stress and inflammatory responses. Neurotoxicology 2016;53:223–35.PubMedCrossrefGoogle Scholar

  • 14.

    Chowdhury S, Krause-Pilatus A, Zimmermann KF. Arsenic contamination of drinking water and mental health. DEF-Discussion Papers on Development Policy No. 222; 2016. Available at: http://dx.doi.org/10.2139/ssrn.2811583.

  • 15.

    Carroll CR, Noonan C, Garroutte EM, Navas-Acien A, Verney SP, Buchwald D. Low-level inorganic arsenic exposure and neuropsychological functioning in American Indian elders. Environ Res 2017;156:74–9.CrossrefPubMedGoogle Scholar

  • 16.

    Ishii K, Tamaoka A. Ten-years records of organic arsenic (diphenyl arsinic acid) poisoning: epidemiology, clinical feature, metabolism, and toxicity. Brain Nerve 2015;67:5–18.Google Scholar

  • 17.

    Blom S, Lagerkvist B, Linderholm H. Arsenic exposure to smelter workers. Clinical and neurophysiological studies. Scand J Work Environ Health 1985;11:265–9.CrossrefPubMedGoogle Scholar

  • 18.

    Lagerkvist BJ, Zetterlund B. Assessment of exposure to arsenic among smelter workers: a five year follow up. Am J Ind Med 1994;25(4):477–88.PubMedCrossrefGoogle Scholar

  • 19.

    Sińczuk-Walczak H, Szymczak M, Halatek T. Effects of occupational exposure to arsenic on the nervous system: clinical and neurophysiological studies. Int J Occup Med Environ Health 2010;23(4):347–55.PubMedGoogle Scholar

  • 20.

    Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, van Geen A, et al. Water arsenic exposure and children’s intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004;112:1329–33.PubMedCrossrefGoogle Scholar

  • 21.

    Tseng HP, Wang YH, Wu MM, The HW, Chiou HY, Chen CJ. Association between chronic exposure to arsenic and slow nerve conduction velocity among adolescents in Taiwan. J Health Popul Nutr 2006;24:182–9.PubMedGoogle Scholar

  • 22.

    Wright RO, Amarasiriwardena C, Woolf AD, Jim R, Bellinger DC. Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site. Neurotoxicology 2006;27(2):210–6.CrossrefGoogle Scholar

  • 23.

    Tsai SY, Chou HY, Chen CM, Chen CJ. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 2003;24(4–5):747–53.CrossrefPubMedGoogle Scholar

  • 24.

    Tsuji Joyce S, Garry Michael R, Perez V, Chang Ellen T. Low-level arsenic exposure and developmental neurotoxicity in children: a systematic review and risk assessment. Toxicology 2015;337:91–107.CrossrefPubMedGoogle Scholar

  • 25.

    Tolins M, Ruchirawat M, Landrigan P. The developmental neurotoxicity of arsenic: cognitive and behavioral consequences of early life exposure. Ann Glob Health 2014;80(4):303–14.CrossrefPubMedGoogle Scholar

  • 26.

    Von Ehrenstein OS, Poddar S, Yuan Y, Mazumder DG, Eskenazi B, Basu A, et al. Children’s intellectual function in relation to arsenic exposure. Epidemiology 2007;18:44–51.CrossrefPubMedGoogle Scholar

  • 27.

    Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline J, et al. Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh. Environ Health Perspect 2007;115:285–9.CrossrefPubMedGoogle Scholar

  • 28.

    Siripitayakunkit U, Visudhiphan P, Pradipasen M, Vorapongsathron T. Association between chronic arsenic exposure and children’s intelligence in Thailand. In Proc. of the third International conference on Arsenic exposure and health effects, July 12–15, 1998, San Diego, CA, USA. Amsterdam: Elsevier Science Ltd, 1999:141–9.Google Scholar

  • 29.

    Hamadani JD, Tofail F, Nermell B, Gardner R, Shiraji S, Bottai M, et al. Critical windows of exposure for arsenic-associated impairment of cognitive function in pre-school girls and boys: a population-based cohort study. Int J Epidemiol 2011;40(6):1593–604.CrossrefGoogle Scholar

  • 30.

    Calderón J, Navarro ME, Jimenez-Capdeville ME, Santos-Diaz MA, Golden A, Rodriguez-Leyva I, et al. Exposure to arsenic and lead and neuropsychological development in Mexican children. Environ Res 2001;85(2):69–76.CrossrefPubMedGoogle Scholar

  • 31.

    Rosado JL, Dolores R, Katarzyna K, Olga R, Javier Al, Patricia L, et al. Arsenic exposure and cognitive performance in Mexican schoolchildren. Environ Health Perspect 2007;115(9):1371–5.PubMedCrossrefGoogle Scholar

  • 32.

    Wang SX, Wang ZH, Cheng XT, Li J, Sang ZP, Zhang XD, et al. Arsenic and fluoride exposure in drinking water: children’s IQ and growth in Shanyin county, Shanxi province, China. Environ Health Perspect 2007;115:643–7.PubMedCrossrefGoogle Scholar

  • 33.

    Wai KM, Ser PH, Ahmad SA, Yasmin R, Ito Y, Konishi S, et al. In-utero arsenic exposure and growth of infants from birth to 6 months of age: a prospective cohort study in rural Bangladesh. Int J Environ Health Res 2019;29:1–14.Google Scholar

  • 34.

    Wang B, Liu J, Liu B, Liu X, Yu X. Prenatal exposure to arsenic and neurobehavioral development of newborns in China. Environ Int 2018;121(Pt 1):421–7.PubMedCrossrefGoogle Scholar

  • 35.

    Ishii N, Mochizuki H, Ebihara Y, Shiomi K, Nakazato M. Clinical symptoms, neurological signs, and electrophysiological findings in surviving residents with probable arsenic exposure in Toroku, Japan. Arch Environ Contam Toxicol 2018;75(4):521–9.CrossrefPubMedGoogle Scholar

  • 36.

    Freire C, Amaya E, Gil F, Fernández MF, Murcia M, Llop S, et al. Prenatal co-exposure to neurotoxic metals and neurodevelopment in preschool children: the Environment and Childhood (INMA) Project. Sci Total Environ 2018;621: 340–51.PubMedCrossrefGoogle Scholar

  • 37.

    Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Ahsan H, Levy D, et al. Arsenic and manganese exposure and children’s intellectual function. Neurotoxicology 2011;32(4):450–7.PubMedCrossrefGoogle Scholar

  • 38.

    Wasserman GA, Liu X, Parvez F, Chen Y, Factor-Litvak P, LoIacono NJ, et al. A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. Environ Int 2018;118:304–13.CrossrefPubMedGoogle Scholar

  • 39.

    Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, García-Villarino M, Fernández-Somoano A, et al. Inorganic arsenic exposure and neuropsychological development of children of 4–5 years of age living in Spain. Environ Res 2019;174:135–42.PubMedCrossrefGoogle Scholar

  • 40.

    Aung KH, Kyi-Tha-Thu C, Sano K, Nakamura K, Tanoue A, Nohara K, et al. Prenatal exposure to arsenic impairs behavioral flexibility and cortical structure in mice. Front Neurosci 2016;10:137.PubMedGoogle Scholar

  • 41.

    Luo JH, Qiu ZQ, Shu WQ, Zhang YY, Zhang L, Chen JA. Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats. Toxicol Lett 2009;184(2):121–5.PubMedCrossrefGoogle Scholar

  • 42.

    Gandhi DN, Kumar R. Arsenic toxicity and neurobehaviors: a review. Innov Pharm Pharmacother 2013;1(1):1–15.Google Scholar

  • 43.

    Ramos-Chávez LA, Rendón-López CRR, Zepeda A, Adaya DS, Del Razo LM, Gonsebatt ME. Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment. Front Cell Neurosci 2015;9:21.PubMedGoogle Scholar

  • 44.

    Bashir S, Sharma Y, Irshad M, Gupta SD, Dogra TD. Arsenic-induced cell death in liver and brain of experimental rats. Basic Clin Pharmacol Toxicol 2006;98(1):38–43.PubMedCrossrefGoogle Scholar

  • 45.

    Wu C, Gu X, Ge Y, Zhang J, Wang J. Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats. Fluoride 2006;39(4):274–9.Google Scholar

  • 46.

    Haider SS, Najar MS. Arsenic induces oxidative stress, sphingolipidosis, depletes proteins and some antioxidants in various regions of rat brain. Kathmandu Univ Med J 2008;6(1):60–9.Google Scholar

  • 47.

    Mishra D, Flora SJS. Differential oxidative stress and DNA damage in rat brain regions and blood following chronic arsenic exposure. Toxicol Ind Health 2008;24(4):247–56.CrossrefPubMedGoogle Scholar

  • 48.

    Zarazúa S, Perez-Severiano F, Delgado JM, Martínez LM, Ortiz-Perez D, Jimenez-Capdeville ME. Decreased nitric oxide production in the rat brain after chronic arsenic exposure. Neuro Chem Res 2006;31(8):1069–77.Google Scholar

  • 49.

    Chattopadhyay S, Bhaumik S, Purkayastha M, Basu S, Chaudhuri AN, Gupta SD. Apoptosis and necrosis in developing brain cells due to arsenic toxicity and protection with antioxidants. Toxicol Lett 2002;136(1):65–76.CrossrefPubMedGoogle Scholar

  • 50.

    Sharma A, Kshetrimayum C, Sadhu HG, Kumar S. Arsenic-induced oxidative stress, cholinesterase activity in the brain of Swiss albino mice, and its amelioration by antioxidants Vitamin E and Coenzyme Q10. Environ Sci Pollut Res Int 2018;25(24):23946–53.CrossrefPubMedGoogle Scholar

  • 51.

    Zhou H, Zhao W, Ye L, Chen Z, Cui Y. Postnatal low-concentration arsenic exposure induces autism-like behavior and affects frontal cortex neurogenesis in rats. Environ Toxicol Pharmacol 2018;62:188–98.CrossrefPubMedGoogle Scholar

  • 52.

    Manthari RK, Tikka C, Ommati MM, Niu R, Sun Z, Wang J, et al. Arsenic-induced autophagy in the developing mouse cerebellum: involvement of the blood-brain barrier’s tight-junction proteins and the PI3K-Akt-mTOR signaling pathway. J Agric Food Chem 2018;66(32):8602–14.CrossrefPubMedGoogle Scholar

  • 53.

    Htway SM, Sein MT, Nohara K, Win-Shwe TT. Effects of developmental arsenic rxposure on the social behavior and related gene expression in C3H adult male mice. Int J Environ Res Public Health 2019;16(2):174.CrossrefGoogle Scholar

  • 54.

    Tyler CR, Allan AM. The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: a review. Curr Environ Health Rep 2014;1:132.CrossrefPubMedGoogle Scholar

  • 55.

    Mochizuki H, Phyu KP, Aung MN, Zin PW, Yano Y, Myint MZ, et al. Peripheral neuropathy induced by drinking water contaminated with low-dose arsenic in Myanmar. Environ Health Prev Med 2019;24(1):23.PubMedCrossrefGoogle Scholar

  • 56.

    Masuda T, Ishii K, Seto Y, Hosoya T, Tanaka R, Nakayama T, et al. Long-term accumulation of diphenylarsinic acid in the central nervous system of Cynomolgus monkeys. Arch Toxicol 2017;91(8):2799–812.PubMedCrossrefGoogle Scholar

  • 57.

    Bolla-Wilson K, Bleecker ML. Neuropsychological impairment following inorganic arsenic exposure. J Occup Med 1987;29(6):500–3.PubMedGoogle Scholar

  • 58.

    Parvez F, Wasserman GA, Factor-Litvak P, Liu X, Slavkovich V, Siddique AB, et al. Arsenic exposure and motor function among children in Bangladesh. Environ Health Perspect 2011;119(11):1665–70.PubMedCrossrefGoogle Scholar

  • 59.

    Hamadani JD, Grantham-McGregor SM, Tofail F, Nermell B, Fängström B, Huda SN, et al. Pre- and postnatal arsenic exposure and child development at 18 months of age: a cohort study in rural Bangladesh. Int J Epidemiol 2010;39(5):1206–16.CrossrefPubMedGoogle Scholar

  • 60.

    Davey JC, Bodwell JE, Gosse JA, Hamilton JW. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor–mediated gene expression in vivo and in cell culture. Toxicol Sci 2007;98(1):75–86.CrossrefPubMedGoogle Scholar

  • 61.

    Gosse JA, Taylor VF, Jackson BP, Hamilton JW, Bodwell JE. Monomethylated trivalent arsenic species disrupt steroid receptor interactions with their DNA response elements at non-cytotoxic cellular concentrations. J Appl Toxicol 2014;34(5):498–505.PubMedCrossrefGoogle Scholar

  • 62.

    Schug TT, Ashley MB, Kimberly G, Jerrold JH, Cindy PL. Elucidating the links between endocrine disruptors and neuro development. Endocrinology 2015;156(6):1941–51.CrossrefGoogle Scholar

  • 63.

    Shiue I. Urinary arsenic, pesticides, heavy metals, phthalates, polyaromatic hydrocarbons, and polyfluoroalkyl compounds are associated with sleep troubles in adults: USA NHANES, 2005–2006. Environ Sci Pollut Res Int 2017;24(3):3108–16.CrossrefPubMedGoogle Scholar

  • 64.

    Syed EH, Poudel KC, Kayako S, Junko Y, Habibul A, Masamine J. Quality of life and mental health status of arsenic-affected patients in a Bangladeshi population. J Health Popul Nutr 2012;30(3):262–9.Google Scholar

  • 65.

    Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Kline J, Siddique AB, et al. Child intelligence and reductions in water arsenic and manganese: a two-year follow-up study in Bangladesh. Environ Health Perspect 2015;124(7):1114–20.PubMedGoogle Scholar

About the article

Corresponding author: Dr. Sunil Kumar, MSc, PhD, A-10 Radhey Kunj Apartment, Shahibaug, Ahmedabad 380004, India, Phone: 91-079-22864939, Mobile: 09426395738; and Former Director-in-Charge, National Institute of Occupational Health (ICMR), Ahmedabad 380016, India, E-mail: agarwalsk1955@gmail.com


Received: 2019-07-03

Accepted: 2019-09-09

Published Online: 2019-10-11

Published in Print: 2019-12-18


Research funding: No funding was received for compilation of this MS.

Conflict of interest: No conflict of interest.

Informed consent: Not applicable.

Ethical approval: The study does not require ethical approval.


Citation Information: Reviews on Environmental Health, Volume 34, Issue 4, Pages 403–414, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: https://doi.org/10.1515/reveh-2019-0052.

Export Citation

©2019 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Comments (0)

Please log in or register to comment.
Log in