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Reviews on Environmental Health

Editor-in-Chief: Carpenter, David O. / Sly, Peter

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Volume 34, Issue 4


Arsenic exposure with reference to neurological impairment: an overview

Anupama Sharma / Sunil Kumar
  • Corresponding author
  • A-10 Radhey Kunj Apartment, Shahibaug, Ahmedabad 380004, India
  • Former Director-in-Charge, National Institute of Occupational Health (ICMR), Ahmedabad 380016, India
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-10-11 | DOI: https://doi.org/10.1515/reveh-2019-0052


Arsenic (As) toxicity has become a public health and environmental problem, which is a serious issue in certain parts of the world. Many people are exposed to As through contaminated drinking water, food and soil, through occupation, etc. Chronic As exposure is linked to various hostile health effects including skin problems, cancer, diabetes, cardiovascular disease, reproductive and developmental and neurological problems in exposed subjects. Experimental existing data indicate that chronic As exposure affects the nervous system by impairing the nerve and brain tissues of the exposed animals, and clinical studies indicate that As exposure leads to both central nervous system and peripheral nervous system impairments and also causes depression, memory impairment and difficulty in problem solving, affects body coordination, etc. Various prenatal and postnatal studies with respect to As exposure also suggest that developing offspring and young children are susceptible to As exposure. The only solution to this serious health problem is to stop occupational As exposure and provide As free drinking water to the affected population.

Keywords: arsenic; central nervous system; cognitive; coordination; memory impairments; neurological disorder


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About the article

Corresponding author: Dr. Sunil Kumar, MSc, PhD, A-10 Radhey Kunj Apartment, Shahibaug, Ahmedabad 380004, India, Phone: 91-079-22864939, Mobile: 09426395738; and Former Director-in-Charge, National Institute of Occupational Health (ICMR), Ahmedabad 380016, India, E-mail: agarwalsk1955@gmail.com

Received: 2019-07-03

Accepted: 2019-09-09

Published Online: 2019-10-11

Published in Print: 2019-12-18

Research funding: No funding was received for compilation of this MS.

Conflict of interest: No conflict of interest.

Informed consent: Not applicable.

Ethical approval: The study does not require ethical approval.

Citation Information: Reviews on Environmental Health, Volume 34, Issue 4, Pages 403–414, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: https://doi.org/10.1515/reveh-2019-0052.

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