Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John


IMPACT FACTOR 2017: 2.590
5-year IMPACT FACTOR: 3.078

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 0.980
Source Normalized Impact per Paper (SNIP) 2017: 0.804

Online
ISSN
2191-0200
See all formats and pricing
More options …
Volume 22, Issue 3

Issues

Allosteric modulation of ATP-gated P2X receptor channels

Claudio Coddou
  • Section on Cellular Signaling, Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4510, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stanko S. Stojilkovic
  • Section on Cellular Signaling, Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4510, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ J. Pablo Huidobro-Toro
  • Centro de Envejecimiento y Regeneración, CARE, Centro Regulación Celular y Patología Prof. J.V. Luco, Instituto Milenio de Biología Fundamental y Aplicada, MIFAB, Departamento de Fisiología, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-03-16 | DOI: https://doi.org/10.1515/rns.2011.014

Abstract

Seven mammalian purinergic receptor subunits, denoted P2X1–P2X7, and several spliced forms of these subunits have been cloned. When heterologously expressed, these cDNAs encode ATP-gated non-selective cation channels organized as trimers. All activated receptors produce cell depolarization and promote Ca2+ influx through their pores and indirectly by activating voltage-gated calcium channels. However, the biophysical and pharmacological properties of these receptors differ considerably, and the majority of these subunits are also capable of forming heterotrimers with other members of the P2X receptor family, which confers further different properties. These channels have three ATP binding domains, presumably located between neighboring subunits, and occupancy of at least two binding sites is needed for their activation. In addition to the orthosteric binding sites for ATP, these receptors have additional allosteric sites that modulate the agonist action at receptors, including sites for trace metals, protons, neurosteroids, reactive oxygen species and phosphoinositides. The allosteric regulation of P2X receptors is frequently receptor-specific and could be a useful tool to identify P2X members in native tissues and their roles in signaling. The focus of this review is on common and receptor-specific allosteric modulation of P2X receptors and the molecular base accounting for allosteric binding sites.

Keywords: alcohol; allosterism; copper; neurosteroids; phosphoinositides; purinergic receptor channels; reactive oxygen species; zinc

About the article

Corresponding author


Published Online: 2011-03-16

Published in Print: 2011-06-01


Citation Information: Reviews in the Neurosciences, Volume 22, Issue 3, Pages 335–354, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/rns.2011.014.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Bin Li, Jin Wang, Xiaoyang Cheng, Yan Liu, Yang Yang, Xiaona Yang, Changrun Guo, Youya Niu, Peng Cao, Xiangyang Lu, Michael X. Zhu, Yun Tian, and Ye Yu
Science Bulletin, 2018
[2]
Claudio Coddou, Rodrigo Sandoval, María José Hevia, and Stanko S. Stojilkovic
Neuroscience Letters, 2018
[3]
M. Verónica Donoso, Felipe Hernández, Tania Villalón, Claudio Acuña-Castillo, and J. Pablo Huidobro-Toro
Purinergic Signalling, 2018, Volume 14, Number 2, Page 121
[4]
Jin Wang, Yao Wang, Wen-Wen Cui, Yichen Huang, Yang Yang, Yan Liu, Wen-Shan Zhao, Xiao-Yang Cheng, Wang-Sheng Sun, Peng Cao, Michael X. Zhu, Rui Wang, Motoyuki Hattori, and Ye Yu
Proceedings of the National Academy of Sciences, 2018, Page 201800907
[5]
Carolina Paredes, Shuo Li, Xiaoli Chen, and Claudio Coddou
FEBS Open Bio, 2018
[6]
Claudio Coddou, Zonghe Yan, and Stanko S. Stojilkovic
American Journal of Physiology-Cell Physiology, 2015, Volume 308, Number 9, Page C729
[7]
Daniela Gentile, Pietro E. Lazzerini, Alessandra Gamberucci, Mariarita Natale, Enrico Selvi, Francesca Vanni, Alessandra Alì, Paolo Taddeucci, Silvia Del-Ry, Manuela Cabiati, Veronica Della-Latta, David J. Abraham, Maria A. Morales, Rosella Fulceri, Franco Laghi-Pasini, and Pier L. Capecchi
Frontiers in Pharmacology, 2017, Volume 8
[8]
Sukanya Punthambaker, Jacob A. Blum, and Richard I. Hume
Journal of Biological Chemistry, 2012, Volume 287, Number 26, Page 22099
[10]
Shu Xing, Matthew W. Grol, Peter H. Grutter, S. Jeffrey Dixon, and Svetlana V. Komarova
Frontiers in Physiology, 2016, Volume 7
[11]
Francisco Peralta and Juan Huidobro-Toro
International Journal of Molecular Sciences, 2016, Volume 17, Number 7, Page 1059
[12]
Eric Pollatzek, Norma Hitzel, Daniela Ott, Katrin Raisl, Bärbel Reuter, and Rüdiger Gerstberger
Neuroscience, 2016, Volume 327, Page 95
[13]
Kenneth A. Jacobson and Christa E. Müller
Neuropharmacology, 2016, Volume 104, Page 31
[14]
GEDD Moura, SV Lucena, MA Lima, FD Nascimento, TF Gesteira, HB Nader, EJ Paredes-Gamero, and ILS Tersariol
Cell Death Discovery, 2015, Volume 1, Page 15005
[15]
G E D D Moura, S V Lucena, M A Lima, F D Nascimento, T F Gesteira, H B Nader, E J Paredes-Gamero, and I L S Tersariol
Cell Death and Disease, 2015, Volume 6, Number 11, Page e1997
[16]
Pablo Galaz, Rafael Barra, Hector Figueroa, and Trinidad Mariqueo
Pharmacological Research, 2015, Volume 101, Page 65
[17]
Chloé Habermacher, Kate Dunning, Thierry Chataigneau, and Thomas Grutter
Neuropharmacology, 2016, Volume 104, Page 18
[18]
Ji Xu, Hua Chai, Konstantin Ehinger, Terrance M. Egan, Rahul Srinivasan, Manfred Frick, and Baljit S. Khakh
The Journal of General Physiology, 2014, Volume 144, Number 1, Page 81
[20]
Wenjun Zhu, Crystal Acosta, Brian MacNeil, Claudia Cortes, Howard Intrater, Yuewen Gong, and Mike Namaka
BioMed Research International, 2013, Volume 2013, Page 1
[21]
Karina Kaczmarek-Hájek, Éva Lörinczi, Ralf Hausmann, and Annette Nicke
Purinergic Signalling, 2012, Volume 8, Number 3, Page 375

Comments (0)

Please log in or register to comment.
Log in