Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

8 Issues per year


IMPACT FACTOR 2016: 2.546
5-year IMPACT FACTOR: 3.191

CiteScore 2016: 3.30

SCImago Journal Rank (SJR) 2015: 1.605
Source Normalized Impact per Paper (SNIP) 2015: 0.912

Online
ISSN
2191-0200
See all formats and pricing
In This Section
Volume 22, Issue 4 (Aug 2011)

Issues

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

Cristina Marchetti
  • Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, I-00143 Rome, Italy
/ Hélène Marie
  • Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, I-00143 Rome, Italy
  • Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), UMR6097 CNRS/UNSA, F-06560 Valbonne, France
  • Email:
Published Online: 2011-07-06 | DOI: https://doi.org/10.1515/rns.2011.035

Abstract

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) are used to investigate mechanisms underlying disease pathology and identify therapeutic strategies. Most Tg AD models, which at least partly recapitulate the AD phenotype, are based on insertion of one or more human mutations (identified in Familial AD) into the mouse genome, with the notable exception of the anti-NGF mouse, which is based on the cholinergic unbalance hypothesis. It has recently emerged that impaired hippocampal synaptic function is an early detectable pathological alteration, well before the advanced stage of amyloid plaque accumulation and general cell death. Nevertheless, electrophysiological studies performed on different Tg models or on the same model by different research groups have yielded contrasting results. We therefore summarized data from original research papers studying hippocampal synaptic function using electrophysiology, to review what we have learned so far. We analyzed results obtained using the following Tg models: (1) single/multiple APP mutations; (2) single presenilin (PS) mutations; (3) APPxPS1 mutations; (4) APPxPS1xtau mutations (3xTg); and (5) anti-NGF expressing (AD11) mice. We observed that the majority of papers focus on excitatory basic transmission and long-term potentiation, while few studies evaluate inhibitory transmission and long-term depression. We searched for common synaptic alterations in the various models that might underlie the memory deficits observed in these mice. We also considered experimental variables that could explain differences in the reported results and briefly discuss successful rescue strategies. These analyses should prove useful for future design of electrophysiology experiments to assess hippocampal function in AD mouse models.

Keywords: Alzheimer’s disease; hippocampus; synaptic plasticity; transgenic mouse

About the article

Corresponding author


Received: 2011-03-25

Accepted: 2011-04-15

Published Online: 2011-07-06

Published Online: 2011-07-06

Published in Print: 2011-08-01



Citation Information: Reviews in the Neurosciences, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/rns.2011.035. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Liting Jiang, Meng Huang, Shujun Xu, Yu Wang, Pengyuan An, Chenxi Feng, Xiaowei Chen, Xiaofei Wei, Yifan Han, and Qinwen Wang
Molecular Neurobiology, 2015
[2]
Andreas Müller-Schiffmann, Arne Herring, Laila Abdel-Hafiz, Aisa N. Chepkova, Sandra Schäble, Diana Wedel, Anselm H. C. Horn, Heinrich Sticht, Maria A. de Souza Silva, Kurt Gottmann, Olga A. Sergeeva, Joseph P. Huston, Kathy Keyvani, and Carsten Korth
Brain, 2015, Page awv355
[3]
Davide Tampellini
Frontiers in Neuroscience, 2015, Volume 9
[4]
Bai Lu, Guhan Nagappan, Xiaoming Guan, Pradeep J. Nathan, and Paul Wren
Nature Reviews Neuroscience, 2013, Volume 14, Number 6, Page 401
[5]
David J. Koss, Benjamin D. Drever, Sandra Stoppelkamp, Gernot Riedel, and Bettina Platt
Cellular and Molecular Life Sciences, 2013, Volume 70, Number 14, Page 2585
[6]
Robert Nisticò, Marco Pignatelli, Sonia Piccinin, Nicola B. Mercuri, and Graham Collingridge
Molecular Neurobiology, 2012, Volume 46, Number 3, Page 572
[7]
Leslie M Tong, Helen Fong, and Yadong Huang
Experimental & Molecular Medicine, 2015, Volume 47, Number 3, Page e151
[8]
Marlene J Végh, Céline M Heldring, Willem Kamphuis, Sara Hijazi, Arie J Timmerman, Ka Li, Pim van Nierop, Huibert D Mansvelder, Elly M Hol, August B Smit, and Ronald E van Kesteren
Acta Neuropathologica Communications, 2014, Volume 2, Number 1, Page 76
[9]
Andrea Marcantoni, Elisabeth F. Raymond, Emilio Carbone, and Hélène Marie
Pflügers Archiv - European Journal of Physiology, 2014, Volume 466, Number 7, Page 1437
[10]
Ilya Chumakov, Serguei Nabirotchkin, Nathalie Cholet, Aude Milet, Aurélie Boucard, Damien Toulorge, Yannick Pereira, Esther Graudens, Sory Traoré, Julie Foucquier, Mickael Guedj, Emmanuel Vial, Noëlle Callizot, Rémy Steinschneider, Tangui Maurice, Viviane Bertrand, Catherine Scart-Grès, Rodolphe Hajj, and Daniel Cohen
Scientific Reports, 2015, Volume 5, Page 7608
[11]
Dmitry Ovchinnikov and Ernst Wolvetang
Journal of Clinical Medicine, 2014, Volume 3, Number 4, Page 1357
[12]
Zhifang Dong, Huili Han, Hongjie Li, Yanrui Bai, Wei Wang, Man Tu, Yan Peng, Limin Zhou, Wenting He, Xiaobin Wu, Tao Tan, Mingjing Liu, Xiaoyan Wu, Weihui Zhou, Wuyang Jin, Shu Zhang, Todd Charlton Sacktor, Tingyu Li, Weihong Song, and Yu Tian Wang
Journal of Clinical Investigation, 2015, Volume 125, Number 1, Page 234
[14]
Christian Czech and Fiona Grueninger
Drug Discovery Today: Therapeutic Strategies, 2013, Volume 10, Number 2, Page e73
[15]
Y. Buskila, S.E. Crowe, and G.C.R. Ellis-Davies
Neuroscience, 2013, Volume 254, Page 152
[16]
R. Nistico, F. Mori, M. Feligioni, F. Nicoletti, and D. Centonze
Philosophical Transactions of the Royal Society B: Biological Sciences, 2013, Volume 369, Number 1633, Page 20130162
[17]
Yadong Huang and Lennart Mucke
Cell, 2012, Volume 148, Number 6, Page 1204

Comments (0)

Please log in or register to comment.
Log in