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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

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IMPACT FACTOR 2016: 2.546
5-year IMPACT FACTOR: 3.191

CiteScore 2016: 3.30

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Source Normalized Impact per Paper (SNIP) 2016: 0.983

Online
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2191-0200
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Volume 23, Issue 2

Issues

Role of stem cells in the regeneration and repair of peripheral nerves

Zhiwu Ren
  • Key Laboratory of People Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China
  • Medical College of Nankai University, No. 94 Weijin Road, Nankai District, Tianjin 300071, People’s Republic of China
  • Other articles by this author:
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/ Yu Wang
  • Key Laboratory of People Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China
  • Other articles by this author:
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/ Jiang Peng
  • Key Laboratory of People Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China
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/ Qing Zhao
  • Key Laboratory of People Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China
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/ Shibi Lu
  • Key Laboratory of People Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China
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Published Online: 2012-01-26 | DOI: https://doi.org/10.1515/revneuro-2011-0069

Abstract

Peripheral nerve regeneration is a complex process, with Wallerian degeneration the most elementary reaction and Schwann cells playing an important role. In recent years, stem cells have been widely used to repair injured peripheral nerves. The sources of these stem cells are widespread and their effectiveness in the treatment of peripheral nerve injury may lie in their ability to differentiate into Schwann cells, secrete neurotrophic factors, and assist in myelin formation. Stem cells have been used as seed cells in tissue-engineered nerve grafts. The understanding of stem cell homing, novel repair material, and the ability to mobilize endogenous stem cells to assist peripheral nerve regeneration constitute a research direction of great interest.

Keywords: homing; peripheral nerve; regeneration; stem cell; tissue engineering

About the article

Corresponding author


Received: 2011-11-10

Accepted: 2011-12-12

Published Online: 2012-01-26

Published in Print: 2012-04-01


Citation Information: Reviews in the Neurosciences, Volume 23, Issue 2, Pages 135–143, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2011-0069.

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