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Reviews in the Neurosciences

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Neurologic and motor dysfunctions in APP transgenic mice

Robert Lalonde
  • Faculté des Sciences, Département de Psychologie, Laboratoire ICONES, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France
  • :
/ Ken-ichiro Fukuchi
  • Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, P.O. Box 1649, Peoria, IL 61656, USA
/ Catherine Strazielle
  • Faculté de Médecine, Laboratoire de Nutrition-Génétique et Exposition aux Risques Environnementaux, Université de Lorraine, INSERM U954, Service de Microscopie Electronique, 54500 Vandoeuvre-les-Nancy, France
Published Online: 2012-07-29 | DOI: https://doi.org/10.1515/revneuro-2012-0041

Abstract

The discovery of gene mutations underlying autosomal dominant Alzheimer’s disease has enabled researchers to reproduce several hallmarks of this disorder in transgenic mice, notably the formation of Aβ plaques in brain and cognitive deficits. APP transgenic mutants have also been investigated with respect to survival rates, neurologic functions, and motor coordination, which are all susceptible to alteration in Alzheimer dementia. Several transgenic lines expressing human mutated or wild-type APP had higher mortality rates than non-transgenic controls with or without the presence of Aβ plaques. Mortality rates were also elevated in APP transgenic mice with vascular amyloid accumulation, thereby implicating cerebrovascular factors in the precocious death observed in all APP transgenic models. In addition, myoclonic jumping has been described in APP mutants, together with seizure activity, abnormal limb-flexion and paw-clasping reflexes, and motor coordination deficits. The neurologic signs resemble the myoclonic movements, epileptic seizures, pathological reflexes, and gait problems observed in late-stage Alzheimer’s disease.

Keywords: Alzheimer’s disease; epilepsy; motor coordination; myoclonus; paw-clasping; premature death

Robert Lalonde

Prof. Robert Lalonde graduated from the University of Montreal, Department of Psychology, with a PhD degree in 1982. After postdoctoral training at the Clinical Research Institute of Montreal, he obtained a position as an Assistant Professor at the Department of Medicine at the University of Montreal. In 1996, he obtained a position as a Professor at the Department of Psychology at the University of Rouen. His main research work concerns the behavioral characterization of mutant mice as well as psychopharmacological studies. He has published 214 research articles.

Ken-ichiro Fukuchi

Dr. Ken-ichiro (Ken) Fukuchi graduated from the Osaka University Medical School with a Medical Degree in 1979 and a PhD in 1985 in the field of medical genetics. He is a neuroscientist, molecular biologist and trained as a geriatrician who has dedicated his life to biomedical research. The Fukuchi Laboratory research has been focused on studying the molecular mechanisms underlying age-associated diseases such as Alzheimer’s disease and developing new preventive and therapeutic measures for over 20 years. Dr. Fukuchi is the Principal Investigator and recipient of numerous research grants from various resources including National Institutes of Health (NIH). Dr. Fukuchi has published over 70 scientific peer reviewed articles in this research area.

Catherine Strazielle

Dr. Catherine Strazielle graduated from the University of Lorraine with a MSc in Nutrition and a PhD in 1995 in Neuroscience, in the field of functional neuroanatomy. After postdoctoral training in Montreal in 1995, she began to collaborate with Robert Lalonde concerning the phenotypic characterization of animal models of human neurodegenerative diseases, particularly Alzheimer’s disease and cerebellar ataxia, evaluating by means of brain cartographies, the neurochemical changes linked to behavioral performances. She has published more than 60 articles in this field.

Corresponding author: Robert Lalonde, Faculté des Sciences, Département de Psychologie, Laboratoire ICONES, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France


Received: 2012-03-19

Accepted: 2012-05-02

Published Online: 2012-07-29

Published in Print: 2012-08-01


Citation Information: . Volume 23, Issue 4, Pages 363–379, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2012-0041, July 2012

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