Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

8 Issues per year

IMPACT FACTOR 2016: 2.546
5-year IMPACT FACTOR: 3.191

CiteScore 2016: 3.30

SCImago Journal Rank (SJR) 2016: 1.249
Source Normalized Impact per Paper (SNIP) 2016: 0.983

See all formats and pricing
More options …
Volume 23, Issue 4 (Aug 2012)


Neurologic and motor dysfunctions in APP transgenic mice

Robert Lalonde
  • Corresponding author
  • Faculté des Sciences, Département de Psychologie, Laboratoire ICONES, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ken-ichiro Fukuchi
  • Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, P.O. Box 1649, Peoria, IL 61656, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Catherine Strazielle
  • Faculté de Médecine, Laboratoire de Nutrition-Génétique et Exposition aux Risques Environnementaux, Université de Lorraine, INSERM U954, Service de Microscopie Electronique, 54500 Vandoeuvre-les-Nancy, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-07-29 | DOI: https://doi.org/10.1515/revneuro-2012-0041


The discovery of gene mutations underlying autosomal dominant Alzheimer’s disease has enabled researchers to reproduce several hallmarks of this disorder in transgenic mice, notably the formation of Aβ plaques in brain and cognitive deficits. APP transgenic mutants have also been investigated with respect to survival rates, neurologic functions, and motor coordination, which are all susceptible to alteration in Alzheimer dementia. Several transgenic lines expressing human mutated or wild-type APP had higher mortality rates than non-transgenic controls with or without the presence of Aβ plaques. Mortality rates were also elevated in APP transgenic mice with vascular amyloid accumulation, thereby implicating cerebrovascular factors in the precocious death observed in all APP transgenic models. In addition, myoclonic jumping has been described in APP mutants, together with seizure activity, abnormal limb-flexion and paw-clasping reflexes, and motor coordination deficits. The neurologic signs resemble the myoclonic movements, epileptic seizures, pathological reflexes, and gait problems observed in late-stage Alzheimer’s disease.

Keywords: Alzheimer’s disease; epilepsy; motor coordination; myoclonus; paw-clasping; premature death

About the article

Robert Lalonde

Prof. Robert Lalonde graduated from the University of Montreal, Department of Psychology, with a PhD degree in 1982. After postdoctoral training at the Clinical Research Institute of Montreal, he obtained a position as an Assistant Professor at the Department of Medicine at the University of Montreal. In 1996, he obtained a position as a Professor at the Department of Psychology at the University of Rouen. His main research work concerns the behavioral characterization of mutant mice as well as psychopharmacological studies. He has published 214 research articles.

Ken-ichiro Fukuchi

Dr. Ken-ichiro (Ken) Fukuchi graduated from the Osaka University Medical School with a Medical Degree in 1979 and a PhD in 1985 in the field of medical genetics. He is a neuroscientist, molecular biologist and trained as a geriatrician who has dedicated his life to biomedical research. The Fukuchi Laboratory research has been focused on studying the molecular mechanisms underlying age-associated diseases such as Alzheimer’s disease and developing new preventive and therapeutic measures for over 20 years. Dr. Fukuchi is the Principal Investigator and recipient of numerous research grants from various resources including National Institutes of Health (NIH). Dr. Fukuchi has published over 70 scientific peer reviewed articles in this research area.

Catherine Strazielle

Dr. Catherine Strazielle graduated from the University of Lorraine with a MSc in Nutrition and a PhD in 1995 in Neuroscience, in the field of functional neuroanatomy. After postdoctoral training in Montreal in 1995, she began to collaborate with Robert Lalonde concerning the phenotypic characterization of animal models of human neurodegenerative diseases, particularly Alzheimer’s disease and cerebellar ataxia, evaluating by means of brain cartographies, the neurochemical changes linked to behavioral performances. She has published more than 60 articles in this field.

Corresponding author: Robert Lalonde, Faculté des Sciences, Département de Psychologie, Laboratoire ICONES, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France

Received: 2012-03-19

Accepted: 2012-05-02

Published Online: 2012-07-29

Published in Print: 2012-08-01

Citation Information: , ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2012-0041.

Export Citation

©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

T.P. O’Leary, A. Robertson, P.H. Chipman, V.F. Rafuse, and R.E. Brown
Behavioural Brain Research, 2017
Antonia Nicole Klein, Tamar Ziehm, Thomas van Groen, Inga Kadish, Anne Elfgen, Markus Tusche, Maren Thomaier, Kerstin Reiss, Oleksandr Brener, Lothar Gremer, Janine Kutzsche, and Dieter Willbold
ACS Chemical Neuroscience, 2017
Lu Zhao, Sha Liu, Yin Wang, Qiaoyan Zhang, Wenjuan Zhao, Zejian Wang, Ming Yin, and Jaya Padmanabhan
PLOS ONE, 2015, Volume 10, Number 7, Page e0133289
Marie K. Bondulich, Tong Guo, Christopher Meehan, John Manion, Teresa Rodriguez Martin, Jacqueline C. Mitchell, Tibor Hortobagyi, Natalia Yankova, Virginie Stygelbout, Jean-Pierre Brion, Wendy Noble, and Diane P. Hanger
Brain, 2016, Volume 139, Number 8, Page 2290
Inga Kadish, Ashish Kumar, Ulrika Beitnere, Emily Jennings, William McGilberry, and Thomas van Groen
Experimental Gerontology, 2016, Volume 86, Page 39
Sung-Soo Jang, Sara E. Royston, Gunhee Lee, Shuwei Wang, and Hee Jung Chung
Neural Plasticity, 2016, Volume 2016, Page 1
Sung-Soo Jang and Hee Jung Chung
Neural Plasticity, 2016, Volume 2016, Page 1
Yajing Peng, Mi Jin Kim, Rikki Hullinger, Kenneth J. O’Riordan, Corinna Burger, Mariana Pehar, and Luigi Puglielli
Brain, 2016, Volume 139, Number 3, Page 937
Alexandra J. Mably, Wen Liu, Jessica M. Mc Donald, Jean-Cosme Dodart, Frédérique Bard, Cynthia A. Lemere, Brian O'Nuallain, and Dominic M. Walsh
Neurobiology of Disease, 2015, Volume 82, Page 372
Yun Li, Yahong Liu, Zhaojun Wang, and Yongjun Jiang
Expert Opinion on Biological Therapy, 2013, Volume 13, Number 11, Page 1515
Alexandra J. Mably, Daniel Kanmert, Jessica M. Mc Donald, Wen Liu, Barbara J. Caldarone, Cynthia A. Lemere, Brian O'Nuallain, Kenneth S. Kosik, and Dominic M. Walsh
Neurobiology of Aging, 2015, Volume 36, Number 3, Page 1316
R. Allemang-Grand, J. Scholz, J. Ellegood, L.S. Cahill, C. Laliberté, P.E. Fraser, S.A. Josselyn, J.G. Sled, and J.P. Lerch
Neurobiology of Aging, 2015, Volume 36, Number 2, Page 638
Estela Castilla-Ortega, Cristina Rosell-Valle, Eduardo Blanco, Carmen Pedraza, Jerold Chun, Fernando Rodríguez de Fonseca, Guillermo Estivill-Torrús, and Luis J. Santín
Neuroscience Research, 2013, Volume 77, Number 3, Page 170
F. Schneider, K. Baldauf, W. Wetzel, and K.G. Reymann
Physiology & Behavior, 2014, Volume 135, Page 25

Comments (0)

Please log in or register to comment.
Log in