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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

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2191-0200
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Volume 23, Issue 4 (Aug 2012)

Issues

Inducible pluripotent stem cells for the treatment of ischemic stroke: current status and problems

Yu Zhu
  • Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Shu Wan
  • Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ren-ya Zhan
  • Corresponding author
  • Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-06-24 | DOI: https://doi.org/10.1515/revneuro-2012-0042

Abstract

Despite dramatic advancements in medical and surgical care, effective clinical therapies for ischemic stroke are limited. Stem-cell transplantation has emerged as a potential therapeutic approach for cell replacement in ischemic brain injuries. Inducible pluripotent stem cells (iPSCs) have become an alternative cell source for transplantation. They possess efficient capacities for neural differentiation without ethical and immune-rejection concerns. Substantial function of iPSCs in pre-clinical models of ischemic brain injury has been observed. However, several problems remain regarding the treatment of ischemic stroke with iPSCs: tumorigenicity, poor iPSC derivation methods, and undefined delivery variables. With the development of iPSC research, safer and more effective strategies will be achieved for highly effective and tumor-free cell treatment of ischemic stroke.

Keywords: inducible pluripotent stem cell; ischemic stroke; neural differentiation; stem cell transplantation; tumorigenicity

About the article

Yu Zhu

Yu Zhu is a MD candidate at the Zhejiang University School of Medicine. He is engaged in clinical and research work in neurosurgery, especially in the treatment for cerebral vascular disease and cerebral tumor. His thesis work focused on stem cell therapies for ischemic stroke and etiology of cerebral glioma.

Shu Wan

Shu Wan, PhD, MD, is an Associate Professor at the Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University. He received his MD degree in 1997 and did his PhD at the Zhejiang University School of Medicine. From June 2004 to October 2005 he continued his clinical training and research as a visiting scholar at the University of Michigan (in Ann Arbor), USA. His present clinical practice and research work focuses on cerebral vascular disease.

Ren-ya Zhan

Prof. Ren-ya Zhan, PhD, MD, is the Director of the Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University. He graduated from Zhe jiang University School of Medicine and received a MD degree in 1983, he did his PhD in Kiel University, Germany in 1998–2002. He has been constantly engaged in both preclinical and clinical research of cerebral vascular disease, cerebral tumor and severe craniocerebral trauma. He also leads a series of research teams investigating endogenous neural stem cells’ applicatory potential for ischemic stroke and the role of liposome in formation of glioma.


Corresponding author: Ren-ya Zhan, Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China


Received: 2012-04-02

Accepted: 2012-05-04

Published Online: 2012-06-24

Published in Print: 2012-08-01


Citation Information: , ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2012-0042.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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