Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

8 Issues per year


IMPACT FACTOR 2016: 2.546
5-year IMPACT FACTOR: 3.191

CiteScore 2016: 3.30

SCImago Journal Rank (SJR) 2016: 1.249
Source Normalized Impact per Paper (SNIP) 2016: 0.983

Online
ISSN
2191-0200
See all formats and pricing
More options …
Volume 24, Issue 1 (Feb 2013)

Issues

Multiple sclerosis and glutamate excitotoxicity

Milos Kostic / Nikola Zivkovic / Ivana Stojanovic
Published Online: 2012-11-12 | DOI: https://doi.org/10.1515/revneuro-2012-0062

Abstract

The previous understanding of multiple sclerosis was solely related to neuroinflammation and its harmful effects; however, countless data indicate the importance of some inflammation-independent, neurodegenerative mechanisms associated with mitochondria malfunction, iron deposition and oxidative stress. Recently, it has been postulated that glutamate excitotoxicity, a phenomenon that takes place when an excessive amount of glutamate overactivates its cellular receptors and induces cell death, could be a missing link between inflammatory and neurodegenerative processes evident in multiple sclerosis. Glutamate is the major excitatory neurotransmitter of the central nervous system, which has been proven to have a central role in a complex communication network established between all residential brain cells, including neurons, astrocytes, oligodendrocytes and microglia. Thus, the disturbance of glutamate homeostasis could affect practically all physiological functions and interactions of brain cells, leading to heterogeneity of pathological events. The understanding of glutamate excitotoxicity as a valid mechanism of central nervous system damage in multiple sclerosis, requires the revision of the current knowledge about a source of elevated extracellular glutamate, glutamate receptor alterations, alterations of glutamate transporters and metabolizing enzymes, as well as molecular mechanism of excitotoxic damage.

Keywords: axonal degeneration; demyelination; glutamate metabolizing enzymes; glutamate receptors; glutamate transporters

About the article

Milos Kostic

Dr. Milos S. Kostic, currently a PhD student, is working as a teaching assistant at the Department of Immunology, Faculty of Medicine, University of Nis. His ongoing PhD thesis explores Th immunological profile of patients suffering from multiple sclerosis and its repercussion on neurodegenerative processes in the form of axonal degeneration. Major scientific interest is Th17 polarized environment in encephalic compartment and its association with glutamate excitotoxicity.

Nikola Zivkovic

Dr. Nikola D. Zivkovic is employed as a teaching assistant at the Department of Pathology, Faculty of Medicine, University of Nis. Currently a PhD student, engaged in research in the field of immunoproliferative diseases. His special interest is head and neck pathology with focus on disorders of immune system in this region.

Ivana Stojanovic

Prof. Dr. Ivana R. Stojanovic received a PhD in Biochemistry at University of Nis Faculty of Medicine on polyamine and nitric oxide metabolism interactions in seizures. The leader of the scientific subproject, exploring L-arginine metabolism and nitric oxide signalling in CNS inflammation and neurodegeneration. Her current scientific interests focus on the role of oxidative stress, nitrergicsignalling and excitotoxicity in multiple sclerosis pathogenetic mechanisms.


Corresponding author: Milos Kostic, Departement of Immunology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia


Received: 2012-08-02

Accepted: 2012-09-07

Published Online: 2012-11-12

Published in Print: 2013-02-01


Citation Information: Reviews in the Neurosciences, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2012-0062.

Export Citation

©2013 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Marianna Monfrini, Maddalena Ravasi, Daniele Maggioni, Elisabetta Donzelli, Giovanni Tredici, Guido Cavaletti, and Arianna Scuteri
Molecular and Cellular Neuroscience, 2017
[2]
Zi-Wei Wang, Li-Jun Yang, Ying-Xue Ding, Yan-Zhong Chang, and Hong Cui
Experimental and Therapeutic Medicine, 2016, Volume 12, Number 3, Page 1723
[3]
Frédéric Doussau, Jean-Luc Dupont, Dorine Neel, Aline Schneider, Bernard Poulain, and Jean Louis Bossu
Expert Opinion on Drug Discovery, 2017, Page 1
[4]
Robert van den Berg, Casper C. Hoogenraad, and Rogier Q. Hintzen
Acta Neuropathologica, 2017, Volume 134, Number 1, Page 1
[5]
Cecilia Rajda, Dániel Pukoli, Zsuzsanna Bende, Zsófia Majláth, and László Vécsei
International Journal of Molecular Sciences, 2017, Volume 18, Number 2, Page 353
[6]
Ted M. Dawson and Valina L. Dawson
Annual Review of Pharmacology and Toxicology, 2017, Volume 57, Number 1, Page 437
[8]
Egle Cekanaviciute and Marion S. Buckwalter
Neurotherapeutics, 2016, Volume 13, Number 4, Page 685
[9]
Pia Crone Christensen, Zahra Samadi-Bahrami, Vlady Pavlov, Peter K. Stys, and G.R. Wayne Moore
Neuroscience Letters, 2016, Volume 630, Page 1
[10]
Lei Yang, Dewei Tan, and Hua Piao
Neurochemical Research, 2016, Volume 41, Number 8, Page 1845
[11]
Pablo Villoslada
Multiple Sclerosis and Demyelinating Disorders, 2016, Volume 1, Number 1
[12]
Gabriele C. DeLuca, Richard L. Yates, Harry Beale, and Sarah A. Morrow
Brain Pathology, 2015, Volume 25, Number 1, Page 79
[13]
Kathleen Borgmann and Anuja Ghorpade
Frontiers in Microbiology, 2015, Volume 6
[14]
Ana I. Amaral, Mussie G. Hadera, Joana M. Tavares, Mark R. N. Kotter, and Ursula Sonnewald
Glia, 2016, Volume 64, Number 1, Page 21
[15]
Karen S. Carvalho
Seminars in Pediatric Neurology, 2013, Volume 20, Number 3, Page 194
[16]
Grégory Ghézali, Glenn Dallérac, and Nathalie Rouach
Brain Structure and Function, 2016, Volume 221, Number 5, Page 2427
[17]
Varsha Manjunath and M. Tariq Bhatti
Canadian Journal of Ophthalmology / Journal Canadien d'Ophtalmologie, 2015, Volume 50, Number 1, Page e14
[18]
Petra Ehling, Manuela Cerina, Thomas Budde, Sven G. Meuth, and Stefan Bittner
Pflügers Archiv - European Journal of Physiology, 2015, Volume 467, Number 5, Page 959
[19]
Mark Noble, Margot Mayer-Pröschel, Zaibo Li, Tiefei Dong, Wanchang Cui, Christoph Pröschel, Ibro Ambeskovic, Joerg Dietrich, Ruolan Han, Yin Miranda Yang, Christopher Folts, Jennifer Stripay, Hsing-Yu Chen, and Brett M. Stevens
Free Radical Biology and Medicine, 2015, Volume 79, Page 300
[20]
Michelle Lee, Melody M Cheng, Chi-Ying Lin, Elan D Louis, Phyllis L Faust, and Sheng-Han Kuo
Acta Neuropathologica Communications, 2014, Volume 2, Number 1
[21]
Laetitia Wioland, Jean-Luc Dupont, Frédéric Doussau, Stéphane Gaillard, Flavia Heid, Philippe Isope, Serge Pauillac, Michel R. Popoff, Jean-Louis Bossu, and Bernard Poulain
Cellular Microbiology, 2015, Volume 17, Number 3, Page 369
[22]
Prejaas Tewarie, Menno M. Schoonheim, Daphne I. Schouten, Chris H. Polman, Lisanne J. Balk, Bernard M.J. Uitdehaag, Jeroen J.G. Geurts, Arjan Hillebrand, Frederik Barkhof, and Cornelis J. Stam
Human Brain Mapping, 2015, Volume 36, Number 2, Page 603
[23]
Stephen R. Lantz, Cina M. Mack, Kathleen Wallace, Ellen F. Key, Timothy J. Shafer, and John E. Casida
NeuroToxicology, 2014, Volume 45, Page 38
[24]
Claire J. Williams and David T. Dexter
Journal of Neurochemistry, 2014, Volume 129, Number 1, Page 4

Comments (0)

Please log in or register to comment.
Log in