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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John


IMPACT FACTOR 2018: 2.157
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CiteScore 2017: 2.81

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2191-0200
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Volume 24, Issue 1

Issues

The roles of MAGE-D1 in the neuronal functions and pathology of the central nervous system

Akihiro Mouri
  • Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Graduate School of Pharmacy, Nagoya 468-8503, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yukihiro Noda
  • Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Graduate School of Pharmacy, Nagoya 468-8503, Japan
  • Japanese Drug Organization of Appropriate Use and Research, Nagoya 468-0069, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ken Watanabe
  • Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Toshitaka Nabeshima
  • Corresponding author
  • Japanese Drug Organization of Appropriate Use and Research, Nagoya 468-0069, Japan
  • Department of Regional Pharmaceutical Care and Sciences, Meijo University, Nagoya 468-8503, Japan
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-01-09 | DOI: https://doi.org/10.1515/revneuro-2012-0069

Abstract

Melanoma-associated antigen-D1 (MAGE-D1) was discovered in bone marrow stromal cells. MAGE-D1 is detected in progenitor cells in the neuroepithelia and subventricular regions as well as in the postmitotic neuronal cells in the entire brain in the developing embryo and is also detected in most adult tissues, predominantly in the brain. Herein, we provide an overview of the roles of MAGE-D1 in the central nervous system. MAGE-D1 participates in neurotrophin-induced neuronal differentiation and survival by modulating Trk-dependent phosphorylation. MAGE-D1 regulates Dlx-dependent migration-related transcription by binding to necdin or praja-1. MAGE-D1 regulates a number of apoptotic pathways, each caused by distinct input signals, such as bone morphogenetic protein, p75 neurotrophin receptor, and uncoordinated gene-5 homologue. MAGE-D1 knockout mice show depressive behavior and impairments of circadian rhythm caused by decreased ubiquitylation of serotonin transporter and regulated transcription of RORα, respectively. The gene for necdin, a MAGE-D1-binding protein, has been described as responsible for Prader-Willi syndrome. In conclusion, MAGE-D1 plays important roles in the central nervous system in both developmental and adult stages and would be an invaluable target in the development of novel diagnostic and therapeutic agents for depression and Prader-Willi syndrome and also for providing new insights into the pathogenesis/pathophysiology of these diseases.

Keywords: apoptosis; circadian rhythm; depression; differentiation; MAGE-D1; migration

About the article

Akihiro Mouri

Akihiro Mouri, PhD, Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University.

Yukihiro Noda

Professor Yukihiro Noda, PhD, Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University.

Ken Watanabe

Ken Watanabe, PhD, Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology (NCGG).

Toshitaka Nabeshima

Professor Toshitaka Nabeshima, PhD, Department of Regional Pharmaceutical Care and Sciences, Faculty of Pharmacy, Meijo University.


Corresponding author: Toshitaka Nabeshima, Department of Regional Pharmaceutical Care and Sciences, Meijo University, Nagoya 468-8503, Japan


Received: 2012-08-19

Accepted: 2012-09-09

Published Online: 2013-01-09

Published in Print: 2013-02-01


Citation Information: Reviews in the Neurosciences, Volume 24, Issue 1, Pages 61–70, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2012-0069.

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