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Reviews in the Neurosciences

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Memory formation and memory alterations: 5-HT6 and 5-HT7 receptors, novel alternative

Alfredo Meneses
  • Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, Mexico City 14330, Mexico
  • :
Published Online: 2014-04-03 | DOI: https://doi.org/10.1515/revneuro-2014-0001

Abstract

Agonists and antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-HT6) or receptor7 (5-HT7) might improve memory and/or reverse amnesia, although the mechanisms involved are poorly understood. Hence, the current work summarizes recent reviews and findings involving these receptors. Evidence indicates that diverse 5-HT6 receptor antagonists produce promnesic and/or antiamnesic effect in conditions, such as memory formation, age-related cognitive impairments and memory deficit in preclinical studies, as well as in diseases such as schizophrenia, Parkinson’s, and Alzheimer’s disease (AD). Memory, aging, and AD modify 5-HT6 receptors and signaling cascades; likewise, the modulation of 5-HT6 drugs on memory seems to be accompanied with neural changes. Moreover, 5-HT7 receptors are localized in brain areas mediating memory, including the cortex, hippocampus (e.g., Zola-Morgan and Squire, 1993) and raphe nuclei; however, the role of these receptors on memory has yet to be fully explored. Hence, findings and reviews are summarized in this work. Evidence suggests that both 5-HT7 receptor agonists and antagonists might have promnesic and anti-amnesic effects. These effects seem to be dependent on the basal level of performance, i.e., normal or impaired. Available evidence suggests that a potential utility of 5-HT6 and 5-HT7 receptor in mild-to-moderate AD patients and other memory dysfunctions as therapeutic targets.

Keywords: drugs; memory; 5-HT receptors

Alfredo Meneses

Alfredo Meneses received his PhD in Physiological Sciences (1996) from Universidad Nacional Autónoma de Mexico (UNAM). He completed his postdoctoral stay at the NIA, USA from 1997 to 1998. Currently, he is a full Professor at the Department of Pharmacobiology of CINVESTAV. He was invited speaker for the Expert Workshop entitled, ‘Further Understanding of Serotonin 7 Receptors’ Neuropsychopharmacology’ (September 23, 2013, Rome). From 2013 to 2014, he completed two books for Elsevier by invitation, he is an invited editor for the Reviews in the Neuroscience and invited editor for Research Topic as well as associate editor for Frontiers in Pharmacology.

Corresponding author: Alfredo Meneses, Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, Mexico City 14330, Mexico, e-mail:


Received: 2013-12-03

Accepted: 2014-01-27

Published Online: 2014-04-03

Published in Print: 2014-06-01


Citation Information: Reviews in the Neurosciences. Volume 25, Issue 3, Pages 325–356, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2014-0001, April 2014

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