Jump to ContentJump to Main Navigation
Show Summary Details

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

IMPACT FACTOR 2015: 3.198
5-year IMPACT FACTOR: 3.546
Rank 97 out of 256 in category Neurosciences in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.605
Source Normalized Impact per Paper (SNIP) 2015: 0.912
Impact per Publication (IPP) 2015: 3.325

99,00 € / $149.00 / £75.00*

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Fetal alcohol spectrum disorders and cognitive functions of young children

1 / Eleana Gkioka1 / Vasileios Pergialiotis1 / Ioanna Mastroleon1 / Anastasia Prodromidou1 / Georgios D. Vlachos1 / Despina Perrea1

1Laboratory of Experimental Surgery and Surgical Research ‘N.S. Christeas’, National and Kapodistrian University of Athens Medical School, Agiou Thoma 15B, GR-11527 Athens, Greece

Corresponding author: Ioannis Bakoyiannis, Laboratory of Experimental Surgery and Surgical Research ‘N.S. Christeas’, National and Kapodistrian University of Athens Medical School, Agiou Thoma 15B, GR-11527 Athens, Greece, e-mail:

Citation Information: Reviews in the Neurosciences. Volume 25, Issue 5, Pages 631–639, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: 10.1515/revneuro-2014-0029, June 2014

Publication History

Published Online:


Fetal alcohol spectrum disorder (FASD) is one of the main causes of mental retardation worldwide. Nearly 1% of children in North America are affected from antenatal exposure to ethanol. Its economic burden in industrialized countries is increasing. It is estimated that, in the United States, 4.0 billion dollars are annually expended in the treatment and rehabilitation of these patients. As a pathologic entity, they present with a broad symptomatology. Fetal alcohol syndrome (FAS) is the most readily recognized clinical manifestation of these disorders. Various factors seem to contribute in the pathogenesis of FASD-related cognitive disorders. During the last 20 years, several potential pretranslational and posttranslational factors have been extensively studied in various experimental animal models. Research has specifically focused on several neurotransmitters, insulin resistance, alterations of the hypothalamic-pituitary-adrenal (HPA) axis, abnormal glycosylation of several proteins, oxidative stress, nutritional antioxidants, and various epigenetic factors. The purpose of the present review is to summarize the clinical manifestations of this disorder during childhood and adolescence and to summarize the possible pathophysiologic and epigenetic pathways that have been implicated in the pathophysiology of FASD.

Keywords: alcohol; cognitive; FASD

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

John F. Smiley, Mariko Saito, Cynthia Bleiwas, Kurt Masiello, Babak Ardekani, David N. Guilfoyle, Scott Gerum, Donald A. Wilson, and Csaba Vadasz
Alcohol, 2015
Mauro Ceccanti, Roberto Coccurello, Valentina Carito, Stefania Ciafrè, Giampiero Ferraguti, Giacomo Giacovazzo, Rosanna Mancinelli, Paola Tirassa, George N. Chaldakov, Esterina Pascale, Marco Ceccanti, Claudia Codazzo, and Marco Fiore
Addiction Biology, 2015, Page n/a

Comments (0)

Please log in or register to comment.