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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

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Volume 27, Issue 3


Angiotensin II-triggered kinase signaling cascade in the central nervous system

Anjana Bali
  • Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Amteshwar Singh Jaggi
  • Corresponding author
  • Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-11-17 | DOI: https://doi.org/10.1515/revneuro-2015-0041


Recent studies have projected the renin-angiotensin system as a central component of the physiological and pathological processes of assorted neurological disorders. Its primary effector hormone, angiotensin II (Ang II), not only mediates the physiological effects of vasoconstriction and blood pressure regulation in cardiovascular disease but is also implicated in a much wider range of neuronal activities and diseases, including Alzheimer’s disease, neuronal injury, and cognitive disorders. Ang II produces different actions by acting on its two subtypes of receptors (AT1 and AT2); however, the well-known physiological actions of Ang II are mainly mediated through AT1 receptors. Moreover, recent studies also suggest the important functional role of AT2 receptor in the brain. Ang II acts on AT1 receptors and conducts its functions via MAP kinases (ERK1/2, JNK, and p38MAPK), glycogen synthase kinase, Rho/ROCK kinase, receptor tyrosine kinases (PDGF and EGFR), and nonreceptor tyrosine kinases (Src, Pyk2, and JAK/STAT). AT1R-mediated NADPH oxidase activation also leads to the generation of reactive oxygen species, widely implicated in neuroinflammation. These signaling cascades lead to glutamate excitotoxicity, apoptosis, cerebral infarction, astrocyte proliferation, nociception, neuroinflammation, and progression of other neurological disorders. The present review focuses on the Ang II-triggered signal transduction pathways in central nervous system.

Keywords: angiotensin II; GSK 3, kinases; MAPK; p38 MAPK; Rho/ROCK kinase


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Corresponding author: Amteshwar Singh Jaggi, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India, e-mail: ;

Received: 2015-08-17

Accepted: 2015-09-26

Published Online: 2015-11-17

Published in Print: 2016-04-01

Citation Information: Reviews in the Neurosciences, Volume 27, Issue 3, Pages 301–315, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2015-0041.

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