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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

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Volume 27, Issue 5

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Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease: behavioral and neural studies

Ahmed A. Moustafa
  • Corresponding author
  • School of Social Sciences and Psychology and Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, New South Wales 2214, Australia
  • Department of Veterans Affairs, New Jersey Health Care System, East Orange, NJ 07018, USA
  • Email
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/ Srinivasa Chakravarthy / Joseph R. Phillips
  • School of Social Sciences and Psychology, Western Sydney University, Sydney, New South Wales, Australia
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/ Jacob J. Crouse
  • School of Social Sciences and Psychology, Western Sydney University, Sydney, New South Wales, Australia
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/ Ankur Gupta / Michael J. Frank
  • Department of Cognitive, Linguistic Sciences and Psychological Sciences, Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA
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/ Julie M. Hall
  • School of Social Sciences and Psychology, Western Sydney University, Sydney, New South Wales, Australia
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/ Marjan Jahanshahi
  • Cognitive Motor Neuroscience Group and Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK
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Published Online: 2016-03-16 | DOI: https://doi.org/10.1515/revneuro-2015-0070

Abstract

Parkinson’s disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how treatment of cognitive dysfunction, for example cognitive rehabilitation programs, may in turn influence the motor symptoms of PD.

Keywords: akinesia; bradykinesia; cognitive dysfunction; cognitive training; freezing of gait; grip force; Parkinson’s disease; postural instability; tremor

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About the article

Corresponding author: Ahmed A. Moustafa, School of Social Sciences and Psychology and Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, New South Wales 2214, Australia, e-mail: ; and Department of Veterans Affairs, New Jersey Health Care System, East Orange, NJ 07018, USA


Received: 2015-12-15

Accepted: 2016-02-21

Published Online: 2016-03-16

Published in Print: 2016-07-01


Citation Information: Reviews in the Neurosciences, Volume 27, Issue 5, Pages 535–548, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2015-0070.

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