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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John


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Volume 27, Issue 5

Issues

Postural instability and falls in Parkinson’s disease

Jacob J. Crouse
  • School of Social Sciences and Psychology, Western Sydney University, Sydney, New South Wales, 2214, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Joseph R. Phillips
  • School of Social Sciences and Psychology, Western Sydney University, Sydney, New South Wales, 2214, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marjan Jahanshahi
  • Cognitive Motor Neuroscience Group and Unit of Functional Neurosurgery Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery London, WC1N 3BG, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ahmed A. Moustafa
  • Corresponding author
  • School of Social Sciences and Psychology, Western Sydney University, Sydney, New South Wales, 2214, Australia
  • Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, New South Wales, 2214, Australia
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-03-11 | DOI: https://doi.org/10.1515/revneuro-2016-0002

Abstract

Postural instability (PI) is one of the most debilitating motor symptoms of Parkinson’s disease (PD), as it is associated with an increased risk of falls and subsequent medical complications (e.g. fractures), fear of falling, decreased mobility, self-restricted physical activity, social isolation, and decreased quality of life. The pathophysiological mechanisms underlying PI in PD remain elusive. This short review provides a critical summary of the literature on PI in PD, covering the clinical features, the neural and cognitive substrates, and the effects of dopaminergic medications and deep brain stimulation. The delayed effect of dopaminergic medication combined with the success of extrastriatal deep brain stimulation suggests that PI involves neurotransmitter systems other than dopamine and brain regions extending beyond the basal ganglia, further challenging the traditional view of PD as a predominantly single-system neurodegenerative disease.

Keywords: deep brain stimulation (DBS); dopamine; extrastriatal system; falls; Parkinson’s disease; postural instability

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About the article

Corresponding author: Ahmed A. Moustafa, School of Social Sciences and Psychology, Western Sydney University, Sydney, New South Wales, Australia, e-mail: ; and Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, New South Wales, 2214, Australia


Received: 2016-01-31

Accepted: 2016-02-14

Published Online: 2016-03-11

Published in Print: 2016-07-01


Citation Information: Reviews in the Neurosciences, Volume 27, Issue 5, Pages 549–555, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2016-0002.

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