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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

IMPACT FACTOR 2017: 2.590
5-year IMPACT FACTOR: 3.078

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 0.980
Source Normalized Impact per Paper (SNIP) 2017: 0.804

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Volume 28, Issue 7


Mild cognitive impairment in type 2 diabetes mellitus and related risk factors: a review

Xiao-Ying Yuan
  • Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian 116044, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Xu-Gang Wang
  • Corresponding author
  • Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. China
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-07-12 | DOI: https://doi.org/10.1515/revneuro-2017-0016


Type 2 diabetes mellitus (T2DM) is a global epidemic disease and has become a significant health problem. Many studies have raised concern about the mild cognitive impairment (MCI) with T2DM and even the Alzheimer’s disease patients with T2DM. The incidence of MCI is higher in individuals with T2DM than those without diabetes. Cognitive changes might affect everyday activities depending on the work and situation. Although the exact pathophysiology of MCI in T2DM is unclear, many studies suggest that the alterations in pathoglycemia, diabetic complications, related end products, and physical/psychological status are significant risk factors. In this article, we systematically overview the studies to illustrate the related risk factors of cognitive impairment in patients with T2DM. Further high quality studies and treatment need to be initiated and it will become incumbent on clinicians to identify and cure the earliest signs of clinical impairment.

Keywords: Alzheimer’s disease (AD); mild cognitive impairment (MCI); risk factor; type 2 diabetes mellitus (T2DM)


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About the article

Received: 2017-02-20

Accepted: 2017-04-18

Published Online: 2017-07-12

Published in Print: 2017-10-26

Citation Information: Reviews in the Neurosciences, Volume 28, Issue 7, Pages 715–723, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2017-0016.

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