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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

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Volume 28, Issue 7

Issues

The use of mesenchymal stem cells (MSCs) for amyotrophic lateral sclerosis (ALS) therapy – a perspective on cell biological mechanisms

Bor Luen TangORCID iD: http://orcid.org/0000-0002-1925-636X
  • Corresponding author
  • Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore
  • NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Medical Drive, Singapore 117597, Singapore
  • orcid.org/0000-0002-1925-636X
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-05-25 | DOI: https://doi.org/10.1515/revneuro-2017-0018

Abstract

Recent clinical trials of mesenchymal stem cells (MSCs) transplantation have demonstrated procedural safety and clinical proof of principle with a modest indication of benefit in patients with amyotrophic lateral sclerosis (ALS). While replacement therapy remained unrealistic, the clinical efficacy of this therapeutic option could be potentially enhanced if we could better decipher the mechanisms underlying some of the beneficial effects of transplanted cells, and work toward augmenting or combining these in a strategic manner. Novel ways whereby MSCs could act in modifying disease progression should also be explored. In this review, I discuss the known, emerging and postulated mechanisms of action underlying effects that transplanted MSCs may exert to promote motor neuron survival and/or to encourage regeneration in ALS. I shall also speculate on how transplanted cells may alter the diseased environment so as to minimize non-neuron cell autonomous damages by immune cells and astrocytes.

Keywords: amyotrophic lateral sclerosis (ALS); cell transplantation therapy; mesenchymal stem cells (MSC); motor neuron; neuroinflammation

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About the article

Received: 2017-02-27

Accepted: 2017-04-04

Published Online: 2017-05-25

Published in Print: 2017-10-26


Conflict of interest statement: The author declares that he has no conflict of interest.


Citation Information: Reviews in the Neurosciences, Volume 28, Issue 7, Pages 725–738, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2017-0018.

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