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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

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Volume 28, Issue 8


The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer’s disease

Yuan Zhang
  • Corresponding author
  • Institute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, P.R. China
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/ Xu Chen
  • Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, P.R. China
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  • De Gruyter OnlineGoogle Scholar
/ Yanfang Zhao
  • Institute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, P.R. China
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/ Murugavel Ponnusamy
  • Institute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, P.R. China
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/ Ying Liu
  • Institute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, P.R. China
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Published Online: 2017-07-12 | DOI: https://doi.org/10.1515/revneuro-2017-0013


Alzheimer’s disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly population. AD is associated with the buildup of β-amyloid and tau, which aggregate into extracellular plaques and neurofibrillary tangles. Although the exact mechanism of pathological process of AD is unclear, the dysfunction of protein degradation mechanisms has been proposed to play an important role in AD. The cellular degradation of abnormal or misfolded proteins consists of three different mechanisms: the ubiquitin proteasomal system (UPS), autophagy-lysosomal pathway (ALP), and interaction of molecular chaperones with UPS or ALP. Any disturbance to these systems causes proteins to accumulate, resulting in pathological process of AD. In this review, we summarize the knowledge of protein degradation pathways in the pathogenesis of AD in light of the current literature. In the future, the regulation UPS or ALP machineries could be the cornerstones of the treatment of AD.

Keywords: β-amyloid; Alzheimer disease; autophagy-lysosomal pathway; tau; ubiquitin proteasomal system


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About the article

Yuan Zhang and Xu Chen: These authors contributed equally to this work.

Received: 2017-02-16

Accepted: 2017-04-21

Published Online: 2017-07-12

Published in Print: 2017-11-27

Citation Information: Reviews in the Neurosciences, Volume 28, Issue 8, Pages 861–868, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2017-0013.

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