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Reviews in the Neurosciences

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Volume 29, Issue 8


Balo’s concentric sclerosis: an update and comprehensive literature review

Ali Amini Harandi
  • Corresponding author
  • Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1333635445, Iran
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/ Akram Esfandani
  • Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1333635445, Iran
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/ Hossein Pakdaman
  • Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1333635445, Iran
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/ Mehdi Abbasi
  • Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1333635445, Iran
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/ Mohammad Ali Sahraian
  • MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran 1136746911, Iran
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Published Online: 2018-05-16 | DOI: https://doi.org/10.1515/revneuro-2017-0096


Balo’s concentric sclerosis (BCS) is considered a variant of multiple sclerosis characterized by concentric lamella of alternating demyelinated and partially myelinated tissues. It is a rare and a relatively acute condition. Attacks may proceed rapidly over weeks or months, typically without remission, like Marburg’s variant, resulting in death or severe disability. However, the majority of cases have a more benign, self-limiting course with spontaneous remission. Magnetic resonance imaging is a primary imaging modality in the diagnosis of BCS. Treatment with intense immunosuppression may be indicated in patients with more aggressive form. New reports reveal more evidence regarding the pathophysiology and treatment strategies.

Keywords: Balo’s concentric sclerosis; demyelination; magnetic resonance imaging; multiple sclerosis


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About the article

Received: 2017-11-09

Accepted: 2018-03-10

Published Online: 2018-05-16

Published in Print: 2018-11-27

Conflict of interest statement: The authors declare that they have no conflict of interest to disclose.

Citation Information: Reviews in the Neurosciences, Volume 29, Issue 8, Pages 873–882, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2017-0096.

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