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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John


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Volume 30, Issue 1

Issues

Cannabidiol effects on prepulse inhibition in nonhuman primates

Patricia G. Saletti
  • Corresponding author
  • Albert Einstein College of Medicine, Rose F. Kennedy Center, Rm 310, 1410 Pelham Parkway South, Bronx, NY 10461, USA
  • Laboratory of Neurosciences and behavior, Department of Physiological Sciences, Institute of Biology, University of Brasilia, Brasilia, DF 70910-900, Brazil
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Carlos Tomaz
  • Laboratory of Neurosciences and behavior, Department of Physiological Sciences, Institute of Biology, University of Brasilia, Brasilia, DF 70910-900, Brazil
  • Neuroscience Research Group, University CEUMA, São Luís, MA 65075-120, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-05-24 | DOI: https://doi.org/10.1515/revneuro-2017-0101

Abstract

Prepulse inhibition (PPI) of acoustic startle reflex is a well-established behavior paradigm to measure sensorimotor gating deficits. PPI is disrupted in several neuropsychiatric disorders, including schizophrenia. PPI tests can be used to screen new drugs for treatment of such disorders. In this review, we discuss how PPI paradigm can help in screening the therapeutic effects of cannabidiol (CBD). We look into recent literature about CBD effects on PPI response in animal models, especially in nonhuman primates. CBD has been shown to modify PPI in N-methyl d-aspartate receptor antagonist models for schizophrenia, both in rodents and in nonhuman primates. These results show CBD as a potential drug for the treatment of neurologic disorders that present alterations in sensorimotor system, such as schizophrenia. Moreover, the PPI paradigm seems to be a useful and relative simple paradigm to test the efficacy of CBD as a potential therapeutic drug.

Keywords: cannabidiol (CBD); Cebus monkeys; endocannabinoid system; prepulse inhibition (PPI); schizophrenia

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About the article

aCurrent address: Laboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA


Received: 2017-11-26

Accepted: 2018-03-29

Published Online: 2018-05-24

Published in Print: 2018-12-19


Citation Information: Reviews in the Neurosciences, Volume 30, Issue 1, Pages 95–105, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2017-0101.

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