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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Gold, Paul / Holsboer, Florian / Korth, Carsten / Li, Jay-Shake / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

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Volume 30, Issue 3


The optimal choices of animal models of white matter injury

Yan Zeng
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China
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/ Huiqing Wang
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China
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/ Li Zhang
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China
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/ Jun Tang
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China
  • Other articles by this author:
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/ Jing Shi
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China
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  • De Gruyter OnlineGoogle Scholar
/ Dongqiong Xiao
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China
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  • De Gruyter OnlineGoogle Scholar
/ Yi Qu
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China
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  • De Gruyter OnlineGoogle Scholar
/ Dezhi Mu
  • Corresponding author
  • Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, section 3, Renmin South Road, Chengdu, Sichuan 610041, China
  • Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu 610041, China, Telephone: +86-28-85503226, Fax: +86-28-85559065
  • Email
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Published Online: 2018-10-31 | DOI: https://doi.org/10.1515/revneuro-2018-0044


White matter injury, the most common neurological injury in preterm infants, is a major cause of chronic neurological morbidity, including cerebral palsy. Although there has been great progress in the study of the mechanism of white matter injury in newborn infants, its pathogenesis is not entirely clear, and further treatment approaches are required. Animal models are the basis of study in pathogenesis, treatment, and prognosis of white matter injury in preterm infants. Various species have been used to establish white matter injury models, including rodents, rabbits, sheep, and non-human primates. Small animal models allow cost-effective investigation of molecular and cellular mechanisms, while large animal models are particularly attractive for pathophysiological and clinical-translational studies. This review focuses on the features of commonly used white matter injury animal models, including their modelling methods, advantages, and limitations, and addresses some clinically relevant animal models that allow reproduction of the insults associated with clinical conditions that contribute to white matter injury in human infants.

Keywords: advantages; animal model; histological changes; limitations; white matter injury


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About the article

aYan Zeng and Huiqing Wang: These authors contributed equally to this article.

Received: 2018-05-01

Accepted: 2018-06-16

Published Online: 2018-10-31

Published in Print: 2019-04-24

Funding Source: National Natural Science Foundation of China

Award identifier / Grant number: 81330016

Award identifier / Grant number: 81630038

Award identifier / Grant number: 81330524

Award identifier / Grant number: 81771634

This work was supported by the National Science Foundation of China (Funder Id: 10.13039/501100001809, No. 81330016, 81630038, 81330524, 81771634), the National Key R&D Program of China (2017YFA0104200), grants from Ministry of Education of China (IRT0935), grants from the Science and Technology Bureau of Sichuan Province (2016TD0002), and a grant of the Clinical Discipline Program (Neonatology) from the Ministry of Health of China (1311200003303).

Citation Information: Reviews in the Neurosciences, Volume 30, Issue 3, Pages 245–259, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2018-0044.

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