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Reviews in the Neurosciences

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Volume 26, Issue 2 (Apr 2015)

Issues

Schwann cell transplantation for spinal cord injury repair: its significant therapeutic potential and prospectus

Haruo Kanno
  • Corresponding author
  • The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
  • Email:
/ Damien D. Pearse
  • The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL33136, USA
  • Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
/ Hiroshi Ozawa
  • Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
/ Eiji Itoi
  • Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
/ Mary Bartlett Bunge
  • The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL33136, USA
  • Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Published Online: 2015-01-10 | DOI: https://doi.org/10.1515/revneuro-2014-0068

Abstract

Transplantation of Schwann cells (SCs) is a promising therapeutic strategy for spinal cord repair. The introduction of SCs into the injured spinal cord has been shown to reduce tissue loss, promote axonal regeneration, and facilitate myelination of axons for improved sensorimotor function. The pathology of spinal cord injury (SCI) comprises multiple processes characterized by extensive cell death, development of a milieu inhibitory to growth, and glial scar formation, which together limits axonal regeneration. Many studies have suggested that significant functional recovery following SCI will not be possible with a single therapeutic strategy. The use of additional approaches with SC transplantation may be needed for successful axonal regeneration and sufficient functional recovery after SCI. An example of such a combination strategy with SC transplantation has been the complementary administration of neuroprotective agents/growth factors, which improves the effect of SCs after SCI. Suspension of SCs in bioactive matrices can also enhance transplanted SC survival and increase their capacity for supporting axonal regeneration in the injured spinal cord. Inhibition of glial scar formation produces a more permissive interface between the SC transplant and host spinal cord for axonal growth. Co-transplantation of SCs and other types of cells such as olfactory ensheathing cells, bone marrow mesenchymal stromal cells, and neural stem cells can be a more effective therapy than transplantation of SCs alone following SCI. This article reviews some of the evidence supporting the combination of SC transplantation with additional strategies for SCI repair and presents a prospectus for achieving better outcomes for persons with SCI.

Keywords: axonal regeneration; clinical trial; neuroprotection; transplantation

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About the article

Corresponding author: Haruo Kanno, Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan, e-mail: ; and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA


Received: 2014-09-30

Accepted: 2014-10-16

Published Online: 2015-01-10

Published in Print: 2015-04-01


Citation Information: Reviews in the Neurosciences, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2014-0068. Export Citation

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