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Reviews in the Neurosciences

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Volume 27, Issue 5


Regulation of neuronal-glial fate specification by long non-coding RNAs

Lei Wang
  • Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Central South University, Haikou 570100, China
  • Other articles by this author:
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/ Yan Liu / Shaiqi Sun
  • Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Central South University, Haikou 570100, China
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/ Ming Lu
  • Corresponding author
  • Department of Neurosurgery, the Second Affiliated Hospital of Hunan Normal University (PLA 163 Hospital), Cangsha 41000, China
  • Email
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/ Ying Xia
  • Corresponding author
  • Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Central South University, Haikou 570100, China
  • Email
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Published Online: 2016-03-04 | DOI: https://doi.org/10.1515/revneuro-2015-0061


Neural stem cell transplantation is becoming a promising and attractive cell-based treatment modality for repairing the damaged central nervous system. One of the limitations of this approach is that the proportion of functional cells differentiated from stem cells still remains at a low level. In recent years, novel long non-coding RNAs (lncRNAs) are being discovered at a growing pace, suggesting that this class of molecules may act as novel regulators in neuronal-glial fate specification. In this review, we first describe the general features of lncRNAs that are more likely to be relevant to reveal their function. By this, we aim to point out the specific roles of a number of lncRNAs whose function has been described during neuronal and glial cell differentiation. There is no doubt that investigation of the lncRNAs will open a new window in studying neuronal-glial fate specification.

Keywords: differentiation; gliogenesis; lncRNAs; neurogenesis


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About the article

Corresponding authors: Ming Lu, Department of Neurosurgery, the Second Affiliated Hospital of Hunan Normal University (PLA 163 Hospital), Cangsha 41000, China, e-mail: ; and Ying Xia, Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Central South University, Haikou 570100, China, e-mail:

aLei Wang and Yan Liu: These authors contributed equally to this work.

Received: 2015-10-29

Accepted: 2016-02-06

Published Online: 2016-03-04

Published in Print: 2016-07-01

Conflict of interest disclosure: The authors have no conflicts of interest to disclose.

Citation Information: Reviews in the Neurosciences, Volume 27, Issue 5, Pages 491–499, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2015-0061.

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