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Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John


IMPACT FACTOR 2015: 3.198
5-year IMPACT FACTOR: 3.546
Rank 97 out of 256 in category Neurosciences in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.605
Source Normalized Impact per Paper (SNIP) 2015: 0.912
Impact per Publication (IPP) 2015: 3.325

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2191-0200
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Regulation of neuronal-glial fate specification by long non-coding RNAs

Lei Wang1, a / Yan Liu2, a / Shaiqi Sun1 / 3 / 1

1Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Central South University, Haikou 570100, China

2Department of neurology, Changsha City Central Hospital, Changsha 41000, China

3Department of Neurosurgery, the Second Affiliated Hospital of Hunan Normal University (PLA 163 Hospital), Cangsha 41000, China

Corresponding authors: Ming Lu, Department of Neurosurgery, the Second Affiliated Hospital of Hunan Normal University (PLA 163 Hospital), Cangsha 41000, China, e-mail: ; and Ying Xia, Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Central South University, Haikou 570100, China, e-mail:

aLei Wang and Yan Liu: These authors contributed equally to this work.

Citation Information: Reviews in the Neurosciences. Volume 27, Issue 5, Pages 491–499, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2015-0061, March 2016

Publication History

Received:
2015-10-29
Accepted:
2016-02-06
Published Online:
2016-03-04

Abstract

Neural stem cell transplantation is becoming a promising and attractive cell-based treatment modality for repairing the damaged central nervous system. One of the limitations of this approach is that the proportion of functional cells differentiated from stem cells still remains at a low level. In recent years, novel long non-coding RNAs (lncRNAs) are being discovered at a growing pace, suggesting that this class of molecules may act as novel regulators in neuronal-glial fate specification. In this review, we first describe the general features of lncRNAs that are more likely to be relevant to reveal their function. By this, we aim to point out the specific roles of a number of lncRNAs whose function has been described during neuronal and glial cell differentiation. There is no doubt that investigation of the lncRNAs will open a new window in studying neuronal-glial fate specification.

Keywords: differentiation; gliogenesis; lncRNAs; neurogenesis

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