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Volume 27, Issue 7 (Oct 2016)


Use of electrospinning to construct biomaterials for peripheral nerve regeneration

Qi Quan
  • Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China
/ Biao Chang
  • Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China
/ Hao Ye Meng
  • Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China
/ Ruo Xi Liu
  • Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China
/ Yu Wang
  • Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China
/ Shi Bi Lu
  • Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China
/ Jiang Peng
  • Corresponding author
  • Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, 28 FuXing Road, Beijing 100853, People’s Republic of China
  • Email:
/ Qing Zhao
  • Corresponding author
  • Department of Orthopedic Surgery, First Affiliated Hospital of PLA General Hospital, 51 FuCheng Road, Beijing 100048, People’s Republic of China
  • Email:
Published Online: 2016-07-18 | DOI: https://doi.org/10.1515/revneuro-2016-0032


A number of limitations associated with the use of hollow nerve guidance conduits (NGCs) require further discussion. Most importantly, the functional recovery outcomes after the placement of hollow NGCs are poor even after the successful bridging of peripheral nerve injuries. However, nerve regeneration scaffolds built using electric spinning have several advantages that may improve functional recovery. Thus, the present study summarizes recent developments in this area, including the key cells that are combined with the scaffold and associated with nerve regeneration, the structure and configuration of the electrospinning design (which determines the performance of the electrospinning scaffold), the materials the electrospinning fibers are composed of, and the methods used to control the morphology of a single fiber. Additionally, this study also discusses the processes underlying peripheral nerve regeneration. The primary goals of the present review were to evaluate and consolidate the findings of studies that used scaffolding biomaterials built by electrospinning used for peripheral nerve regeneration support. It is amazing that the field of peripheral nerve regeneration continues to consistently produce such a wide variety of innovative techniques and novel types of equipment, because the introduction of every new process creates an opportunity for advances in materials for nerve repair.

Keywords: electrospinning; nanofiber scaffold; peripheral nerve regeneration


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About the article

aQi Quan and Biao Chang: These authors contributed equally to this work.

Received: 2016-05-13

Accepted: 2016-05-26

Published Online: 2016-07-18

Published in Print: 2016-10-01

Funding Source: National Natural Science Foundation of China

Award identifier / Grant number: 51073024

Award identifier / Grant number: 51273021

The authors received funding from the National Natural Science Foundation of China (51073024, 51273021), 973 (2014CB542201 and 2012CB518106), the Special Project of the ‘Thirteenth Five-year Plan’ for medical Science Development of PLA (BWS13C029), and the Special Project of the ‘Twelfth–Five-year Plan’ for medical Science Development of PLA (BWS11J025).

Conflict of interest statement: The authors declare that they have no conflict of interest.

Citation Information: Reviews in the Neurosciences, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2016-0032.

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