Adya, R., Tan, B. K., and Randeva H. S. (2015). Differential effects of leptin and adiponectin in endothelial angiogenesis. J Diabetes Res. 2015, 648239.Google Scholar
Ahima, R.S. and Osei, S.Y. (2004). Leptin signaling. Physiol. Behav. 81, 223–241.Google Scholar
Aleidi, S., Issa, A., Bustanji, H., Khalil M., and Bustanji Y. (2015). Adiponectin serum levels correlate with insulin resistance in type 2 diabetic patients. Saudi Pharm. J. 23, 250–256.Google Scholar
Aprahamian, T.R. and Sam, F. (2011). Adiponectin in cardiovascular inflammation and obesity. Int. J. Inflam. 2011, 376909.Google Scholar
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999). Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257, 79–83.Google Scholar
Bailleul, B., Akerblom, I., and Strosberg, A.D. (1997). The leptin receptor promoter controls expression of a second distinct protein. Nucleic Acids Res. 25, 2752–2758.Google Scholar
Bang, O.Y., Saver, J.L., Ovbiagele, B., Choi, Y.J., Yoon, S.R., and Lee, K.H. (2007). Adiponectin levels in patients with intracranial atherosclerosis. Neurology 22, 1931–1937.Google Scholar
Beltowski, J. (2006). Leptin and atherosclerosis. Atherosclerosis 189, 47–60.Google Scholar
Berg, A.H., Combs, T.P., Du, X., Brownlee, M., and Scherer, P.E. (2001). The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947–953.Google Scholar
Berg, A.H., Combs, T.P., and Scherer, P.E. (2002). ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol. Metab. 13, 84–89.Google Scholar
Bidulescu, A., Liu, J., Chen, Z., Hickson, D.A., Musani, S.K., Samdarshi, T.E., Fox, E.R., Taylor, H.A., and Gibbons, G.H. (2013). Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in African Americans: the Jackson Heart Study. Front. Public Health 1, 16.Google Scholar
Blumer, R.M., van Roomen, C.P., Meijer, A.J., Houben-Weerts, J.H., Sauerwein, H.P., and Dubbelhuis, P.F. (2008). Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes. Metabolism 57, 1655–1662.Google Scholar
Bodary, P.F. and Eitzman, D.T. (2006). Adiponectin: vascular protection from the fat? Arterioscler. Thromb. Vasc. Biol. 26, 235–236.Google Scholar
Bodles, A.M., Banga, A., Rasouli, N., Ono, F., Kern, P.A., and Owens, R.J. (2006). Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes. Am. J. Physiol. Endocrinol. Metab. 291, E1100–E1105.Google Scholar
Bouloumie, A., Marumo, T., Lafontan, M., and Busse, R. (1999). Leptin induces oxidative stress in human endothelial cells. FASEB J. 13, 1231–1238.Google Scholar
Bouloumié, A., Curat, C.A., Sengenès, C., Lolmède, K., Alexandra M., and Busse, R. (2005). Role of Macrophage tissue infiltration in metabolic diseases. Curr. Opin. Clin. Nutr. Metab. Care 8, 347–54.Google Scholar
Buechler, C., Wanninger, J., and Neumeier, M. (2010). Adiponectin receptor binding proteins—recent advances in elucidating adiponectin signalling pathways. FEBS Lett. 584, 4280–4286.Google Scholar
Caselli, C., D’Amico, A., Cabiati, M., Prescimone, T., Del Ry, S., and Giannessi, D. (2014). Back to the heart: the protective role of adiponectin. Pharmacol. Res. 82, 9–20.Google Scholar
Chen, H., Montagnani, M., Funahashi, T., Shimomura, I., and Quon, M.J. (2003). Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J. Biol. Chem. 278, 45021–45026.Google Scholar
Chen, M.P., Tsai, J.C., Chung, F.M., Yang, S.S., Hsing, L.L., Shin, S.J., and Lee, Y.J. (2005). Hypoadiponectinemia is associated with ischemic cerebrovascular disease. Arterioscler. Thromb. Vasc. Biol. 25, 821–826.Google Scholar
Chen, K., Li, F., Li, J., Cai, H., Strom, S., Bisello, A., Kelley, D.E., Friedman-Einat, M., Skibinski, G.A., McCrory, M.A. (2006). Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat. Med. 12, 425–432.Google Scholar
Chen, B., Liao, W.Q., Xu, N., Xu., H., Wen, J.Y., Yu, C.A., Liu, X.Y., Li, C.L., Zhao, S.M., and Campbell, W. (2009). Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action. Brain Res. 1273, 129–137.Google Scholar
Cioffi, J.A., Shafer, A.W., Zupancic, T.J., Smith-Gbur, J., Mikhail, A., Platika, D., and Snodgrass, H.R. (1996). Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2, 585–589.Google Scholar
Clement, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.M., et al. (1998). A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392. 398–401.Google Scholar
Corsonello, A., Perticone, F., Malara, A., De Domenico, D., Loddo, S., Buemi, M., Ientile, R., and Corica, F. (2003). Leptin-dependent platelet aggregation in healthy, overweight and obese subjects. Int. J. Obes. Relat. Metab. Disord. 27, 566–573.Google Scholar
Deb, P., Sharma, S., and Hassan, K.M. (2010). Pathophysiologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology 17, 197–218.Google Scholar
Dichgans, M. (2007). Genetics of ischaemic stroke. Lancet Neurol. 6, 149–161.Google Scholar
Fazeli, M., Zarkesh-Esfahani, H., Wu, Z., Maamra, M., Bidlingmaier, M., Pockley, A.G., Watson, P., Matarese, G., Strasburger, C.J., and Ross, R.J. (2006). Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation. J. Immunol. Methods 312, 190–200.Google Scholar
Feigin, V.L., Forouzanfar, M.H., Krishnamurthi, R., Mensah, G.A., Connor, M., Bennett, D.A., Moran, A.E., Sacco, R.L., Anderson, L., Truelsen, T., et al. (2014). Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study. Lancet 383, 245–254.Google Scholar
Fisman, E.Z. and Tenenbaum, A. (2014). Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease? Cardiovasc. Diabetol. 13, 103.Google Scholar
Friedman, J.M. (2009). Leptin at 14 y of age: an ongoing story. Am. J. Clin. Nutr. 89, 973S–979S.Google Scholar
Fruhbeck, G. (2006). Intracellular signalling pathways activated by leptin. Biochem. J. 393, 7–20.Google Scholar
Grunfeld, C., Zhao, C., Fuller, J., Pollack, A., Moser, A., Friedman, J., and. Feingold, K.R. (1996). Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J. Clin. Invest. 97, 2152–2157.Google Scholar
Gu, P. and Xu, A. (2013). Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction. Rev. Endocr. Metab. Disord. 14, 49–58.Google Scholar
Hada, Y., Yamauchi, T., Waki, H., Tsuchida, A., Hara, K., Yago, H., Miyazaki, O., Ebinuma, H., and Kadowaki, T. (2007). Selective purification and characterization of adiponectin multimer species from human plasma. Biochem. Biophys. Res. Commun. 356, 487–493.Google Scholar
Hattori, Y., Nakano, Y., Hattori, S., Tomizawa, A., Inukai, K., and Kasai, K. (2008). High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells. FEBS Lett. 582, 1719–1724.Google Scholar
Hribal, M.L., Fiorentino, T.V., and Sesti, G. (2014). Role of C reactive protein (CRP) in leptin resistance. Curr. Pharm. Des. 20, 609–615.Google Scholar
Hu, E., Liang, P., and Spiegelman, B.M. (1996). AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697–10703.Google Scholar
Hukshorn, C.J. and Saris, W.H. (2004). Leptin and energy expenditure. Curr. Opin. Clin. Nutr. Metab. Care 7, 629–633.Google Scholar
Imagawa, K., Numata, Y., Katsuura, G., Sakaguchi, I., Morita, A., Kikuoka, S., Matumoto, Y., Tsuji, T., Tamaki, M., Sasakura, K., et al. (1998). Structure-function studies of human leptin. J. Biol. Chem. 273, 35245–35249.Google Scholar
Isse, N., Ogawa, Y., Tamura, N., Masuzaki, H., Mori, K., Okazaki, T., Satoh, N., Shigemoto, M., Yoshimasa, Y., Nishi S., et al. (1995). Structural organization and chromosomal assignment of the human obese gene. J. Biol. Chem. 270, 27728–27733.Google Scholar
Iwashima, Y., Katsuya, T., Ishikawa, K., Ouchi, N., Ohishi, M., Sugimoto, K., Fu, Y., Motone, M., Yamamoto, K., Matsuo, A., et al. (2004). Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 43, 1318–1323.Google Scholar
Jaleel, A., Aqil, S., Jaleel, S., and Jaleel, F. (2010). Adipocytokines in subjects with and without ischemic cerebrovascular disease. Acta Neurol. Belg. 110, 234–238.Google Scholar
Jin, R., Yang, G., and Li, G. (2010). Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J. Leukoc. Biol. 87, 779–789.Google Scholar
Juge-Aubry, C.E., Henrichot, E., and Meier, C.A. (2005). Adipose tissue: a regulator of inflammation. Best Pract. Res. Clin. Endocrinol. Metab. 19, 547–66.Google Scholar
Kadowaki, T. and Yamauchi, T. (2005). Adiponectin and adiponectin receptors. Endocr. Rev. 26, 439–451.Google Scholar
Kantorova, E., Chomova, M., Kurca, E., Sivak, S., Zelenak, K., Kucera, P., and Galajda, P. (2011). Leptin, adiponectin and ghrelin, new potential mediators of ischemic stroke. Neurol. Endocrinol. Lett. 32, 716–721.Google Scholar
Kantorová, E., Jesenská, Ľ., Čierny, D., Zeleňák, K., Sivák, S., Stančík, M., Galajda, P., Nosáľ, V., and Kurča, E. (2015). The intricate network of adipokines and stroke. Int. J. Endocrinol. 2015, 967698.Google Scholar
Kato, H., Kashiwagi, H., Shiraga, M., Tadokoro, S., Kamae, T., Ujiie, H., Honda, S., Miyata, S., Ijiri, Y., Yamamoto, J., et al. (2006). Adiponectin acts as an endogenous antithrombotic factor. Arterioscler. Thromb. Vasc. Biol. 26, 224–230.Google Scholar
Kershaw, E.E. and Flier, J.S. (2004). Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89, 2548–2556.Google Scholar
Kielar, D., Clark, J.S., Ciechanowicz, A., Kurzawski, G., Sulikowski, T., and Naruszewicz, M. (1998). Leptin receptor isoforms expressed in human adipose tissue. Metabolism 47, 844–847.Google Scholar
Kim, B.J., Lee, S.H., Ryu, W.S., Kim, C.K., and Yoon, B.W. (2012). Adipocytokines and ischemic stroke: differential associations between stroke subtypes. J. Neurol. Sci. 312, 117–122.Google Scholar
Koh, K.K., Park., S.M., and Quon, M.J. (2008). Leptin and cardiovascular disease: response to therapeutic interventions. Circulation 117, 3238–3249.Google Scholar
Konstantinides, S., Schafer, K., Koschnick, S., and Loskutoff, D.J. (2001). Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J. Clin. Invest. 108, 1533–1540.Google Scholar
La Cava, A. and Matarese, G. (2004).The weight of leptin in immunity. Nat. Rev. Immunol. 4, 371–379.Google Scholar
Lago, F., Dieguez, C., Gómez-Reino, J., and Gualillo, O. (2007). Adipokines as emerging mediators of immune response and inflammation. Nat. Clin. Pract. Rheumatol. 3, 716–24.Google Scholar
Lakhan, S.E., Kirchgessner, A., and Hofer, M. (2009). Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J. Transl. Med. 7, 97.Google Scholar
Lam, Q.L. and Lu, L. (2007). Role of leptin in immunity. Cell. Mol. Immunol. 4, 1–13.Google Scholar
Lambertsen, K.L., Biber, K., and Finsen, B. (2012). Inflammatory cytokines in experimental and human stroke. J. Cereb. Blood. Flow. Metab. 32, 1677–1698.Google Scholar
Lee, C.H. and Hung, Y.J. (2015). Possible new therapeutic approach for obesity-related diseases: role of adiponectin receptor agonists. J. Diabetes Invest. 6, 264–66.Google Scholar
Lee, G.H., Proenca, R., Montez, J.M., Carroll, K.M., Darvishzadeh, J.G., Lee, J.I., and Friedman, J.M. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632–635.Google Scholar
Libby, P. (2002). Inflammation in atherosclerosis. Nature 420, 868–74.Google Scholar
Liu, J. and Wang, L.N. (2014).Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack. Cochrane Database Syst. Rev. 1, CD010693.Google Scholar
Liu, J., Butler, K.R., Buxbaum, S.G., Sung, J.H., Campbell, B.W., and Taylor, H.A. (2010). Leptinemia and its association with stroke and coronary heart disease in the Jackson Heart Study. Clin. Endocrinol. (Oxf). 72, 32–37.Google Scholar
Lord, G.M., Matarese, G., Howard, J.K., Baker, R.J., Bloom, S.R., and Lechler, R.I. (1998). Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897–901.Google Scholar
MacDougald, O.A. and Burant, C.F. (2007). The rapidly expanding family of adipokines. Cell Metab. 6, 159–161.Google Scholar
Margetic, S., Gazzola, C., Pegg, G.G., and Hill, R.A. (2002).Leptin: a review of its peripheral actions and interactions. Int. J. Obes. Relat. Metab. Disord. 26, 1407–1433.Google Scholar
Martin-Romero, C., Santos-Alvarez, J., Goberna, R., and Sanchez-Margalet, V. (2000). Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell. Immunol. 199, 15–24.Google Scholar
Matarese, G. (2000). Leptin and the immune system: how nutritional status influences the immune response. Eur. Cytokine Netw. 11, 7–14.Google Scholar
Matarese, G., Moschos, S., and Mantzoros, C.S. (2005). Leptin in Immunology. J. Immunol. 174, 3137–3142.Google Scholar
Matsubara, M., Maruoka, S., and Katayose, S. (2002). Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur. J. Endocrinol. 14, 173–180.Google Scholar
Matsumoto, M., Ishikawa, S., and Kajii, E. (2008). Association of adiponectin with cerebrovascular disease: a nested case-control study. Stroke 39, 323–328.Google Scholar
Mertens, I., Ballaux, D., Funahashi, T., Matsuzawa, Y., Van der Planken, M., Verrijken, A., Ruige, J.B., and Van Gaal, L.F. (2005). Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation. Thromb. Haemost. 94, 1190–1195.Google Scholar
Nakamura, Y., Ueshima, H., Okuda, N., Miura, K., Kita, Y., Okamura, T., Okayama, A., Choudhury, S.R., Rodriguez, B., Masaki, K.H., et al. (2013). Relation of serum leptin and adiponectin level to serum c-reactive protein: the INTERLIPID Study. Int. J. Vasc. Med. 2013, 601364.Google Scholar
Nakata, M., Yada, T., Soejima, N., and Maruyama, I. (1999). Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 48, 426–429.Google Scholar
Nakatsuji, H., Kobayashi, H., Kishida, K., Nakagawa, T., Takahashi, S., Tanaka, H., Akamatsu, S., Funahashi, T., and Shimomura, I. (2013). Binding of adiponectin and C1q in human serum, and clinical significance of the measurement of C1q-adiponectin/total adiponectin ratio. Metabolism 62, 109–120.Google Scholar
Nishimura, M., Izumiya, Y., Higuchi, A., Shibata, R., Qiu, J., Kudo, C., Shin, H.K., Moskowitz, M.A., and Ouchi, N. (2008). Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation 117, 216–223.Google Scholar
Norata, G.D., Raselli, S., Grigore, L., Garlaschelli, K., Dozio, E., Magni, P., and Catapano, A.L. (2007). Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery. Stroke 38, 2844–2846.Google Scholar
Ogawa, Y., Masuzaki, H., Isse, N., Okazaki, T., Mori, K., Shigemoto, M., Satoh, N., Tamura, N., Hosoda, K., and Yoshimasa, Y. (1995). Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J. Clin. Invest. 96, 1647–1652.Google Scholar
Ohashi, K., Ouchi, N., and Matsuzawa, Y. (2012). Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie 94, 2137–2142.Google Scholar
Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013). A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503, 493–499.Google Scholar
Ouchi, N. and Walsh, K. (2007). Adiponectin as an anti-inflammatory factor. Clin. Chim. Acta 380, 24–30.Google Scholar
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999). Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100, 2473–2476.Google Scholar
Ouchi, N., Kihara, S., Arita, Y., Nishida, M., Matsuyama, A., Okamoto, Y., Ishigami, M., Kuriyama, H., Kishida, K., Nishizawa, H., et al. (2001). Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103, 1057–1063.Google Scholar
Ouchi, N., Kihara, S., Funahashi, T., Nakamura, T., Nishida, M., Kumada, M., Okamoto, Y., Ohashi, K., Nagaretani, H., Kishida, K., et al. (2003). Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107, 671–674.Google Scholar
Ouedraogo, R., Wu, X., Xu, S.Q., Fuchsel, L., Motoshima, H., Mahadev, K., Hough, K., Scalia, R., and Goldstein, B.J. (2006). Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 55, 1840–1846.Google Scholar
Pajvani, U.B., Du, X., Combs, T.P., Berg, A.H., Rajala, M.W., Schulthess, T., Engel, J., Brownlee, M., and Scherer, P.E. (2003). Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J. Biol. Chem. 278, 9073–9085.Google Scholar
Procaccini, C., Jirillo, E., and Matarese, G. (2012). Leptin as an immunomodulator. Mol. Aspects Med. 33, 35–45.Google Scholar
Prugger, C., Luc, G., Haas, B., Arveiler, D., Machez, E., Ferrieres, J., Ruidavets, J.B., Bingham, A., Montaye, M., Amouyel, P., et al. (2012). Adipocytokines and the risk of ischemic stroke: the PRIME Study. Ann. Neurol. 71, 478–486.Google Scholar
Rajpathak, S.N., Kaplan, R.C., Wassertheil-Smoller, S., Cushman, M., Rohan, T.E., McGinn, A.P., Wang, T., Strickler, H.D., Scherer, P.E., Mackey, R., et al. (2011). Resistin, but not adiponectin and leptin, is associated with the risk of ischemic stroke among postmenopausal women: results from the Women’s Health Initiative. Stroke 42, 1813–1820.Google Scholar
Romero, JR., Morris, J., and Pikula, A. (2008). Stroke prevention: modifying risk factors. Ther. Adv. Cardiovasc. Dis. 2, 287–303.Google Scholar
Romero-Corral, A., Sierra-Johnson, J., Lopez-Jimenez, F., Thomas, R.J., Singh, P., Hoffmann, M., Okcay, A., Korinek, J., Wolk, R., and Somers, V.K. (2008). Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat. Clin. Pract. Cardiovasc. Med. 5, 418–425.Google Scholar
Rosamond, W., Flegal, K., Furie, K., Go, A., Greenlund, K., Haase, N., Hailpern, S.M., Ho, M., Howard, V., Kissela, B., et al., American Heart Association Statistics and S. Stroke Statistics. (2008). Heart disease and stroke statistics—2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117, e25–e146.Google Scholar
Saito, K., Tobe, T., Minoshima, S., Asakawa, S., Sumiya, J., Yoda, M., Nakano, Y., Shimizu, N., and Tomita, M. (1999). Organization of the gene for gelatin-binding protein (GBP28). Gene 229, 67–73.Google Scholar
Sanchez-Margalet, V., Martin-Romero, C., Santos-Alvarez, J., Goberna, R., Najib, S., and Gonzalez-Yanes, C. (2003). Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin. Exp. Immunol. 133, 11–19.Google Scholar
Saxena, N.K., Sharma, D., Ding, X., Lin, S., Marra, F., Merlin, D., and Anania, F.A. (2007). Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res. 67, 2497–2507.Google Scholar
Scherer, P.E., Williams, S., Fogliano, M., Baldini, G., and Lodish, H.F. (1995). A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746–26749.Google Scholar
Schneiderman, J., Schaefer, K., Kolodgie, F.D., Savion, N., Kotev-Emeth, S., Dardik, R., Simon, A.J., Halak, M., Pariente, C., Engelberg, I., et al. (2012). Leptin locally synthesized in carotid atherosclerotic plaques could be associated with lesion instability and cerebral emboli. J. Am. Heart. Assoc. 1, e001727.Google Scholar
Shamsuzzaman, A.S., Winnicki, M., Wolk, R., Svatikova, A., Phillips, B.G., Davison, D.E., Berger, P.B., and Somers, V.K. (2004). Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation 109, 2181–2185.Google Scholar
Shapiro, L. and Scherer, P.E. (1998). The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 8, 335–338.Google Scholar
Shibata, R., Murohara, T., and Ouchi, N. (2012). Protective role of adiponectin in cardiovascular disease. Curr. Med. Chem. 19, 5459–5466.Google Scholar
Shimada, K., Miyazaki, T., and Daida, H. (2004).Adiponectin and atherosclerotic disease. Clin. Chim. Acta 344, 1–12.Google Scholar
Siitonen, N., Pulkkinen, L., Lindstrom, J., Kolehmainen, M., Eriksson, J.G., Venojarvi, M., Ilanne-Parikka, P., Keinanen-Kiukaanniemi, S., Tuomilehto, J., and Uusitupa, M. (2011). Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. BMC Med. Genet. 12, 5.Google Scholar
Singh, P., Hoffmann, M., Wolk, R., Shamsuzzaman, A.S., and Somers, V.K. (2007). Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 27, e302–e307.Google Scholar
Soderberg, S., Ahren, B., Stegmayr, B., Johnson, O., Wiklund, P.G., Weinehall, L., Hallmans, G., and Olsson, T. (1999). Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort. Stroke 30, 328–337.Google Scholar
Soderberg, S., Stegmayr, B., Ahlbeck-Glader, C., Slunga-Birgander, L., Ahren, B., and Olsson, T. (2003). High leptin levels are associated with stroke. Cerebrovasc. Dis. 15, 63–69.Google Scholar
Soderberg, S., Stegmayr, B., Stenlund, H., Sjostrom, L.G., Agren, A., Johansson, L., Weinehall, L., and Olsson, T. (2004). Leptin, but not adiponectin, predicts stroke in males. J. Intern. Med. 256, 128–136.Google Scholar
Stott, D.J., Welsh, P., Rumley, A., Robertson, M., Ford, I., Sattar, N., Westendorp, R.G., Jukema, J.W., Cobbe, S.M., and Lowe, G.D. (2009). Adipocytokines and risk of stroke in older people: a nested case-control study. Int. J. Epidemiol. 38, 253–261.Google Scholar
Stumvoll, M., Tschritter, O., Fritsche, A., Staiger, H., Renn, W., Weisser, M., Machicao, F., and Haring, H. (2002). Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 51, 37–41.Google Scholar
Suk, S.H., Sacco, R.L., Boden-Albala, B., Cheun, J.F., Pittman, J.G., Elkind, M.S., Paik, M.C., and S. Northern Manhattan Stroke. (2003). Abdominal obesity and risk of ischemic stroke: the Northern Manhattan Stroke Study. Stroke 34, 1586–1592.Google Scholar
Sweeney, G. (2010). Cardiovascular effects of leptin. Nat. Rev. Cardiol. 7, 22–29.Google Scholar
Takahashi, M., Arita, Y., Yamagata, K., Matsukawa, Y., Okutomi, K., Horie, M., Shimomura, I., Hotta, K., Kuriyama, H., Kihara, S., et al. (2000). Genomic structure and mutations in adipose-specific gene, adiponectin. Int. J. Obes. Relat. Metab. Disord. 24, 861–868.Google Scholar
Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Campfield, L.A., Clark, F.T., Deeds, J., et al. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263–1271.Google Scholar
Tian, L., Luo, N., Klein, R.L., Chung, B.H., Garvey, W.T., and Fu, Y. (2009). Adiponectin reduces lipid accumulation in macrophage foam cells. Atherosclerosis 202, 152–161.Google Scholar
Vaisse, C., Halaas, J.L., Horvath, C.M., Darnell, J.E., Jr., Stoffel, M., and Friedman, J.M. (1996). Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14, 95–97.Google Scholar
Van Gaal, L.F., Mertens, I.L., and De Block, C.E. (2006). Mechanisms linking obesity with cardiovascular disease. Nature 444, 875–880.Google Scholar
Wannamethee, S.G., Shaper, A.G., Whincup, P.H., Lennon, L., and Sattar, N. (2013). Adiposity, adipokines, and risk of incident stroke in older men. Stroke 44, 3–8.Google Scholar
Wong, G.W., Wang, J., Hug, C., Tsao, T.S., and Lodish, H.F. (2004). A family of Acrp30/adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 101, 10302–10307.Google Scholar
Wozniak, S.E., Gee, L.L., Wachtel, M.S., and Frezza, E.E. (2009). Adipose tissue: the new endocrine organ? A review article. Digest. Dis. Sci. 54, 1847–1856.Google Scholar
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001). The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7, 941–946.Google Scholar
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002). Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8, 1288–1295.Google Scholar
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003). Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762–769.Google Scholar
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432.Google Scholar
Zhu, W., Cheng, K.K., Vanhoutte, P.M., Lam, K.S., and Xu, A. (2008). Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin. Sci. (Lond). 114, 361–374.Google Scholar
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