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Reviews in the Neurosciences

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The role of fibroblast growth factors and their receptors in gliomas: the mutations involved

Vasiliki Georgiou
  • Biomedical Sciences Program, Department of Life Sciences, School of Sciences, European University of Cyprus, 6, Diogenis Str, Engomi 2404, Nicosia, Cyprus
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Vasiliki GkretsiORCID iD: http://orcid.org/0000-0002-3671-4078
Published Online: 2018-10-31 | DOI: https://doi.org/10.1515/revneuro-2018-0051


The central nervous system (CNS) comprises of neurons, which are responsible for impulse transmission, and glial cells, which surround neurons providing protection and nutrition. Glial cells are categorized into astrocytes, oligodendrocytes, microglial cells, and ependymal cells. Tumors forming from glial cells are called gliomas, and they are classified accordingly into astrocytomas, oligodendrogliomas, and ependymomas. Gliomas are characterized by high mortality rates and degree of malignancy, heterogeneity, and resistance to treatment. Among the molecular players implicated in glioma pathogenesis are members of the fibroblast growth factor (FGF) superfamily as well as their receptors (FGFRs). In the present study, we provide a review of the literature on the role of FGFs and FGFRs in glioma pathogenesis. We also demonstrate that FGFs, and particularly FGF1 and FGF2, bear a variety of mutations in gliomas, while FGFRs are also crucially involved. In fact, several studies show that in gliomas, FGFRs bear mutations, mainly in the tyrosine kinase domains. Specifically, it appears that FGFR1-TACC1 and FGFR3-TACC3 fusions are common in these receptors. A better understanding of the mutations and the molecular players involved in glioma formation will benefit the scientific community, leading to the development of more effective and innovative therapeutic approaches.

Keywords: fibroblast growth factor; fibroblast growth factor receptor; gliomas; metastasis; mutations


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About the article

Vasiliki Georgiou

Vasiliki Georgiou is a senior-year student at the Biological Sciences Program, Department of Life Sciences, School of Sciences, European University Cyprus.

Vasiliki Gkretsi

Vasiliki Gkretsi is currently an assistant professor at the Biomedical Sciences Program of the Department of Life Sciences at European University Cyprus. She received her Diploma in Biology from the National and Kappodistrean University of Athens, Greece, in 2001 and her PhD from the University of Pittsburgh Medical School, Pittsburgh, USA, in 2006. She then worked as post-doctoral fellow at the BSRC Al. Fleming in Athens, Greece, and between 2009 and 2014, she served as a research assistant professor at the Centre for Research and Technology-Hellas (CE.R.T.H). She is the recipient of numerous awards including the prestigious European Association for the Study of the Liver (EASL) Sheila Sherlock award 2012, which was renewed in 2013. Her research focuses on the study of the role of extracellular matrix, cell adhesion, and the cytoskeleton in cancer progression and metastasis. Her work has been published in 33 peer-reviewed international scientific journals and has received over 500 citations (Scopus, h index=14).

Received: 2018-05-25

Accepted: 2018-08-10

Published Online: 2018-10-31

Citation Information: Reviews in the Neurosciences, 20180051, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2018-0051.

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