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Reviews in the Neurosciences

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The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease

Xin Liu
  • Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410000, China
  • Other articles by this author:
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/ DeRen Hou
  • Corresponding author
  • Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410000, China
  • Email
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/ FangBo Lin
  • Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410000, China
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/ Jing Luo
  • Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410000, China
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/ JingWen Xie
  • Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410000, China
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/ Yan Wang / Yi Tian
Published Online: 2018-12-10 | DOI: https://doi.org/10.1515/revneuro-2018-0056

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease with progressive cognitive impairment. It is the most common type of senile dementia, accounting for 65%–70% of senile dementia [Alzheimer’s Association (2016). 2016 Alzheimer’s disease facts and figures. Alzheimers Dement. 12, 459–509]. At present, the pathogenesis of AD is still unclear. It is considered that β-amyloid deposition, abnormal phosphorylation of tau protein, and neurofibrillary tangles are the basic pathological changes of AD. However, the role of neurovascular unit damage in the pathogenesis of AD has been attracting more and more attention in recent years. The composition of neurovascular unit and the role of neurovascular unit damage in the occurrence and development of AD were reviewed in this paper.

Keywords: Alzheimer’s disease (AD); blood–brain barrier (BBB); neurovascular unit

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About the article

Received: 2018-06-06

Accepted: 2018-08-30

Published Online: 2018-12-10


Citation Information: Reviews in the Neurosciences, 20180056, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2018-0056.

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