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Reviews in the Neurosciences

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Mesenchymal stem cells as a treatment for multiple sclerosis: a focus on experimental animal studies

Ahmed LotfyORCID iD: https://orcid.org/0000-0001-9928-0724 / Nourhan S. Ali
  • Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef 62511, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mai Abdelgawad
  • Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef 62511, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mohamed Salama
  • Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansourah, Ad Daqahliyah, Egypt
  • Institute of Global Health and Human Ecology (IGHHE), American University in Cairo (AUC), Cairo, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-10-12 | DOI: https://doi.org/10.1515/revneuro-2019-0040


Multiple sclerosis (MS) is a progressive and debilitating neurological condition in which the immune system abnormally attacks the myelin sheath insulating the nerves. Mesenchymal stem cells (MSCs) are found in most adult tissues and play a significant systemic role in self-repair. MSCs have promising therapeutic effects in many diseases, such as autoimmune diseases, including MS. MSCs have been tested in MS animal models, such as experimental autoimmune encephalomyelitis. Other studies have combined other agents with MSCs, genetically modified MSCs, or used culture medium from MSCs. In this review, we will summarize these studies and compare the main factors in each study, such as the source of MSCs, the type of animal model, the route of injection, the number of injected cells, and the mechanism of action.

Keywords: EAE; immunomodulation; mesenchymal stem cells; multiple sclerosis


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About the article

Received: 2019-03-24

Accepted: 2019-06-14

Published Online: 2019-10-12

Conflicting interest statement: The authors declare no conflict of interest.

Citation Information: Reviews in the Neurosciences, 20190040, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: https://doi.org/10.1515/revneuro-2019-0040.

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