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Romanian Journal of Internal Medicine

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Acute Lymphocytic Leukemia in Adults. Pathologic Features and Prognosis

Cristina Marinescu
  • Department of Hematology, University Emergency Hospital, Bucharest, Romania
/ Ana-Maria Vladareanu
  • Department of Hematology, University Emergency Hospital, Bucharest, Romania
/ Felicia Mihai
  • Department of Hematology, University Emergency Hospital, Bucharest, Romania
Published Online: 2015-10-07 | DOI: https://doi.org/10.1515/rjim-2015-0004

Abstract

Acute lymphoblastic leukemia (ALL) is a malignant neoplasm of the lymphocyte precursor cells. Among adults it is a relatively rare neoplasm with a curability rate around 30% at 5 years. Currently, the diagnosis and classification of ALL is a multistep procedure that relies on the simultaneous application of multiple techniques that include: cytomorphology, immunophenotype and cytogenetic assays . Some of which have important clinical implications for both diagnosis and predicting response to specific treatment regimens, while the role of others is still to be defined. Over the years, several prognostic factors have been identified and today a risk stratification at diagnosis and during the follow -up is based on the characteristics of the leukemic cells.

Abstract

Leucemia acută limfoblastică (ALL) este o neoplazie malignă a celulelor precursoare limfoide. În rândul adulţilor, este o neoplazie relativ rară cu o rată de curabilitate la 5 ani în jur de 30%. Actualmente, diagnosticul şi clasificarea ALL este o procedură ce presupune mai multe etape care se bazează pe aplicarea simultană de tehnici multiple ce includ: examinări citomorfologice, imunofenotipice şi citogenetice. Unele dintre ele au o implicare clinică importantă atât în diagnostic cât şi în estimarea răspunsului la regimurile de tratament specific, în timp ce rolul celorlalte rămâne să fie definit. De-alungul anilor, au fost identificaţi anumiţi factori de risc, iar astăzi, caracterizarea celulei leucemice stă la baza stratificării riscului la diagnostic şi în timpul evoluţiei bolii.

Keywords: acute lymphoblastic leukaemia; prognostic factors; adults

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About the article

Received: 2015-02-12

Published Online: 2015-10-07

Published in Print: 2015-03-01



Citation Information: Romanian Journal Of Internal Medicine, ISSN (Online) 1220-4749, DOI: https://doi.org/10.1515/rjim-2015-0004. Export Citation

© 2015. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0)

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