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Romanian Journal of Internal Medicine

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Illicit drugs and their impact on cardiovascular pathology

Elisabeta Bădilă
  • “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • “Floreasca” Emergency Clinical Hospital, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mihaela Hostiuc
  • Corresponding author
  • “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • “Floreasca” Emergency Clinical Hospital, Bucharest, Romania
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Emma Weiss
  • “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • “Floreasca” Emergency Clinical Hospital, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Daniela Bartoş
  • “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • “Floreasca” Emergency Clinical Hospital, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-10-14 | DOI: https://doi.org/10.1515/rjim-2015-0029

Abstract

The use of illicit drugs has dramatically increased during the past years. Consequently, the number of presentations at the emergency departments due to the adverse effects of the illicit drugs has also increased. This review discusses the cardiovascular effects of cocaine, opiates and opioids, cannabinoids, amphetamines, methamphetamines and hallucinogens as we consider that it is essential for a clinician to be aware of them and understand their mechanisms in order to optimize the therapeutic management.

Utilizarea drogurilor a crescut alarmant în ultimii ani. Astfel că numărul de prezentări în cadrul departamentelor de primiri urgenţă datorate efectelor adverse ale acestora a crescut şi el. Acest articol tip review discută efectele asupra sistemului cardiovascular al cocainei, opioidelor, canabinoidelor, metamfetaminelor şi halucinogenelor deoarece clinicianul trebuie să le cunoască, să le înţeleagă mecanismul fiziopatologic pentru a îmbunătăţi abordarea terapeutică.

Keywords: illicit drugs; cocaine; cardiovascular effects

REFERENCES

  • 1. www.drugwarfacts.org

  • 2. WILBERT-LAMPEN U, SELIGER C, ZILKER T, ARENDT RM. Cocaine Increases the Endothelial Release of Immunoreactive Endothelin and Its Concentrations in Human Plasma and Urine: Reversal by Coincubation With σ-Receptor Antagonists. Circulation 1998, 98(5):385-390.CrossrefGoogle Scholar

  • 3. MO W, SINGH AK, ARRUDA JAL, DUNEA G. Role of Nitric Oxide in Cocaine-Induced Acute Hypertension. American Journal of Hypertension 1998, 11(6):708-714.CrossrefGoogle Scholar

  • 4. LANGE RA, HILLIS LD. Cardiovascular Complications of Cocaine Use. New England Journal of Medicine 2001, 345(5):351-358.Google Scholar

  • 5. HEESCH CM, WILHELM CR, RISTICH J, ADNANE J, BONTEMPO FA, WAGNER WR. Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans. Heart 2000, 83(6):688-695.Google Scholar

  • 6. RINDER HM, AULT KA, JATLOW PI, KOSTEN TR, SMITH BR. Platelet alpha-granule release in cocaine users. Circulation 1994, 90(3):1162-1167.CrossrefGoogle Scholar

  • 7. SIEGEL AJ, MENDELSON JH, SHOLAR MB, MCDONALD JC, LEWANDROWSKI KB, LEWANDROWSKI EL, LIPINSKA I, RIDKER PM, TOFLER GH. Effect of cocaine usage on C-reactive protein, von Willebrand factor, and fibrinogen. American Journal of Cardiology, 89(9):1133-1135.Google Scholar

  • 8. SCHWARTZ BG, REZKALLA S, KLONER RA. Cardiovascular Effects of Cocaine. Circulation 2010, 122(24):2558-2569.Google Scholar

  • 9. GUO J, GANG H, ZHANG S. Molecular Determinants of Cocaine Block of Human Ether-á-go-go-Related Gene Potassium Channels. Journal of Pharmacology and Experimental Therapeutics 2006, 317(2):865-874.Google Scholar

  • 10. KARCH SB. The pathology of drug abuse. CRC Press Boca Raton; 1996.Google Scholar

  • 11. QURESHI AI, SURI MFK, GUTERMAN LR, HOPKINS LN. Cocaine Use and the Likelihood of Nonfatal Myocardial Infarction and Stroke: Data From the Third National Health and Nutrition Examination Survey. Circulation 2001, 103(4):502-506.Google Scholar

  • 12. HOLLANDER JE, HOFFMAN RS. Cocaine-induced myocardial infarction: An analysis and review of the literature. Journal of Emergency Medicine, 10(2):169-177.CrossrefGoogle Scholar

  • 13. MOHAMAD T, NIRAJ A, FARAH J, OBIDEEN M, BADHEKA A, KONDUR A, THATAI D, AFONSO L. Spectrum of electrocardiographic and angiographic coronary artery disease findings in patients with cocaine-associated myocardial infarction. Coronary artery disease 2009, 20(5):332-336.CrossrefWeb of ScienceGoogle Scholar

  • 14. HOLLANDER JE, HOFFMAN RS, BURSTEIN JL, et al. Cocaine-associated myocardial infarction: Mortality and complications. Archives of Internal Medicine 1995, 155(10):1081-1086.Google Scholar

  • 15. HSUE PY, SALINAS CL, BOLGER AF, BENOWITZ NL, WATERS DD. Acute Aortic Dissection Related to Crack Cocaine. Circulation 2002, 105(13):1592-1595.CrossrefGoogle Scholar

  • 16. DEAN JH, WOZNICKI EM, O'GARA P, MONTGOMERY DG, TRIMARCHI S, MYRMEL T, PYERITZ RE, HARRIS KM, SUZUKI T, BRAVERMAN AC et al. Cocaine-related Aortic Dissection: Lessons from the International Registry of Acute Aortic Dissection. The American Journal of Medicine, 127(9):878-885.Web of ScienceGoogle Scholar

  • 17. EAGLE KA, ISSELBACHER EM, DESANCTIS RW, INVESTIGATORS tIRfAD. Cocaine-Related Aortic Dissection in Perspective. Circulation 2002, 105(13):1529-1530.CrossrefGoogle Scholar

  • 18. CHAMBERS HF, MORRIS DL, TÄUBER MG, MODIN G. Cocaine Use and the Risk for Endocarditis in Intravenous Drug Users. Annals of Internal Medicine 1987, 106(6):833-836.CrossrefGoogle Scholar

  • 19. BRECKLIN CS, GOPANIUK-FOLGA A, KRAVETZ T, SABAH S, SINGH A, ARRUDA JAL, DUNEA G. Prevalence of Hypertension in Chronic Cocaine Users. American Journal of Hypertension 1998, 11(11):1279-1283.CrossrefGoogle Scholar

  • 20. CATRAVAS JD, WATERS IW. Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethality. Journal of Pharmacology and Experimental Therapeutics 1981, 217(2):350-356.Google Scholar

  • 21. BROGAN IIIWC, LANGE RA, KIM AS, MOLITERNO DJ, HILLIS LD. Alleviation of cocaine-induced coronary vasoconstriction by nitroglycerin. Journal of the American College of Cardiology 1991, 18(2):581-586.CrossrefGoogle Scholar

  • 22. SOFUOGLU M, BROWN S, BABB DA, PENTEL PR, HATSUKAMI DK. Carvedilol affects the physiological and behavioral response to smoked cocaine in humans. Drug & Alcohol Dependence, 60(1):69-76.Google Scholar

  • 23. MARTIN-SCHILD S, ALBRIGHT KC, MISRA V, PHILIP M, BARRETO AD, HALLEVI H, GROTTA JC, SAVITZ SI. Intravenous Tissue Plasminogen Activator in Patients with Cocaine-Associated Acute Ischemic Stroke. Stroke; a journal of cerebral circulation 2009, 40(11):3635-3637.Google Scholar

  • 24. AFSHARI R, MAXWELL SRJ, WEBB DJ, BATEMAN DN. Morphine is an arteriolar vasodilator in man. British Journal of Clinical Pharmacology 2009, 67(4):386-393.Web of ScienceGoogle Scholar

  • 25. LIU C, DAI R, YU R, XU J. Morphine preconditioning, cardioprotection and left ventricular remodelling in rabbits. Acta Cardiol 2011, 66(3):341-348.Web of ScienceGoogle Scholar

  • 26. TINTINALLI JE, STAPCZYNSKI JS. Tintinalli's emergency medicine: a comprehensive study guide. McGraw-Hill, New York; 2011.Google Scholar

  • 27. KOHRS R, DURIEUX ME. Ketamine: Teaching an old drug new tricks. Anesthesia & Analgesia 1998, 87(5):1186-1193.Google Scholar

  • 28. SPRUNG MDPJ, SCHUETZ BSSHANNON M, STEWART MDROBERT W, MORAVEC PCHRISTINE S. Effects of ketamine on the contractility of failing and nonfailing human heart muscles in vitro. The Journal of the American Society of Anesthesiologists 1998, 88(5):1202-1210.CrossrefGoogle Scholar

About the article

Received: 2015-05-31

Published Online: 2015-10-14

Published in Print: 2015-09-01


Citation Information: Romanian Journal Of Internal Medicine, ISSN (Online) 1220-4749, DOI: https://doi.org/10.1515/rjim-2015-0029.

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© 2015 Elisabeta Bădilă et al., published by De Gruyter Open. This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License. BY 4.0

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