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Romanian Journal of Internal Medicine

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Glucose Level Estimation in Diabetes Mellitus By Saliva: A Bloodless Revolution

Vidya Kadashetti
  • Corresponding author
  • Oral Pathology & Microbiology, Forensic Odontology School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
  • Email:
/ Rajendra Baad
  • Oral Pathology & Microbiology, Forensic Odontology School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
/ Neelima Malik
  • Oral Pathology & Microbiology, Forensic Odontology School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
/ K.M. Shivakumar
  • Corresponding author
  • Public Health Dentistry School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
  • Email:
/ Nupura Vibhute
  • Oral Pathology & Microbiology, Forensic Odontology School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
/ Uzma Belgaumi
  • Oral Pathology & Microbiology, Forensic Odontology School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
/ Sushma Gugawad
  • Oral Pathology & Microbiology, Forensic Odontology School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
/ R.C. Pramod
  • Oral Pathology & Microbiology, Forensic Odontology School of Dental Sciences, Krishna Institute of Medical Sciences University, Malkapur, Karad-415539, Satara (Dist.), Maharashtra, India
Published Online: 2015-10-14 | DOI: https://doi.org/10.1515/rjim-2015-0032

Abstract

Background. Diabetes mellitus is a massive, growing, silent epidemic that has the potential to cripple health services in all parts of the world. Currently, a diagnosis of diabetes is achieved by evaluating plasma glucose levels. Saliva offers some distinctive advantages. Whole saliva can be collected non-invasively and by individuals with limited training. The present study was aimed to estimate and correlate the plasma and salivary glucose levels in diabetic and non diabetic subjects, with special reference to age.

Method. The study population consisted of three groups: Group 1 consisted of diabetics with BGL>200mg/dl and Group 2 consisted of diabetics with BGL 130-200mg/dl based on their random plasma glucose levels. Group 3 consisted of healthy population as controls with BGL <130 mg/dl. 2 ml of peripheral blood was collected for the estimation of random plasma glucose levels and unstimulated saliva was collected for the estimation of salivary glucose

Results. The salivary glucose levels were significantly higher in group 1 and group 2 diabetics when compared with controls. The salivary glucose levels show a significant correlation with plasma glucose levels between study populations, suggesting that salivary glucose levels can be used as a monitoring tool for predicting glucose level in diabetic patients.

Conclusion. The present study found that estimation of salivary glucose levels can be used as a noninvasive, painless technique for the measurement of diabetic status of a patient in a dental set up.

Introducere. Diabetul zaharat este o patologie gravă cu incidenţa în creştere ce încarcă sistemele de sănătate din toată lumea. În momentul de faţă diagnosticul diabetului se realizează analizând nivelul plasmatic al glucozei. Saliva oferă însă mai multe avantaje. Aceasta poate fi colectată non-invaziv chiar de către pacient. Studiul de faţă a avut ca scop estimarea şi corelarea valorilor salivare ale glucozei comparate cu cele plasmatice.

Metode. Studiul a avut trei grupuri: grupul 1 cu pacienţi cu diabet zaharat cu glicemie >200 mg/dL, grupul 2 cu pacienţi diabetici ce au avut glicemii între 130-200 mg/dL şi grupul 3 cu pacienţi nediabetici (glicemie<130 mg/dL). Pacienţilor le-a fost determinată glicemia şi le-au fost recoltate probe salivare pentru analiza glucozei salivare.

Rezultate. Nivelurile salivare au fost semnificativ statistic mai mari la grupurile 1 şi 2 comparativ cu grupul 3. Glucoza salivară s-a corelat cu glicemia, sugerând că glucoza salivară ar putea fi utilizată drept instrument pentru estimarea glicemiei la diabetici.

Concluzii. Studiul a relevat că evaluarea glucozei salivare poate fi folosită drept un instrument noninvaziv şi nedureros pentru evaluarea pacientului diabetic.

Keywords: glucose; diabetes mellitus; saliva; noninvasive

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About the article

Received: 2015-03-23

Published Online: 2015-10-14

Published in Print: 2015-09-01



Citation Information: Romanian Journal Of Internal Medicine, ISSN (Online) 1220-4749, DOI: https://doi.org/10.1515/rjim-2015-0032. Export Citation

© 2015 Vidya Kadashetti et al., published by De Gruyter Open. This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License. (CC BY 4.0)

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