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Romanian Neurosurgery

The Journal of Romanian Society of Neurosurgery

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2344-4959
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Experimental model of arteriovenous malformation in vitro using biological grafts

Aurelia Mihaela Sandu
  • Corresponding author
  • PhD student, University of Medicine and Pharmacy “Carol Davila”, Bucharest / Fourth Department of Neurosurgery, Emergency Clinical Hospital Bagdasar Arseni, Bucharest
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ A. Giovani
  • PhD student, University of Medicine and Pharmacy “Carol Davila”, Bucharest / Fourth Department of Neurosurgery, Emergency Clinical Hospital Bagdasar Arseni, Bucharest
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ M.R. Gorgan
  • Fourth Department of Neurosurgery, Emergency Clinical Hospital Bagdasar Arseni, Bucharest / University of Medicine and Pharmacy “Carol Davila”, Bucharest
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-06-16 | DOI: https://doi.org/10.1515/romneu-2015-0023

Abstract

Introduction: Brain arteriovenous malformations (AVMs) represent a serious health problem all around the world. Experimental models help to better understand the pathophysiology of these lesions. Experiment: We performed an experimental model of AVM using biological grafts, arteries and veins harvested from chicken wings at the elbow joint. We used 14 vessels and we performed 20 end-to-end anastomoses to create a nidus with a single feeding artery and a single draining vein. The system was irrigated with colored solution. The experiment was done according with law in force regarding experimental research activity. Conclusions: Experimental models allow us to understand the hemodynamics and predict the outcome of brain AVMs in humans. This experimental model is a useful tool in understanding the hemodynamic properties of brain AVMs. It is very useful in vascular anastomosis training

Keywords: arteriovenous malformations; biologic grafts; chicken wings; experimental model

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About the article

Published Online: 2015-06-16

Published in Print: 2015-06-01


Citation Information: Romanian Neurosurgery, ISSN (Online) 2344-4959, ISSN (Print) 1220-8841, DOI: https://doi.org/10.1515/romneu-2015-0023.

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