Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Scientia Agriculturae Bohemica

The Journal of Czech University of Life Sciences Prague

4 Issues per year


CiteScore 2016: 0.78

SCImago Journal Rank (SJR) 2016: 0.398
Source Normalized Impact per Paper (SNIP) 2016: 0.688

Open Access
Online
ISSN
1805-9430
See all formats and pricing
More options …

Garlic Sulfur Compounds Suppress Cancerogenesis and Oxidative Stress: a Review

M. Dvořáková
  • Corresponding author
  • University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Prague, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ I. Weingartová
  • University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ J. Nevoral
  • University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ D. Němeček
  • University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ T. Krejčová
  • University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-07-01 | DOI: https://doi.org/10.1515/sab-2015-0018

Abstract

Garlic has long been considered a food with many health benefits. Several studies have confirmed that sulfur compounds are responsible for the positive effects of garlic on organisms. Garlic acts as an antioxidant by increasing antioxidant enzyme activity, reducing reactive oxygen species generation, and protecting proteins and lipids from oxidation. Garlic suppresses carcinogenesis through several mechanisms: (1) it reduces oxidative stress, and therefore, prevents damage to DNA; (2) it induces apoptosis or cell cycle arrest in cancer cells; and (3) it modifies gene expression through histon acetylation. The positive effects of garlic could be mediated by several mechanisms. It influences signalling pathways of gasotransmitters such as hydrogen sulfide. Garlic enhances hydrogen sulfide production both through its direct release and through an increase in activity of enzymes which produce hydrogen sulfide. Hydrogen sulfide acts as a signalling molecule in various tissues and participates in the regulation of many physiological processes. We can presume that garlic, which is able to release hydrogen sulfide, exhibits effects similar to those of this gasotransmitter.

Keywords: cancer; diallyl disulfide; hydrogen sulfide; reactive oxygen species S-allyl cysteine

References

  • Abe K, Kimura H (1996): The possible role of hydrogen sulfide as an endogenous neuromodulator. The Journal of Neuroscience, 16, 1066-1071.Google Scholar

  • Amagase H (2006): Clarifying the real bioactive constituents of garlic. Journal of Nutrition, 136, 716-725.Google Scholar

  • Antosiewicz J, Herman-Antosiewicz A, Marynowski SW, Singh SV (2006): c-Jun NH2-terminal kinase signaling axis regu - lates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells. Cancer Research, 66, 5379-5386. doi: 10.1158/0008-5472. CAN-06-0356.Google Scholar

  • Apitzcastro R, Cabrera S, Cruz MR, Ledezma E, Jain MK (1983): Effects of garlic extract and of 3 pure components isolated from it on human-platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thrombosis Research, 32, 155-169. doi: 10.1016/0049-3848(83)90027-0.CrossrefGoogle Scholar

  • Arunkumar A, Vijayababu MR, Srinivasan N, Aruldhas MM, Arunakaran J (2006): Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3. Molecular and Cellular Biochemistry, 288, 107-113. doi: 10.1007/s11010-006-9126-6.CrossrefGoogle Scholar

  • Banerjee SK, Maulik M, Manchanda SC, Dinda AK, Das TK, Maulik SK (2001): Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food and Chemical Toxicology, 39, 793-797. doi: 10.1016/S0278-6915(01)00018-7.CrossrefGoogle Scholar

  • Banerjee SK, Maulik M, Mancahanda SC, Dinda AK, Gupta SK, Maulik SK (2002): Dose-dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic. Life Sciences, 70, 1509-1518. doi: 10.1016/S0024-3205(01)01514-4.CrossrefGoogle Scholar

  • Banerjee SK, Mukherjee PK, Maulik SK (2003): Garlic as an antioxidant: the good, the bad and the ugly. Phytotherapy Research, 17, 97-106. doi: 10.1002/ptr.1281.CrossrefGoogle Scholar

  • Batirel HF, Aktan S, Aykut C, Yegen BC, Coskun T (1996): The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C-4 and prostaglandin E(2)) in rat forebrain after ischemia-reperfusion injury. Prostaglandins Leukotrienes and Essential Fatty Acids, 54, 289-292. doi: 10.1016/S0952-3278(96)90061-7.CrossrefGoogle Scholar

  • Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW (2007): Hydrogen sulfide mediates the vasoactivity of garlic. Proceedings of the National Academy of Sciences of the United States of America, 104, 17977-17982. doi: 10.1073/ pnas.0705710104.CrossrefGoogle Scholar

  • Block E, Ahmad S, Jain MK, Crecely RW, Apitzcastro R, Cruz MR (1984): (E,Z)-ajoene - a potent antithrombotic agent from garlic. Journal of the American Chemical Society, 106, 8295-8296. doi: 10.1021/ja00338a049.CrossrefGoogle Scholar

  • Borek C (2001): Antioxidant health effects of aged garlic extract. Journal of Nutrition, 131, 1010-1015.Google Scholar

  • Borrelli F, Capasso R, Izzo AA (2007): Garlic (Allium sativum L.): adverse effects and drug interactions in humans. Molecular Nutrition & Food Research, 51, 1386-1397. doi: 10.1002/mnfr.200700072.CrossrefGoogle Scholar

  • Cervantes MI, Balderas PMD, Gutierrez-Banos JD, Orozco- Ibarra M, Fernandez-Rojas B, Medina-Campos ON, Espinoza- Rojo M, Ruiz-Tachiquin M, Ortiz-Plata A, Salazar MI, Rubio-Osornio M, Castaneda-Saucedo E, Pedraza-Chaverri J, Calzada F, Aguilera P (2013): Comparison of antioxidant activity of hydroethanolic fresh and aged garlic extracts and their effects on cerebral ischemia. Food Chemistry, 140, 343-352. doi: 10.1016/j.foodchem.2013.02.053.CrossrefGoogle Scholar

  • Chuah SC, Moore PK, Zhu YZ (2007): S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway. American Journal of Physiology - Heart and Circulatory Physiology , 293, 2693-2701. doi: 10.1152/ajpheart.00853.2007.CrossrefGoogle Scholar

  • Colin-Gonzalez AL, Santana RA, Silva-Islas CA, Chanez- Cardenas ME, Santamaria A, Maldonado PD (2012): The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Oxidative Medicine and Cellular Longevity, ID 907162. doi: 10.1155/2012/907162.CrossrefGoogle Scholar

  • Corzo-Martinez M, Corzo N, Villamiel M (2007): Biological properties of onions and garlic. Trends in Food Science and Technology, 18, 609-625.Google Scholar

  • Das I, Khan NS, Sooranna SR (1995): Nitric-oxide synthase activation is a unique mechanism of garlic action. Biochemical Society Transactions, 23, 136-136.Google Scholar

  • Dion ME, Milner JA (1997): Garlic inhibits cytochrome P450 2E1 mediated chlorzoxazone metabolism. Faseb Journal, 11, 2144-2144.Google Scholar

  • Druesne-Pecollo N, Chaumontet C, Pagniez A, Vaugelade P, Bruneau A, Thomas M, Cherbuy C, Duee PH, Martel P (2007): In vivo treatment by diallyl disulfide increases histone acetylation in rat colonocytes. Biochemical and Biophysical Research Communications, 354, 140-147. doi: 10.1016/j.bbrc.2006.12.158.CrossrefGoogle Scholar

  • Egenschwind C, Eckard R, Kemper FH (1992): Metabolism of garlic constituents in the isolated perfused-rat-liver. Planta Medica, 58, 301-305.Google Scholar

  • Filomeni G, Aquilano K, Rotilio G, Ciriolo MR (2003): Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer Research, 63, 5940-5949.Google Scholar

  • Freeman F, Kodera Y (1995): Garlic chemistry - stability of S-(2-propenyl) 2-propene-1-sulfinothiolate (allicin) in blood, solvents, and simulated physiological fluids. Journal of Agricultural and Food Chemistry, 43, 2332-2338. doi: 10.1021/ jf00057a004.CrossrefGoogle Scholar

  • Fukao T, Hosono T, Misawa S, Seki T, Ariga T (2004): The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food and Chemical Toxicology, 42, 743-749. doi: 10.1016/j. fct.2003.12.010.CrossrefGoogle Scholar

  • Gonen A, Harats D, Rabinkov A, Miron T, Mirelman D, Wilchek M, Weiner L, Ulman E, Levkovitz H, Ben-Shushan D, Shaish A (2005): The antiatherogenic effect of allicin: possible mode of action. Pathobiology, 72, 325-334. doi: 10.1159/000091330.CrossrefGoogle Scholar

  • Gorinstein S, Jastrzebski Z, Namiesnik J, Leontowicz H, Leontowicz M, Trakhtenberg S (2007): The atherosclerotic heart disease and protecting properties of garlic: contemporary data. Molecular Nutrition & Food Research, 51, 1365-1381. doi: 10.1002/mnfr.200700064.CrossrefGoogle Scholar

  • Guyonnet D, Siess MH, Le Bon AM, Suschetet M (1999): Modulation of phase II enzymes by organosulfur compounds from allium vegetables in rat tissues. Toxicology and Applied Pharmacology, 154, 50-58. doi: 10.1006/taap.1998.8574.CrossrefGoogle Scholar

  • Herman-Antosiewicz A, Singh SV (2005): Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells. Journal of Biological Chemistry, 280, 28519-28528. doi: 10.1074/jbc.M501443200.CrossrefGoogle Scholar

  • Herman-Antosiewicz A, Stan SD, Hahm ER, Xiao D, Singh SV (2007): Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic. Molecular Cancer Therapeutics, 6, 1249-1261. doi: 10.1158/1535-7163.MCT-06-0477.CrossrefGoogle Scholar

  • Hosono T, Fukao T, Ogihara J, Ito Y, Shiba H, Seki T, Ariga T (2005): Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. Journal of Biological Chemistry, 280, 41487-41493. doi: 10.1074/jbc. M507127200.CrossrefGoogle Scholar

  • Iciek M, Kwiecien I, Wlodek L (2009): Biological properties of garlic and garlic-derived organosulfur compounds. Environmental and Molecular Mutagenesis, 50, 247-265. doi: 10.1002/em.20474.CrossrefGoogle Scholar

  • Ide N, Lau BHS (2001): Garlic compounds minimize intracel - lular oxidative stress and inhibit nuclear factor-kappa B activation. Journal of Nutrition, 131, 1020-1026.Google Scholar

  • Ide N, Nelson AB, Lau BHS (1997): Aged garlic extract and its constituents inhibit Cu2+-induced oxidative modification of low density lipoprotein. Planta Medica, 63, 263-264. doi: 10.1055/s-2006-957668.CrossrefGoogle Scholar

  • Insko MA, Deckwerth TL, Hill P, Toombs CF, Szabo C (2009): Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide. British Journal of Pharmacology, 157, 944-951. doi: 10.1111/j.1476-5381.2009.00248.x.CrossrefGoogle Scholar

  • Joseph PK, Rao KR, Sundaresh CS (1989): Toxic effects of garlic extract and garlic oil in rats. Indian Journal of Experimental Biology, 27, 977-979.Google Scholar

  • Karmakar S, Banik NL, Patel SJ, Ray SK (2007): Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis, 12, 671-684. doi: 10.1007/s10495-006-0024-x.CrossrefGoogle Scholar

  • Khanum F, Anilakumar KR, Viswanathan KR (2004): Anticarcinogenic properties of garlic: a review. Critical Reviews in Food Science and Nutrition, 44, 479-488. doi: 10.1080/10408690490886700.CrossrefGoogle Scholar

  • Kim YA, Xiao D, Xiao H, Powolny AA, Lew KL, Reilly ML, Zeng Y, Wang Z, Singh SV (2007): Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak. Molecular Cancer Therapeutics, 6, 1599-1609. doi: 10.1158/1535-7163.MCT-06-0754.PubMedCrossrefGoogle Scholar

  • Knowles LM, Milner JA (2000): Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation. Carcinogenesis, 21, 1129-1134. doi: 10.1093/carcin/21.6.1129.CrossrefGoogle Scholar

  • Lachmann G, Lorenz D, Radeck W, Steiper M (1994): Studies on the pharmacokinetics of the S-35 labeled garlic constituents alliin, allicin, and vinyldithiines. Arzneimittelforschung, 44, 734-743.Google Scholar

  • Lamm DL, Riggs DR (2001): Enhanced immunocompetence by garlic: role in bladder cancer and other malignancies. Journal of Nutrition, 131, 1067-1070.Google Scholar

  • Lanzotti V (2006): The analysis of onion and garlic. Journal of Chromatography A, 1112, 3-22. doi: 10.1016/j.chroma. 2005.12.016.CrossrefGoogle Scholar

  • Lau BHS (2001): Suppression of LDL oxidation by garlic. Journal of Nutrition, 131, 985-988.Google Scholar

  • Lau BHS, Lam F, Wangcheng R (1987): Effect of an odormodified garlic preparation on blood lipids. Nutrition Research, 7, 139-149. doi: 10.1016/S0271-5317(87)80026-X.CrossrefGoogle Scholar

  • Lawson LD, Hughes BG (1992): Characterization of the forma - tion of allicin and other thiosulfinates from garlic. Planta Medica, 58, 345-350. doi: 10.1055/s-2006-961482.CrossrefGoogle Scholar

  • Lea MA, Randolph VM, Patel M (1999): Increased acetylation of histones induced by diallyl disulfide and structurally related molecules. International Journal of Oncology, 15, 347-352.PubMedGoogle Scholar

  • Lea MA, Rasheed M, Randolph VM, Khan F, Shareef A, desBordes C (2002): Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine. Nutrition and Cancer - an International Journal, 43, 90-102. doi: 10.1207/S15327914NC431_11.CrossrefGoogle Scholar

  • Li M, Min JM, Cui JR, Zhang LH, Wang K, Valette A, Davrinche C, Wright M, Leung-Tack J (2002): Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage. Nutrition and Cancer - an International Journal, 42, 241-247. doi: 10.1207/S15327914NC422_14.CrossrefGoogle Scholar

  • Ma KU, Liu Y, Zhu Q, Liu CH, Duan JL, Tan BKH, Zhu YZ (2011): H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti- cancer effect of endogenous H2S? PLOS ONE, 6:e20525. doi: 10.1371/journal.pone.0020525.CrossrefGoogle Scholar

  • Matsuura N, Miyamae Y, Yamane K, Nagao Y, Hamada Y, Kawaguchi N, Katsuki T, Hirata K, Sumi SI, Ishikawa H (2006): Aged garlic extract inhibits angiogenesis and proliferation of colorectal carcinoma cells. Journal of Nutrition, 136, 842-846.Google Scholar

  • Mousa AS, Mousa SA (2005): Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutrition and Cancer - an International Journal, 53, 104-110. doi: 10.1207/s15327914nc5301_12.Google Scholar

  • Nakagawa H, Tsuta K, Kiuchi K, Senzaki H, Tanaka K, Hioki K, Tsubura A (2001): Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. Carcinogenesis, 22, 891-897.PubMedCrossrefGoogle Scholar

  • Park EK, Kwon KB, Park KI, Park BH, Jhee EC (2002): Role of Ca2+ in diallyl disulfide-induced apoptotic cell death of HCT-15 cells. Experimental and Molecular Medicine, 34, 250-257. doi: 10.1038/emm.2002.35. CrossrefGoogle Scholar

  • Perchellet JP, Perchellet EM, Belman S (1990): Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of 2 tumor-promotion stages by garlic and onbion oils. Nutrition and Cancer - an International Journal, 14, 183-193. doi: 10.1080/01635589009514093.CrossrefGoogle Scholar

  • Pinto JT, Krasnikov BF, Coopert AJL (2006): Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives. Journal of Nutrition, 136, 835-841.Google Scholar

  • Prasad K, Laxdal VA, Yu M, Raney BL (1996): Evaluation of hydroxyl radical-scavenging property of garlic. Molecular and Cellular Biochemistry, 154, 55-63. doi: 10.1007/ BF00248461.CrossrefGoogle Scholar

  • Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L (2000): S-allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochimica et Biophysica Acta - Molecular Cell Research, 1499, 144-153. doi: 10.1016/S0167-4889(00)00119-1.CrossrefGoogle Scholar

  • Rosen RT, Hiserodt RD, Fukuda EK, Ruiz RJ, Zhou ZY , Lech J, Rosen SL, Hartman TG (2001): Determination of allicin, S-allylcysteine and volatile metabolites of garlic in breath, plasma or simulated gastric fluids. Journal of Nutrition, 131, 968-971.Google Scholar

  • Schaffer EM, Liu JZ, Green J, Dangler CA, Milner JA (1996): Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis. Cancer Letters, 102, 199-204. doi: 10.1016/0304-3835(96)04160-2.CrossrefGoogle Scholar

  • Singh SV, Mohan R, Agarwal R, Benson PJ, Hu X, Rudy MA, Xia H, Katoh A, Srivastava SK, Mukhtar H, Gupta V, Zaren HA (1996): Novel anti-carcinogenic activity of an organosulfide from garlic: inhibition of H-RAS oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21(H-ras) processing. Biochemical and Biophysical Research Communications, 225, 660-665. doi: 10.1006/bbrc.1996.1226.CrossrefGoogle Scholar

  • Sooranna SR, Hirani J, Das I (1995): Garlic can induce both GTP cyclohydrolase and nitric oxide synthase activity in choriocarcinoma cells. Biochemical Society Transactions, 23, 543.CrossrefGoogle Scholar

  • Sparnins VL, Barany G, Wattenberg LW (1988): Effects of organosulfur compounds of garlic and onions on benzo(a) pyrene-induced neoplasia and glutatione S-transferase activity in the mouse. Carcinogenesis, 9, 131-134. doi: 10.1093/ carcin/9.1.131.CrossrefGoogle Scholar

  • Srilatha B, Adaikan PG, Li L, Moore PK (2007): Hydrogen sulfide: a novel gasotransmitter facilitates erectile function. The Journal of Sexual Medicine, 4, 1304-1311.PubMedCrossrefGoogle Scholar

  • Steare SE, Yellon DM (1995): The potential for endogenous myocardial antioxidants to protect the myocardium against ischemia-reperfusion injury -refreshing the parts exogenous antioxidants cannot reach. Journal of Molecular and Cellular Cardiology, 27, 65-74. doi: 10.1016/S0022-2828(08)80008-9.CrossrefGoogle Scholar

  • Steiner M, Li W (2001): Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. Journal of Nutrition, 131, 980-984.Google Scholar

  • Sundaram SG, Milner JA (1996): Diallyl disulfide suppresses the growth of human colon tumor cell xenografts in athymic nude mice. Journal of Nutrition, 126, 1355-1361.Google Scholar

  • Suzui N, Sugie S, Rahman KMW, Ohnishi M, Yoshimi N, Wakabayashi K, Mori H (1997): Inhibitory effects of diallyl disulfide or aspirin on 2-amino-1-methyl-6-phenylimidazo 4,5-b pyridine-induced mammary carcinogenesis in rats. Japanese Journal of Cancer Research, 88, 705-711.Google Scholar

  • Takahashi S, Hakoi K, Yada H, Hirose M, Ito N, Fukushima S (1992): Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and rectal carcinogenesis in rats. Carcinogenesis, 13, 1513-1518. doi: 10.1093/carcin/13.9.1513.CrossrefGoogle Scholar

  • Tanaka S, Haruma K, Yoshihara M, Kajiyama G, Kira K, Amagase H, Chayama K (2006): Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. Journal of Nutrition, 136, 821-826.Google Scholar

  • Wang R (2002): Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter? The FASEB Journal, 16, 1792-1798. doi: 10.1096/fj.02-0211hyp.CrossrefGoogle Scholar

  • Wang Q, Wang XL, Liu HR, Rose P, Zhu YZ (2010): Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H2S production. Antioxidants and Redox Signaling, 12, 1155-1165. doi: 10.1089/ ars.2009.2947.PubMedCrossrefGoogle Scholar

  • Wargovich MJ, Woods C, Eng VWS, Stephens LC, Gray K (1988): Chemoprevention of N-nitrosomethylbenzylamineinduced esophageal cancer in rats by the naturally-occuring thioether, diallyl sulfide. Cancer Research, 48, 6872-6875.Google Scholar

  • Wu CC, Chung JG, Tsai SJ, Yang JH, Sheen LY (2004): Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells. Food and Chemical Toxicology, 42, 1937-1947. doi: 10.1016/j. fct.2004.07.008.CrossrefGoogle Scholar

  • Xiao D, Choi S, Johnson DE, Vogel VG, Johnson CS, Trump DL, Lee YJ, Singh SV (2004): Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene, 23, 5594-5606. doi: 10.1038/sj.onc.1207747.PubMedCrossrefGoogle Scholar

  • Xiao D, Herman-Antosiewicz A, Antosiewicz J, Xiao H, Brisson M, Lazo JS, Singh SV (2005): Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C. Oncogene, 24, 6256-6268. doi: 10.1038/sj.onc.1208759.CrossrefGoogle Scholar

  • Xiao D, Lew KL, Kim YA, Zeng Y, Hahm ER, Dhir R, Singh SV (2006a): Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction. Clinical Cancer Research, 12, 6836-6843. doi: 10.1158/1078-0432.CCR-06-1273.CrossrefGoogle Scholar

  • Xu B, Monsarrat B, Gairin JE, Girbal-Neuhauser E (2004): Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells. Fundamental and Clinical Pharmacology, 18, 171-180. doi: 10.1111/j.1472-8206.2004.00219.x.CrossrefGoogle Scholar

  • Yuan JP, Wang GH, Ling H, Su Q, Yang YH, Song Y, Tang RJ, Liu Y, Huang C (2004): Diallyl disulfide-induced G2/M arrest of human gastric cancer MGC803 cells involves activation of p38 MAP kinase pathways. World Journal of Gastroenterology, 10, 2731-2734.Google Scholar

  • Zhang YW, Wen J, Xiao JB, Tallbot SG, Li GC, Xu M (2006): Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells. Archives of Pharmacal Research, 29, 1125-1131. doi: 10.1007/BF02969303.CrossrefGoogle Scholar

  • Zhao W, Zhang J, Lu Y, Wang R (2001): The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. The EMBO Journal, 20, 6008-6016. Google Scholar

About the article

Received: 2014-01-25

Accepted: 2015-05-28

Published Online: 2015-07-01

Published in Print: 2015-06-01


Citation Information: Scientia Agriculturae Bohemica, ISSN (Online) 1805-9430, ISSN (Print) 1211-3174, DOI: https://doi.org/10.1515/sab-2015-0018.

Export Citation

© 2015. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
V. Sloup, I. Jankovská, I. Langrová, M. Štolcová, S. Sloup, S. Nechybová, and P. Peřinková
Scientia Agriculturae Bohemica, 2016, Volume 47, Number 4
[2]
Mohamed Balaha, Samah Kandeel, and Walaa Elwan
Life Sciences, 2016, Volume 146, Page 40

Comments (0)

Please log in or register to comment.
Log in