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Statistical Applications in Genetics and Molecular Biology

Editor-in-Chief: Stumpf, Michael P.H.

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Volume 4, Issue 1 (Jul 2005)


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Error Distribution for Gene Expression Data

Elizabeth Purdom / Susan P Holmes
Published Online: 2005-07-12 | DOI: https://doi.org/10.2202/1544-6115.1070

We present a new instance of Laplace's second Law of Errors and show how it can be used in the analysis of data from microarray experiments. This error distribution is shown to fit microarray expression data much better than a normal distribution. The use of this distribution in a parametric bootstrap leads to more powerful tests as we show that the t-test is conservative in this setting. We propose a biological explanations for this distribution based on the Pareto distribution of the variables used to compute the log ratios.

Keywords: Assymetric Laplace; Gene Expression; Error Distribution; Laplace

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Published Online: 2005-07-12

Citation Information: Statistical Applications in Genetics and Molecular Biology, ISSN (Online) 1544-6115, ISSN (Print) 2194-6302, DOI: https://doi.org/10.2202/1544-6115.1070.

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