Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Statistical Applications in Genetics and Molecular Biology

Editor-in-Chief: Stumpf, Michael P.H.

6 Issues per year


IMPACT FACTOR 2016: 0.646
5-year IMPACT FACTOR: 1.191

CiteScore 2016: 0.94

SCImago Journal Rank (SJR) 2016: 0.625
Source Normalized Impact per Paper (SNIP) 2016: 0.596

Mathematical Citation Quotient (MCQ) 2016: 0.06

Online
ISSN
1544-6115
See all formats and pricing
More options …
Volume 4, Issue 1 (Jul 2005)

Issues

Volume 10 (2011)

Volume 9 (2010)

Volume 6 (2007)

Volume 5 (2006)

Volume 4 (2005)

Volume 2 (2003)

Volume 1 (2002)

Error Distribution for Gene Expression Data

Elizabeth Purdom / Susan P Holmes
Published Online: 2005-07-12 | DOI: https://doi.org/10.2202/1544-6115.1070

We present a new instance of Laplace's second Law of Errors and show how it can be used in the analysis of data from microarray experiments. This error distribution is shown to fit microarray expression data much better than a normal distribution. The use of this distribution in a parametric bootstrap leads to more powerful tests as we show that the t-test is conservative in this setting. We propose a biological explanations for this distribution based on the Pareto distribution of the variables used to compute the log ratios.

Keywords: Assymetric Laplace; Gene Expression; Error Distribution; Laplace

About the article

Published Online: 2005-07-12


Citation Information: Statistical Applications in Genetics and Molecular Biology, ISSN (Online) 1544-6115, ISSN (Print) 2194-6302, DOI: https://doi.org/10.2202/1544-6115.1070.

Export Citation

©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
A.-L. Boulesteix, C. Strobl, T. Augustin, and M. Daumer
Cancer Informatics, 2008, Volume 6, Page CIN.S408
[2]
Jesse M. Engreitz, Bernie J. Daigle, Jonathan J. Marshall, and Russ B. Altman
Journal of Biomedical Informatics, 2010, Volume 43, Number 6, Page 932
[3]
F. Napolitano, G. Raiconi, R. Tagliaferri, A. Ciaramella, A. Staiano, and G. Miele
International Journal of Approximate Reasoning, 2008, Volume 47, Number 1, Page 70
[4]
Samuel McDaniel, Jessica Minnier, Rebecca A. Betensky, Gayatry Mohapatra, Yiping Shen, James F. Gusella, David N. Louis, and Tianxi Cai
Statistics in Biosciences, 2010, Volume 2, Number 2, Page 120
[5]
Soheila Khodakarim, Seyyed Mohammad Tabatabaei, and Hamid AlaviMajd
Gene, 2014, Volume 552, Number 1, Page 18
[6]
Edward W.J. Wallace, Edoardo M. Airoldi, and D. Allan Drummond
Molecular Biology and Evolution, 2013, Volume 30, Number 6, Page 1438
[7]
Brunilda Balliu, Roula Tsonaka, Stefan Boehringer, and Jeanine Houwing-Duistermaat
Genetic Epidemiology, 2015, Volume 39, Number 3, Page 156
[8]
Arthur C. Tsai, Michelle Liou, Maria Simak, and Philip E. Cheng
Computational Statistics & Data Analysis, 2017, Volume 115, Page 250
[9]
Filidor Vilca, Mariana Rodrigues-Motta, and Víctor Leiva
Journal of Applied Statistics, 2013, Volume 40, Number 11, Page 2354
[10]
Hamid Alavi-Majd, Soheila Khodakarim, Farid Zayeri, Mostafa Rezaei-Tavirani, Seyyed Mohammad Tabatabaei, and Maryam Heydarpour-Meymeh
Gene, 2014, Volume 534, Number 2, Page 383
[11]
Joaquim Casellas, Luis Varona, and Timothy Ravasi
PLoS ONE, 2012, Volume 7, Number 6, Page e38919
[12]
Lan Wang, Bo Peng, and Runze Li
Journal of the American Statistical Association, 2015, Volume 110, Number 512, Page 1658
[13]
C. Z. W. Hassell Sweatman, G. C. Wake, A. B. Pleasants, C. A. McLean, and A. M. Sheppard
ISRN Probability and Statistics, 2013, Volume 2013, Page 1
[14]
Haim Shore
Quality and Reliability Engineering International, 2014, Volume 30, Number 8, Page 1233
[15]
Nicola Lama, Patrizia Boracchi, and Elia Biganzoli
Computational Statistics & Data Analysis, 2009, Volume 53, Number 5, Page 1906
[16]
Diego Salas-Gonzalez, Ercan E. Kuruoglu, and Diego P. Ruiz
Computational Statistics & Data Analysis, 2009, Volume 53, Number 5, Page 1535

Comments (0)

Please log in or register to comment.
Log in