Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Statistical Applications in Genetics and Molecular Biology

Editor-in-Chief: Sanguinetti, Guido

6 Issues per year

IMPACT FACTOR 2017: 0.812
5-year IMPACT FACTOR: 1.104

CiteScore 2017: 0.86

SCImago Journal Rank (SJR) 2017: 0.456
Source Normalized Impact per Paper (SNIP) 2017: 0.527

Mathematical Citation Quotient (MCQ) 2017: 0.04

See all formats and pricing
More options …
Volume 6, Issue 1


Volume 10 (2011)

Volume 9 (2010)

Volume 6 (2007)

Volume 5 (2006)

Volume 4 (2005)

Volume 2 (2003)

Volume 1 (2002)

An Expectation Maximization Approach to Estimate Malaria Haplotype Frequencies in Multiply Infected Children

Xiaohong Li / Andrea S Foulkes / Recai M. Yucel / Stephen M. Rich
Published Online: 2007-11-19 | DOI: https://doi.org/10.2202/1544-6115.1321

Characterizing genetic variability in the human pathogenic Plasmodium species, the group of parasites that cause Malaria, may have broad global health implications. Specifically, discerning the combinations of mutations that lead to viable parasites and the population level frequencies of these clonal sequences will allow for targeted vaccine development and individualized treatment choices. This presents an analytical challenge, however, since haplotypic phase (i.e. the alignment of bases on a single DNA strand) is generally unobservable in multiply infected individuals. This manuscript describes an expectation maximization (EM) approach to maximum likelihood estimation of haplotype frequencies in this missing data setting. The approach is applied to a cohort of N=341 malaria infected children in Uganda, Cameroon and Sudan to characterize regional differences. A simulation study is also presented to characterize method performance and assess sensitivity to distributional assumptions.

Keywords: expectation maximization; clones; haplotypes; malaria parasite

About the article

Published Online: 2007-11-19

Citation Information: Statistical Applications in Genetics and Molecular Biology, Volume 6, Issue 1, ISSN (Online) 1544-6115, ISSN (Print) 2194-6302, DOI: https://doi.org/10.2202/1544-6115.1321.

Export Citation

©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Leonore Wigger, Julia E. Vogt, and Volker Roth
Statistics in Medicine, 2013, Volume 32, Number 21, Page 3737
D. Kessner, T. L. Turner, and J. Novembre
Molecular Biology and Evolution, 2013, Volume 30, Number 5, Page 1145

Comments (0)

Please log in or register to comment.
Log in