Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Statistical Applications in Genetics and Molecular Biology

Editor-in-Chief: Stumpf, Michael P.H.

6 Issues per year

IMPACT FACTOR 2016: 0.646
5-year IMPACT FACTOR: 1.191

CiteScore 2016: 0.94

SCImago Journal Rank (SJR) 2016: 0.625
Source Normalized Impact per Paper (SNIP) 2016: 0.596

Mathematical Citation Quotient (MCQ) 2016: 0.06

See all formats and pricing
More options …
Volume 9, Issue 1 (Feb 2010)


Volume 10 (2011)

Volume 9 (2010)

Volume 6 (2007)

Volume 5 (2006)

Volume 4 (2005)

Volume 2 (2003)

Volume 1 (2002)

Weighted-LASSO for Structured Network Inference from Time Course Data

Camille Charbonnier / Julien Chiquet / Christophe Ambroise
Published Online: 2010-02-01 | DOI: https://doi.org/10.2202/1544-6115.1519

We present a weighted-LASSO method to infer the parameters of a first-order vector auto-regressive model that describes time course expression data generated by directed gene-to-gene regulation networks. These networks are assumed to own prior internal structures of connectivity which drive the inference method. This prior structure can be either derived from prior biological knowledge or inferred by the method itself. We illustrate the performance of this structure-based penalization both on synthetic data and on two canonical regulatory networks (the yeast cell cycle regulation network and the E. coli S.O.S. DNA repair network).

Keywords: biological networks; vector auto-regressive model; LASSO

About the article

Published Online: 2010-02-01

Citation Information: Statistical Applications in Genetics and Molecular Biology, ISSN (Online) 1544-6115, DOI: https://doi.org/10.2202/1544-6115.1519.

Export Citation

©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Christopher J. Quinn, Ali Pinar, and Negar Kiyavash
IEEE Transactions on Molecular, Biological and Multi-Scale Communications, 2017, Volume 3, Number 2, Page 79
Miguel Lopes, Burak Kutlu, Michela Miani, Claus H. Bang-Berthelsen, Joachim Størling, Flemming Pociot, Nathan Goodman, Lee Hood, Nils Welsh, Gianluca Bontempi, and Decio L. Eizirik
Genomics, 2014, Volume 103, Number 4, Page 264
Ling-Hong Hung, Daniel Kristiyanto, Sung Bong Lee, Ka Yee Yeung, and Lennart Martens
PLOS ONE, 2016, Volume 11, Number 4, Page e0152686
Xiaodian Sun, Fang Hu, Shuang Wu, Xing Qiu, Patrice Linel, and Hulin Wu
Infectious Disease Modelling, 2016, Volume 1, Number 1, Page 52
Aurélie Pirayre, Camille Couprie, Frédérique Bidard, Laurent Duval, and Jean-Christophe Pesquet
BMC Bioinformatics, 2015, Volume 16, Number 1

Comments (0)

Please log in or register to comment.
Log in