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Licensed Unlicensed Requires Authentication Published by De Gruyter December 15, 2018

False discovery control for penalized variable selections with high-dimensional covariates

  • Kevin He EMAIL logo , Xiang Zhou , Hui Jiang , Xiaoquan Wen and Yi Li

Abstract

Modern bio-technologies have produced a vast amount of high-throughput data with the number of predictors much exceeding the sample size. Penalized variable selection has emerged as a powerful and efficient dimension reduction tool. However, control of false discoveries (i.e. inclusion of irrelevant variables) for penalized high-dimensional variable selection presents serious challenges. To effectively control the fraction of false discoveries for penalized variable selections, we propose a false discovery controlling procedure. The proposed method is general and flexible, and can work with a broad class of variable selection algorithms, not only for linear regressions, but also for generalized linear models and survival analysis.

Award Identifier / Grant number: 11528102

Funding statement: The authors thank Dr. Kirsten Herold at the UM-SPH Writing lab for her helpful suggestions. Chinese Natural Science Foundation, Grant Number: 11528102.

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Supplementary Material

The online version of this article offers supplementary material (DOI: https://doi.org/10.1515/sagmb-2018-0038).


Published Online: 2018-12-15

©2018 Walter de Gruyter GmbH, Berlin/Boston

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