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Scandinavian Journal of Pain

Official Journal of the Scandinavian Association for the Study of Pain

Editor-in-Chief: Breivik, Harald

4 Issues per year


CiteScore 2017: 0.84

SCImago Journal Rank (SJR) 2017: 0.401
Source Normalized Impact per Paper (SNIP) 2017: 0.452

Online
ISSN
1877-8879
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Volume 12, Issue 1

The impact of opioid treatment on regional gastrointestinal transit

D. Jørgensen
  • Corresponding author
  • Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ J.L. Poulsen
  • Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
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  • De Gruyter OnlineGoogle Scholar
/ A.E. Olesen
  • Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
  • Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
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  • De Gruyter OnlineGoogle Scholar
/ C. Brock
  • Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
  • Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
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/ T.H. Sandberg
  • Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
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/ K. Krogh
  • Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
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/ A.M. Drewes
  • Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
  • Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Published Online: 2016-07-01 | DOI: https://doi.org/10.1016/j.sjpain.2016.05.029

Abstract

Aims

To employ a human experimental model of opioid-induced bowel dysfunction (OIBD) in healthy volunteers, and evaluate the impact of opioid treatment compared to placebo on gastrointestinal (GI) symptoms and motility, assessed by questionnaires and regional GI transit times.

Methods

Twenty-five healthy males were randomly assigned to oxycodone or placebo for five days in a double-blind, crossover design. Adverse GI effects were measured with bowel function index, gastrointestinal symptom rating scale, patient assessment of constipation symptoms questionnaire, and bristol stool form scale. Regional GI transit times were determined using the 3D-Transit system and segmental colonic transit times were determined using a custom Matlab® graphical user interface.

Results

GI symptom scores increased significantly across all applied questionnaires during opioid treatment. Oxycodone increased median total GI transit time from 22.2 to 43.9 h (P< 0.01), segmental transit times in the cecum and ascending colon from 5.7 to 9.9 h (P<0.05), rectosigmoid transit time from 2.7 to 9.0 h (P<0.05), and colorectal transit time from 18.6 to 38.6 h (P<0.01). No association between questionnaire scores and segmental transit times were detected.

Conclusions

Self-assessed adverse GI effects and increased GI transit times in different segments were induced during oxycodone treatment. This detailed information about segmental changes in motility has great potential for future interventional head-to-head trials of different laxative regimes for prevention and treatment of OIBD.

About the article

Published Online: 2016-07-01

Published in Print: 2016-07-01


Citation Information: Scandinavian Journal of Pain, Volume 12, Issue 1, Pages 126–126, ISSN (Online) 1877-8879, ISSN (Print) 1877-8860, DOI: https://doi.org/10.1016/j.sjpain.2016.05.029.

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