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About the article
Published Online: 2016-10-01
Published in Print: 2016-10-01
Disclosures: This work was supported by Merck & Co., Inc., Kenilworth, NJ, USA.
Conflict of interest: Relationships relevant to this manuscript: P.M. Peloso, D. F. Gates, W. L. Straus, Z. Popmihajlov are currently or were employees of Merck & Co., Inc. and may own stock/stock options in Merck & Co., Inc. W-J Chen, H-Y Lin were investigators for the study, which was sponsored by Merck & Co., Inc. R.A. Moore has no competing interests related to this work.
Author contributions: All authors discussed the results and commented on the results and manuscript. P.M. Peloso, W-J Chen, H-Y Lin, D.F. Gates, W.L. Straus, Z. Popmihajlov and R.A. Moore made substantial contributions to: (1) study conception and design and analysis and interpretation of data; (2) drafting the article and revising it critically for important intellectual content; and (3) final approval of the version to be published.
Ethical issues: The study was conducted in 16 hospitals in Taiwan and the protocol was not registered. The study protocol and procedures were approved by the respective Ethics Review Boards. Written consent was obtained prior to subjects undergoing any study procedures (16).