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Scandinavian Journal of Pain

Official Journal of the Scandinavian Association for the Study of Pain

Editor-in-Chief: Breivik, Harald


CiteScore 2018: 0.85

SCImago Journal Rank (SJR) 2018: 0.494
Source Normalized Impact per Paper (SNIP) 2018: 0.427

Online
ISSN
1877-8879
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Volume 16, Issue 1

Issues

Social stress, epigenetic changes and pain

M.B. Eriksen
  • The National Institute of Occupational Health, Oslo, Norway
  • Department of Biosciences, University of Oslo, Oslo, Norway
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ D.P. Jacobsen
  • The National Institute of Occupational Health, Oslo, Norway
  • Department of Biosciences, University of Oslo, Oslo, Norway
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ J. Gjerstad
  • The National Institute of Occupational Health, Oslo, Norway
  • Department of Biosciences, University of Oslo, Oslo, Norway
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-07-01 | DOI: https://doi.org/10.1016/j.sjpain.2017.04.017

Abstract

Aims

Bullying is a prevalent issue in society, with adverse effects ranging from psychological symptoms to somatic ailments like chronic pain. The purpose of this study was to generate new knowledge about the underlying mechanisms behind this association. Using an animal model, we investigated the changes in microRNA expression in plasma, in the pituitary gland and the adrenal gland following social stress.

Methods

A resident-intruder paradigm where male Sprague Dawley rats (intruders) were exposed to male Long Evans rats (resident) 1 h daily for a week was used. Bodyweight was measured and blood samples were collected throughout the experiment. Changes in plasma microRNA expression was determined by qPCR.

Results

Rats exposed to social stress showed reduced weight gain compared to controls. Preliminary results suggested that social stress increased the plasma expression of miR-146a-5p, miR-30c- 5p and miR-223-3p.

Conclusions

The data showed that social stress gives reduced weight gain and increased expression of several circulating microRNAs. How this affects the development of persistent pain remains to be investigated.

About the article

Published Online: 2017-07-01

Published in Print: 2017-07-01


Citation Information: Scandinavian Journal of Pain, Volume 16, Issue 1, Pages 169–170, ISSN (Online) 1877-8879, ISSN (Print) 1877-8860, DOI: https://doi.org/10.1016/j.sjpain.2017.04.017.

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