Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Scandinavian Journal of Pain

Official Journal of the Scandinavian Association for the Study of Pain

Editor-in-Chief: Breivik, Harald


CiteScore 2018: 0.85

SCImago Journal Rank (SJR) 2018: 0.494
Source Normalized Impact per Paper (SNIP) 2018: 0.427

Online
ISSN
1877-8879
See all formats and pricing
More options …
Volume 16, Issue 1

Issues

Application of miR-223 onto the dorsal nerve roots in rats induces hypoexcitability in the pain pathways

A. Legfeldt / D.P. Jacobsen
  • National Institute of Occupational Health, Oslo, Norway
  • Department of Bioscience, University of Oslo, Oslo, Norway
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ J. Gjerstad
  • National Institute of Occupational Health, Oslo, Norway
  • Department of Bioscience, University of Oslo, Oslo, Norway
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-07-01 | DOI: https://doi.org/10.1016/j.sjpain.2017.04.037

Abstract

Aims

Lumbar radicular pain is often associated with increased local and systemic synthesis of inflammatory mediators. This process can be modulated by specific microRNAs (miRs). Here, in the animal model, we investigated the effect of miR-223 on the spinal nociceptive signaling and local gene expression.

Methods

In anaesthetized Lewis rats, extracellular single unit recordings of spinal nociceptive activity and qPCR were used to explore the effect of miR-223 application onto the dorsal nerve roots (L3–L5).

Results

A significant decrease in the C-fiber response was observed following application of miR-223 onto the dorsal nerve roots. In addition, the gene expression of interleukin-6 (IL-6) was increased in the spinal cord.

Conclusions

Our data suggest that miR-223 may influence nociceptive signaling in the pain pathways, possibly by modulating the expression of inflammatory mediators.

About the article

Published Online: 2017-07-01

Published in Print: 2017-07-01


Citation Information: Scandinavian Journal of Pain, Volume 16, Issue 1, Pages 177–177, ISSN (Online) 1877-8879, ISSN (Print) 1877-8860, DOI: https://doi.org/10.1016/j.sjpain.2017.04.037.

Export Citation

© 2017 Scandinavian Association for the Study of Pain.Get Permission

Comments (0)

Please log in or register to comment.
Log in