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Scandinavian Journal of Pain

Official Journal of the Scandinavian Association for the Study of Pain

Editor-in-Chief: Breivik, Harald


CiteScore 2018: 0.85

SCImago Journal Rank (SJR) 2018: 0.494
Source Normalized Impact per Paper (SNIP) 2018: 0.427

Online
ISSN
1877-8879
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Volume 16, Issue 1

Issues

Omics as a potential tool to identify biomarkers and to clarify the mechanism of chronic pain development

M.C. Gerra
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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/ C. Dagostino
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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/ S. D’Agnelli
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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/ L. Boggiani
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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/ V. Rizza
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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/ M. Marchesini
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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/ M. Allegri
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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/ G. Fanelli
  • Anesthesia Intensive Care and Pain Unit, Surgical Sciences Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
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Published Online: 2017-07-01 | DOI: https://doi.org/10.1016/j.sjpain.2017.04.064

Abstract

Aims

The present study aims to identify the underlying mechanisms in the acute to chronic pain transition. Acute pain is a physiological response to an experience of noxious stimuli that can progress to chronic, becoming a disease. The negative consequences as personal suffering, reduction in physical function, maladaptive behaviours, reduction of productivity, make this condition a central and common problem affecting individuals and the society. After an acute damage, pain in some cases persists, being the process attributed to different causes, in particular persistent tissue and neuronal damages, central neuroplastic changes, psychosocial factors.

Methods

The techniques actually used to investigate acute and chronic pain offer only a partial explanation of the process and in addition, the obtained results are often far away from the possibility to lead some benefits in the clinical practice. Omics technologies could be the right way to detect biomarkers explaining these mechanisms. Our previous study examined epigenetic and pharmacogenetic aspects of acute and chronic pain in a large group of patients. Other omic approaches, such as metabolomics and glycomics, could help to (1) better identify metabolites that can serve as chronic pain development or side effects therapy biomarkers and to (2) better understand new insights involved into the pathophysiological mechanism that drives from acute to chronic pain. SNPs, DNA methylation, miRNA analyses, expression and protein assays on the identified pathway would than clarify the causative molecular mechanisms. In addition, linking these results to clinical evaluation of the central sensitization processes through algometry in nociceptive and neuropathic pain patients may reveal crucial clinical and pharmacological implications.

Conclusions

Our project will be implemented by omic technologies in different chronic pain patient cohorts (acute low back pain vs chronic low back pain patients and chronic postsurgical pain patients) in order to evaluate new possible pathophysiological mechanism with special focus in central sensitization.

About the article

Published Online: 2017-07-01

Published in Print: 2017-07-01


Citation Information: Scandinavian Journal of Pain, Volume 16, Issue 1, Pages 187–187, ISSN (Online) 1877-8879, ISSN (Print) 1877-8860, DOI: https://doi.org/10.1016/j.sjpain.2017.04.064.

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