Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Scandinavian Journal of Pain

Official Journal of the Scandinavian Association for the Study of Pain

Editor-in-Chief: Werner, Mads

CiteScore 2018: 0.85

SCImago Journal Rank (SJR) 2018: 0.494
Source Normalized Impact per Paper (SNIP) 2018: 0.427

See all formats and pricing
More options …
Volume 16, Issue 1


NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for diclofenac, ibuprofen, naproxen, and celecoxib: what are the alternatives?

Harald Breivik
  • Corresponding author
  • University of Oslo, Faculty of Medicine, Oslo, Norway
  • Oslo University Hospital, Department of Pain Management and Research, Oslo, Norway
  • Oslo University Hospital, Department of Anaesthesiology, Oslo, Norway
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-07-01 | DOI: https://doi.org/10.1016/j.sjpain.2017.05.009


  • [1]

    Mäntyselka P. Balancing act with geriatric pain treatment. Pain 2008;138:1–2.Web of ScienceCrossrefPubMedGoogle Scholar

  • [2]

    Conaghan PG, Peloso PM, Everett SV, Rajagopalan S, Black CM, Mavros P, Arden NK, Phillips CJ, Rannou F, van de Laar MA, Moore RA, Taylor SD. Inadequate pain relief and large functional loss among patients with knee osteoarthritis: evidence from a prospective multinational longitudinal study of osteoarthritis real-world therapies. Rheumatology (Oxford, England) 2015;54:270–7.CrossrefPubMedGoogle Scholar

  • [3]

    Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med 2015;162:46–54.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [4]

    Guyot P, Pandh S, Nixonc RM, Iqbal A, Chaves RL, Moore RA. Efficacy and safety of diclofenac in osteoarthritis: results of a network meta-analysis of unpublished legacy studies. Scand J Pain 2017;16:74–88.Web of ScienceCrossrefPubMedGoogle Scholar

  • [5]

    Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, Brophy JM. Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data. BMJ 2017;357:j1909.Web of SciencePubMedGoogle Scholar

  • [6]

    Carrington Reid M, Eccleston C, Pillemer K. Management of chronic pain in older adults. BMJ 2015;350:h532.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [7]

    Reginster J-Y, Dudler J, Blicharski T, Pavelka K. Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT). Ann Rheum Dis 2017;0:1–7.Web of ScienceGoogle Scholar

  • [8]

    Drewes AM, Munkholm P, Simrén M, Breivik H, Kongsgaard UE, Hatlebakk JG, Agreus L, Friedrichsen M. Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction—recommendations of the Nordic Working Group. Scand J Pain 2016;11:111–22.Web of ScienceGoogle Scholar

  • [9]

    van Walsem A, Pandhi S, Nixon RM, Guyot P, Karabis A, Moore RA. Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis. Arthritis Res Ther 2015;17:66.CrossrefPubMedWeb of ScienceGoogle Scholar

  • [10]

    Breivik H, Tone Marte Ljosaa TM, Stengaard-Pedersen K, Persson J, Aro H, Villumsen J, Tvinnemose D. A 6-months, randomised, placebo-controlled evaluation of efficacy and tolerability of a low-dose 7-day buprenorphine transdermal patch in osteoarthritis patients naïve to potent opioids. Scand J Pain 2010;1:122–41, http://dx.doi.org/10.1016/j.sjpain.2010.05.035.

About the article

Oslo University Hospital, Department of Pain Management and Research, Pbox 4956 Nydalen, 0424 Oslo, Norway.

Published Online: 2017-07-01

Published in Print: 2017-07-01

Conflict of interest: None declared.

Citation Information: Scandinavian Journal of Pain, Volume 16, Issue 1, Pages 148–149, ISSN (Online) 1877-8879, ISSN (Print) 1877-8860, DOI: https://doi.org/10.1016/j.sjpain.2017.05.009.

Export Citation

© 2017 Scandinavian Association for the Study of Pain.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Jay M. Patel, Kamiel S. Saleh, Jason A. Burdick, and Robert L. Mauck
Acta Biomaterialia, 2019, Volume 93, Page 222
Fatemeh Azizi, Fereshteh Ghorat, Mohammad Hassan Rakhshani, and Mostafa Rad
Journal of Herbal Medicine, 2019, Volume 16, Page 100259
Haohan Zhai, Hongni Geng, Bo Bai, and Yulong Wang
Der Orthopäde, 2018

Comments (0)

Please log in or register to comment.
Log in