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Scandinavian Journal of Pain

Official Journal of the Scandinavian Association for the Study of Pain

Editor-in-Chief: Werner, Mads


CiteScore 2018: 0.85

SCImago Journal Rank (SJR) 2018: 0.494
Source Normalized Impact per Paper (SNIP) 2018: 0.427

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1877-8879
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Volume 19, Issue 1

Issues

Patients’ perspective of the effectiveness and acceptability of pharmacological and non-pharmacological treatments of fibromyalgia

Sophie J. Taylor
  • Corresponding author
  • Centre for Behavioural Science and Applied Psychology, Faculty of Social Sciences and Humanities, Sheffield Hallam University, Sheffield, UK
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/ Michael Steer
  • Centre for Behavioural Science and Applied Psychology, Faculty of Social Sciences and Humanities, Sheffield Hallam University, Sheffield, UK
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/ Simon C. Ashe
  • Centre for Behavioural Science and Applied Psychology, Faculty of Social Sciences and Humanities, Sheffield Hallam University, Sheffield, UK
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/ Penny J. Furness
  • Centre for Behavioural Science and Applied Psychology, Faculty of Social Sciences and Humanities, Sheffield Hallam University, Sheffield, UK
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/ Sarah Haywood-Small
  • Biomolecular Sciences Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK
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  • De Gruyter OnlineGoogle Scholar
/ Kim Lawson
  • Biomolecular Sciences Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-10-13 | DOI: https://doi.org/10.1515/sjpain-2018-0116

Abstract

Background and aims

Fibromyalgia is a complex condition characterised by widespread pain, sleep disturbance, fatigue and cognitive impairment, with a global mean prevalence estimated at 2.7%. There are inconsistencies in guidelines on the treatment of fibromyalgia leading to dissatisfaction from patients and healthcare professionals. This study investigated patient-reported outcomes of pharmacological and non-pharmacological treatment usage and effectiveness with an assessment of acceptability.

Methods

Nine hundred and forty-one participants completed a self-administered anonymous questionnaire giving quantitative data of demographics, treatment usage and treatment outcomes. Participant-reported effectiveness and side effects were compared in the following treatment classes: analgesics, antidepressants, gabapentinoids, gastrointestinal treatments, activity interventions, dietary-based treatments, and psychological, physical and alternative therapies. Participants also reported whether they knew about or had tried different treatments.

Results

The results from the online survey indicated that the range of mean effectiveness ratings were similar for pharmacological and non-pharmacological treatments, whereas non-pharmacological treatments had lower side effects ratings and higher acceptability relative to pharmacological treatments. Participants were not aware of some treatment options.

Conclusions

The results show lower side effects ratings and higher acceptability for non-pharmacological treatments compared to pharmacological treatments despite similar effectiveness ratings.

Implications

This article presents results from a large online survey on fibromyalgia patient perspectives of pharmacological and non-pharmacological treatments. Results will inform healthcare professionals and patients about optimal treatments based on ratings of effectiveness, side effects and acceptability that are tailored to patient symptom profiles. Some participants were unaware of treatment options highlighting the importance of patient education allowing collaboration between patients and healthcare professionals to find optimal treatments.

Keywords: fibromyalgia; patients’ perspective; online survey; pharmacological treatments; non-pharmacological treatments

References

  • [1]

    Arnold LM, Crofford LJ, Mease PJ, Burgess SM, Palmer SC, Abetz L, Martin SA. Patient perspectives on the impact of fibromyalgia. Patient Educ Couns 2008;73:114–20.PubMedCrossrefGoogle Scholar

  • [2]

    Shillam CR, Dupree Jones K, Miller L. Fibromyalgia symptoms, physical function, and comorbidity in middle-aged and older adults. Nurs Res 2011;60:309–17.PubMedGoogle Scholar

  • [3]

    Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep 2013;17:356.CrossrefPubMedGoogle Scholar

  • [4]

    Annemans L, Le Lay K, Taïeb C. Societal and patient burden of fibromyalgia syndrome. Pharmacoeconomics 2009;27:547–59.CrossrefPubMedGoogle Scholar

  • [5]

    Arnold LM, Hudson JI, Keck PE, Auchenbach MB, Javaras KN, Hess EV. Comorbidity of fibromyalgia and psychiatric disorders. J Clin Psychiatry 2006;67:1219–25.PubMedCrossrefGoogle Scholar

  • [6]

    Sicras-Mainar A, Rejas J, Navarro R, Blanca M, Morcillo A, Larios R, Velasco S, Villarroya C. Treating patients with fibromyalgia in primary care settings under routine medical practice: a claim database cost and burden of illness study. Arthritis Res Ther 2009;11:R54.CrossrefGoogle Scholar

  • [7]

    Uguz F, Çiçek E, Salli A, Karahan AY, Albayrak İ, Kaya N, Uğurlu A. Axis I and axis II psychiatric disorders in patients with fibromyalgia. Gen Hosp Psychiatry 2010;32:105–7.CrossrefPubMedGoogle Scholar

  • [8]

    Barros de Lorena S, do Carmo Correia de Lima M, Ranzolin A, Duarte AL. Effects of muscle stretching exercises in the treatment of fibromyalgia: a systemic review. Rev Bras Reumatol 2015;55:167–73.Google Scholar

  • [9]

    Choy E, Marshall D, Gabriel ZL, Mitchell SA, Gylee E, Dakin HA. A systematic review and mixed treatment comparison of the efficacy of pharmacological treatments for fibromyalgia. Semin Arthritis Rheum 2011;41:335–45.CrossrefPubMedGoogle Scholar

  • [10]

    Glombiewski JA, Sawyer AT, Gutermann J, Koenig K, Rief W, Hofman SG. Psychological treatments for fibromyalgia: a meta-analysis. Pain 2010;151:280–95.CrossrefPubMedGoogle Scholar

  • [11]

    Terhorst L, Schneider MJ, Kim KH, Goozdich LM, Stilley CS. Complementary and alternative medicine in the treatment of pain in fibromyalgia: a systematic review of randomized control trials. J Manipulative Physiol Ther 2011;34:483–96.CrossrefPubMedGoogle Scholar

  • [12]

    Lawson K. Emerging pharmacological strategies for the treatment of fibromyalgia. World J Pharmacol 2017;6:1–10.CrossrefGoogle Scholar

  • [13]

    Luciano JV, Forero CG, Cerdà-Lafont M, Teresa Peñarrubia-María M, Fernández-Vergel R, Cuesta-Vargas AI, Ruíz JM, Rozadilla-Sacanell A, Sirvent-Alierta E, Santo-Panero P, García-Campayo J, Serrano-Blanco A, Pérez-Aranda A, Rubio-Valera M. Functional status, quality of life, and costs associated with fibromyalgia subgroups: a latent profile analysis. Clin J Pain 2016;32:829–40.CrossrefPubMedGoogle Scholar

  • [14]

    Wilson HD, Robinson JP, Turk DC. Toward the identification of symptom patterns in people with fibromyalgia. Arthritis Care Res 2009;61:527–34.CrossrefGoogle Scholar

  • [15]

    Häuser W, Walitt B, Fitzcharles M-A, Sommer C. Review of pharmacological therapies in fibromyalgia syndrome. Arthritis Res Ther 2014;16:201.PubMedCrossrefGoogle Scholar

  • [16]

    Lawson K. Potential drug therapies for the treatment of fibromyalgia. Expert Opin Investig Drugs 2016;25:1071–81.CrossrefPubMedGoogle Scholar

  • [17]

    Häuser W, Thieme K, Turk DC. Guidelines on the management of fibromyalgia syndrome – a systematic review. Eur J Pain 2010;14:5–10.CrossrefPubMedGoogle Scholar

  • [18]

    Kia S, Choy E. Update on treatment guideline in fibromyalgia syndrome with focus on pharmacology. Biomedicines 2017;5:20.CrossrefGoogle Scholar

  • [19]

    Thieme K, Mathys M, Turk DC. Evidence-based guidelines on the treatment of fibromyalgia patients: are they consistent and if not, why not? Have effective psychological treatments been overlooked? J Pain 2017;18:747–56.PubMedCrossrefGoogle Scholar

  • [20]

    Carville SF, Arendt-Nielsen S, Bliddal H, Blotman F, Branco JC, Buskila D, Da Silva JA, Danneskiold-Samsøe B, Dincer F, Henriksson C, Henriksson KG, Kosek E, Longley K, McCarthy GM, Perrot S, Puszczewicz M, Sarzi-Puttini P, Silman A, Spãth M, Choy EH, et al. EULAR evidence based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 2008;67:536–41.PubMedGoogle Scholar

  • [21]

    Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluβ E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis 2017;76:318–28.PubMedCrossrefGoogle Scholar

  • [22]

    Arnold LM, Gebke KB, Choy EH. Fibromyalgia: management strategies for primary care providers. Int J Clin Pract 2016;70:99–112.PubMedCrossrefGoogle Scholar

  • [23]

    Häuser W, Arnold B, Eich W, Felde E, Flügge C, Henningsen P, Herrmann M, Köllner V, Kühn E, Nutzinger D, Offenbächer M, Schiltenwolf M, Sommer C, Thieme K, Kopp I. Management of fibromyalgia syndrome – an interdisciplinary evidence-based guidelines. Ger Med Sci 2008;6:14.Google Scholar

  • [24]

    Fitzcharles MA, Ste-Marie PA, Goldenberg DL, Pereira JX, Abbey S, Choinière M, Ko G, Moulin DE, Panopalis P, Proulx J, Shir Y, National Fibromyalgia Guideline Advisory Panel. 2012 Canadian guidelines for the diagnosis and management of fibromyalgia syndrome: executive summary. Pain Res Manag 2013;18:119–26.Google Scholar

  • [25]

    Ablin JN, Amital H, Ehrenfeld M, Aloush V, Elkayam O, Langevitz P, Mevorach D, Mader R, Sachar T, Amital D, Buskila D, Israeli Rheumatology Association. Guidelines for the diagnosis and treatment of the fibromyalgia syndrome. Harefuah 2013;152:742–7.PubMedGoogle Scholar

  • [26]

    Schiltenwolf M, Eidmann U, Koellner V, Kühn T, Offenbächer M, Petzke F, Sarholz M, Weigl M, Wolf B, Häuser W. Multimodal therapy of fibromyalgia syndrome. Der Schmerz 2017;31: 285–8.Google Scholar

  • [27]

    Briones-Vozmediano E, Vives-Cases C, Ronda-Pérez E, Gil-González D. Patients’ and professionals’ views on managing fibromyalgia. Pain Res Manag 2013;18:19–24.CrossrefPubMedGoogle Scholar

  • [28]

    Ashe S, Furness P, Taylor S, Haywood-Small S, Lawson K. A qualitative exploration of the experiences of living with and being treated for fibromyalgia. Health Psychol Open 2017;4: 1–12.Google Scholar

  • [29]

    Perrot S, Russell IJ. More ubiquitous effects from non-pharmacologic than from pharmacologic treatments for fibromyalgia syndrome: a meta-analysis examining six core symptoms. Eur J Pain 2014;18:1067–80.PubMedCrossrefGoogle Scholar

  • [30]

    Mease PJ, Clauw DJ, Christensen R, Crofford L, Gendreau M, Maartin SA, Simon L, Strand V, Williams DA, Arnold LM. Toward development of a fibromyalgia responder index and disease activity score: OMERACT module update. J Rheumatol 2014;38:1487–95.Google Scholar

  • [31]

    Bennett RM, Jones J, Turk DC, Russell IJ, Matallana L. An internet survey of 2,596 people with fibromyalgia. BMC Musculoskelet Disord 2007;8:27.CrossrefPubMedGoogle Scholar

  • [32]

    Häuser W, Jung E, Erbslöh-Möller B, Gesmann M, Kühn-Becker H, Petermann F, Langhorst J, Thoma R, Weiss T, Wolfe F, Winkelmann A. The German fibromyalgia consumer reports – a cross-sectional survey. BMC Musculoskeletal Disorders 2012;13:74.PubMedCrossrefGoogle Scholar

  • [33]

    Qualtrics. Qualtrics software. Version December 2015. Provo, UT: Qualtrics, 2015. Available at: http://www.qualtrics.com.

  • [34]

    López-Pousa S, Garre-Olmo J, de Gracia M, Ribot J, Calvó-Perxas L, Vilalta-Franch J. Development of a multidimensional measure of fibromyalgia symptomatology: the comprehensive rating scale for fibromyalgia symptomatology. J Psychosom Res 2013;74:384–92.CrossrefPubMedGoogle Scholar

  • [35]

    Snaith RP, Zigmond AS. HADS: hospital anxiety and depression scale. Windsor: NFER Nelson, 1994.Google Scholar

  • [36]

    Field A. Discovering statistics using IBM SPSS statistics, 4th ed. London: Sage, 2013.Google Scholar

  • [37]

    Torres X, Bailles E, Valdes M, Gutierrez F, Peri J-M, Arias A, Gomez E, Collado A. Personality does not distinguish people with fibromyalgia but identifies subgroups of patients. Gen Hosp Psychiatry 2013;35:640–8.PubMedCrossrefGoogle Scholar

  • [38]

    Busch AJ, Webber SC, Richards RS, Bidone J, Schachter CL, Schafer LA, Danyliw A, Sawant A, Dal Bello-Haas V, Rader T, Overand TJ. Resistance exercise training for fibromyalgia. Cochrane Database Syst Rev 2013:CD010884.PubMedGoogle Scholar

  • [39]

    Schachter CL, Busch AJ, Peloso PM, Sheppard MS. Effects of short versus long bouts of aerobic exercise in sedentary women with fibromyalgia: a randomized controlled trial. Phys Ther 2003;83:340–58.PubMedGoogle Scholar

  • [40]

    Dönmez A, Karagülle MZ, Tercan N, Dinler M, İşsever H, Karagülle M, Turan M. SPA therapy in fibromyalgia: a randomised controlled clinic study. Rheumatol Int 2005;26: 168–72.CrossrefPubMedGoogle Scholar

  • [41]

    Jack K, McLean SM, Moffett JK, Gardiner E. Barriers to treatment adherence in physiotherapy outpatient clinics: a systematic review. Man Ther 2010;15:220–8.PubMedCrossrefGoogle Scholar

  • [42]

    Moffett J, McLean S. The role of the physiotherapist in the management of non-specific back pain and neck pain. Rheumatology 2006;45:371–8.CrossrefPubMedGoogle Scholar

  • [43]

    García DA, Nicolás IM, Hernández PJS. Clinical approach to fibromyalgia: synthesis of evidence-based recommendations: a systematic review. Rheumatol Clin 2016;12:65–71.Google Scholar

  • [44]

    Isasi C, Colmenero I, Casco F, Tejerina E, Fernandez N, Serrano-Vela JI, Castro MJ, Villa LF. Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia. Rheumatol Int 2014;34:1607–12.PubMedCrossrefGoogle Scholar

  • [45]

    De Giorgio R, Volta U, Gibson PR. Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction. Gut 2016;65:169–78.CrossrefPubMedGoogle Scholar

  • [46]

    Marum AP, Moreira C, Saraiva F, Tomas-Carus P, Sousa-Guerreiro C. A low fermentable oligo-di-mono saccharides and polyls (FODMAP) diet reduced pain and improved daily life in fibromyalgia patients. Scand J Pain 2016;13:166–72.PubMedCrossrefGoogle Scholar

  • [47]

    Rossi A, Di Lollo AC, Guzzo MP, Giacomelli C, Atzeni F, Bazzichi L, Di Franco M. Fibromyalgia and nutrition: what news? Clin Exp Rheumatol 2015;33:S117–25.PubMedGoogle Scholar

  • [48]

    Lauche R, Cramer H, Dobos G, Langhorst J, Schmidt S. A systematic review and meta-analysis of mindfulness-based stress reduction for the fibromyalgia syndrome. J Psychosom Res 2013;75:500–10.PubMedCrossrefGoogle Scholar

  • [49]

    Singh LP, Kapoor M, Singh SB. Heat: not black, not white. It’s gray!!! J Basic Clin Physiol Pharmacol 2013;24:209–24.PubMedGoogle Scholar

  • [50]

    Romeyke T, Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia-Effects on pain intensity and mental state: a non-randomised controlled study. J Musculoskeletal Res 2014;22:341–55.CrossrefGoogle Scholar

  • [51]

    Matsumoto S, Shimodozono M, Etoh S, Miyata R, Kawahira K. Effects of thermal therapy combining sauna therapy and underwater exercise in patients with fibromyalgia. Complement Ther Clin Pract 2011;17:162–6.CrossrefPubMedGoogle Scholar

  • [52]

    Fischer E, Solomon S. Physiological responses to heat and cold. In: Licht S, editor. Therapeutic Heat and Cold. 2nd ed. Baltimore: Waverley Press, 1965:126–69.Google Scholar

  • [53]

    Glaser EM, Shephard RJ. Simultaneous experimental acclimatization to heat and cold in man. J Physiol 1963;169: 592–602.PubMedCrossrefGoogle Scholar

  • [54]

    Subnis UB, Starkweather A, Menzies V. A current review of distraction-based interventions for chronic pain management. Eur J Integr Med 2016;8:715–22.CrossrefGoogle Scholar

  • [55]

    Wright KB. Researching internet-based populations: advantages and disadvantages of online survey research, online questionnaire authoring software packages, and web survey services. J Comput Mediat Commun 2005;10:JCMC 1034.Google Scholar

  • [56]

    Office for National Statistics. Graduates in the UK labour market 2017. Available at: https://www.ons.gov.uk/employmentandlabourmarket/peopleinwork/employmentandemployeetypes/articles/graduatesintheuklabourmarket/2017#steady-increase-in-the-number-of-graduates-in-the-uk-over-the-past-decade. Accessed: 15 Aug 2018.

About the article

Corresponding author: Dr. Sophie J. Taylor, Centre for Behavioural Science and Applied Psychology, Faculty of Social Sciences and Humanities, Sheffield Hallam University, Heart of the Campus, Collegiate Crescent, Sheffield S10 2BP, UK


Received: 2018-07-19

Revised: 2018-09-10

Accepted: 2018-09-19

Published Online: 2018-10-13

Published in Print: 2019-01-28


Authors’ statements

Research funding: SA received financial support from Folly Pogs Fibromyalgia Research UK. SA and MS received financial support from the Department of Psychology, Sociology & Politics, Sheffield Hallam University.

Conflict of interest: Authors have no conflicts of interest to declare.

Informed consent: Participants were informed of the nature of the survey and what information would be collected so they could decide whether to take part. Completion and submission of the survey was taken as implied consent.

Ethical approval: This project received ethical approval from the Sheffield Hallam University Research Ethics Committee.


Citation Information: Scandinavian Journal of Pain, Volume 19, Issue 1, Pages 167–181, ISSN (Online) 1877-8879, ISSN (Print) 1877-8860, DOI: https://doi.org/10.1515/sjpain-2018-0116.

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